Protective Effect of Kolaviron, a Biflavonoid from Garcinia kola Seeds, in Brain of Wistar Albino Rats Exposed to Gamma-Radiation

Adaramoye, Oluwatosin A.

doi:10.1248/bpb.33.260

Cited by 46 publications

(26 citation statements)

References 35 publications

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“…1 Also kolaviron has been shown to protect neurons against gamma radiation induced oxidative stress. 20 The present study indicates that kolaviron at various doses, does not cause neurodegenerative changes in the hippocampus and striatum.…”

Section: Discussionsupporting

confidence: 56%

Kolaviron, isolated from Garcinia kola, inhibits Acetylcholinesterase activities in the Hippocampus and Striatum of Wistar rats

Ijomone¹,

Augustine²

2013

ANS

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BackgroundKolaviron, isolated from seeds of Garcinia kola, have been shown to possess wide pharmacological properties.PurposeThe present study examined the effect of kolaviron on acetylcholinesterase activities in the hippocampus and striatum of adult Wistar rats.MethodsIn this study, histological and histochemical methods were used to investigate the effects of kolaviron on the histology of the hippocampus and striatum and on acetylcholinesterase activities in these brain regions.ResultsWe showed that kolaviron produced no neurodegenerative changes in the hippocampus and striatum. Kolaviron did not significantly alter (p<0.05) neuronal density in these brain regions. Kolaviron significantly reduced (p<0.05) acetylcholinesterase staining intensity, suggesting a likely inhibiting effect on this enzyme.ConclusionTo the best of our knowledge, this study provides the first evidence that kolaviron could act as an acetylcholinesterase inhibitor. Kolaviron may be developed as a herbal-based natural product with therapeutic potential in the management of neurodegenerative disorders associated with disturbed cholinergic neurotransmitter systems.

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Section: Discussionsupporting

confidence: 56%

Kolaviron, isolated from Garcinia kola, inhibits Acetylcholinesterase activities in the Hippocampus and Striatum of Wistar rats

Ijomone¹,

Augustine²

2013

ANS

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“…Due to the antioxidant properties of kolaviron, it has the potential to protect the neurons of the brain from toxic damage. A recent study has shown kolaviron to protect the neurons against gamma radiation induced oxidative stress in brain of exposed rats [13].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

Ijomone¹,

Nwoha²,

Olaibi³

et al. 2012

Macedonian Journal of Medical Sciences

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Aim: To investigate the protective effects of kolaviron on brain weight and behavioural performance and the histology of the hippocampus of adult Wistar rats following methamphetamine challenge. Materials and Methods:Twenty four adult Wistar rats weighing between 150-200 g, randomly assigned into four groups of six each (Groups A, B, C, D) were used for this research. Group A served as control, while groups B and C were given single dose methamphetamine (10 mg/kg) intraperitoneally after group C was pre-treated with kolaviron (200 mg/kg) for 7 days and group D received cornoil (vehicle for kolaviron) only.Results: High level of methamphetamine-induced stereotypic movement was observed, and the onset was delayed by kolaviron administration. Animals administered methamphetamine only, showed significantly poor behavioural performance on the water maze after treatment when compared to the other groups (P<0.05). Histological analysis revealed neuronal destruction of the pyramidal layer of the hippocampus following methamphetamine administration. Kolaviron to some extent prevented destruction of pyramidal cells of the hippocampus in pre-treated rats. Conclusion:The present findings show the neuro-destructive effects of methamphetamine on hippocampal neurons and its ability to negatively affect behaviour and that kolaviron could prevent such behavioural deficit and also afford some protection to the hippocampus.

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“…of the whole-body irradiated rats, indicating the presence of radiation-induced oxidative damage. Moreover, the study of Adaramoye (2010) showed an increase of serum levels of MDA, urea and activities of ALT, AST and decrease of GSH level and activities of GST, CAT and SOD in rats exposed to 5 Gy γ-radiation. The observed increased level of MDA may be due to the attack of free radicals on the fatty acid component of membrane lipids (Kamat et al, 2000), leading to lipid peroxidation.…”

Section: Discussionmentioning

confidence: 96%

The protective effect of Catechin and Rutin on cigarette smoke extract-induced injury in irradiated rats

et al. 2017

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T HE present study was designed to investigate the possible protective effects of catechin and rutin and their possible mechanisms of action in guarding against the oxidative stress and inflammation induced by ionizing radiation and/ or cigarette smoke extract in rats. Exposure of rats to acute doses of γ-radiation or administration of cigarette smoke extract (CSE) in this study were found to exert an oxidative stress due to generation of ROS, which are characterized by elevation in MDA and nitric oxide levels and depletion in reduced glutathione, as well as elevation in MPO activity and level of TNF-α. The results also showed that activities of ALT, AST, ALP, and LDH were increased. Damaging effects were significantly increased in animals exposed to gamma radiation combined with administration of cigarette smoke extract in comparison to either irradiation or administration of cigarette smoke extract. Pretreatment with catechin or rutin largely protected against the change in all the measured parameters. Conclusion: Catechin and rutin might have the potential to modulate the damage induced by radiation exposure in cigarette smoke-treated animals

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Protective Effect of Kolaviron, a Biflavonoid from Garcinia kola Seeds, in Brain of Wistar Albino Rats Exposed to Gamma-Radiation

Cited by 46 publications

References 35 publications

Kolaviron, isolated from Garcinia kola, inhibits Acetylcholinesterase activities in the Hippocampus and Striatum of Wistar rats

Kolaviron, isolated from Garcinia kola, inhibits Acetylcholinesterase activities in the Hippocampus and Striatum of Wistar rats

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

The protective effect of Catechin and Rutin on cigarette smoke extract-induced injury in irradiated rats

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