Protective effect of JBP485 on concanavalin A-induced liver injury in mice

Abstract

These results indicated that immune-mediated liver damage can be prevented by JBP485, and that this is mainly associated with immunomodulatory effects on T cells and adhesion molecules, antioxidation, and inhibition of apoptosis.

Preventive and therapeutic potential of placental extract in contact hypersensitivity

“…While immune-regulatory functions of placental extract are likely dependent on additive and synergistic effects of these components, one of potential candidates is cyclo-trans-4-L-hydroxyprolyl-L-serine, a dipeptide isolated from hydrolysates of placental extract [31, 32]. It has been reported that administration of cyclo-trans-4-L-hydroxyprolyl-L-serine ameliorates inflammation in the liver [33]. Thus, we next examined a potential effect of cyclo-trans-4-L-hydroxyprolyl-L-serine in CHS.…”

“…The process of placenta acquisition and extract preparation was concordant with those for Laennec, a drug of placental extracts for liver dysfunction that has been approved by Ministry of Health, Labour and Welfare in Japan. Cyclo-trans-4-L-hydroxyprolyl-L-serine (also called as JBP485), which is isolated from hydrolysates of placental extract, was prepared as previously reported [31-33]. …”

Human placental extract treatment for non‐alcoholic steatohepatitis non‐responsive to lifestyle intervention: A pilot study

“…HPE is enriched in enzymes, nucleic acid, vitamins, amino acids, steroids, fatty acids and minerals . HPE mediates immunotrophic, antioxidative and anti‐inflammatory responses . HPE has recently been used to treat various diseases (chronic liver diseases [CLD], menopausal syndrome, chronic fatigue syndrome, atopic dermatitis, aging and so on).…”

“…3 HPE mediates immunotrophic, antioxidative and anti-inflammatory responses. [4][5][6][7] HPE has recently been used to treat various diseases (chronic liver diseases [CLD], [8][9][10][11] menopausal syndrome, 12 chronic fatigue syndrome, 13 atopic dermatitis, aging 14 and so on). Laennec, a trade name for the hydrolysate of human placenta, has been enantioselectively synthesized by chemical means.…”

JBP485 promotes tear and mucin secretion in ocular surface epithelia

“…JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide that was first isolated from placental extract (PE) as a mitogen for a kidney cell line, and it has subsequently been synthesized by chemical means 16 17 . Previous studies have demonstrated that JBP485 has anti-inflammatory and anti-apoptotic effects and that it exhibits protective properties for liver and gastrointestinal cells 17 18 19 20 21 . Recently, we discovered that JBP485 promotes the cell proliferation of corneal epithelium during wound healing (unpublished data).…”