Protective effect of L-carnitine in a rat model of retinopathy of prematurity

Yıldız, Kader; Kul, Oğuz; Gökpınar, Sami; Atmaca, Hasan; Gençay, Yılmaz Emre; Gazyağci, Aycan Nuriye; Babür, Cahit; Gürcan, İsmayil Safa

doi:10.3906/sag-1301-9

Cited by 8 publications

(5 citation statements)

References 68 publications

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“…In an experimental animal study that investigated the effects of L-carnitine on oxygen-induced retinopathy, the authors found that L-carnitine supplementation offered protection against retinopathy development, a finding that is in line with our findings [18]. Although ROP was observed to be approximately two times higher in the group that did not receive carnitine, this difference was not significant in our study.…”

Section: Discussionsupporting

confidence: 91%

The protective effect of L-carnitine supplementation on retinopathy of prematurity: A retrospective cohort study

SİLAHLI¹,

TEKİN²,

BİLGİN³

et al. 2022

Journal of Surgery and Medicine

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Background/Aim: Retinopathy of prematurity (ROP) is important morbidity in premature infants and is the most common preventable cause of blindness in childhood. Carnitine is a key molecule in energy metabolism and in oxidation of fatty acids, which are the main structural component of phospholipid membrane of the brain and retinal cells. Premature babies are born with insufficient carnitine pools. This study aimed to evaluate the effect of carnitine replacement on ROP in premature infants aged < 34 gestational weeks. Methods: Premature infant records between 2014 and 2019 were retrospectively examined. All premature infants at gestational ages < 34 weeks were included. Data from the two groups who received/did not receive carnitine supplementation in total parenteral nutrition (TPN) over two consecutive time periods and whose ROP examination was complete were recorded retrospectively. Fifty-eight out of 125 infants were in the carnitine group, and 67 formed the non-carnitine group (CG and NCG, respectively). The morbidity data from subjects, especially those with ROP, who received (CG) and did not receive carnitine (NCG), were compared. Results: Of the 125 infants enrolled, no significant differences in gestational age (P = 0.323) or birth weight (P = 0.597) between the groups was found. The Cox regression analysis revealed that carnitine replacement in the premature infant was a protective factor for ROP (P = 0.045, B = −0.933, hazard ratio 0.393, 95% confidence interval 0.158-0.978). Conclusion: Carnitine supplementation may offer protection from developing ROP during exposure to oxygen in premature infants.

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Section: Discussionsupporting

confidence: 91%

The protective effect of L-carnitine supplementation on retinopathy of prematurity: A retrospective cohort study

SİLAHLI¹,

TEKİN²,

BİLGİN³

et al. 2022

Journal of Surgery and Medicine

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“…Furthermore, Yousry et al [ 22 ] noted an improvement in chronic heart failure treated with sage oil as a curative rather than prophylactic measure. ROS are generated in the heart by normal mitochondrial functions as well as by enzymatic reactions [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Sage (Salvia officinalis) alleviates trazadone induced rat cardiotoxicity mediated via modulation of autophagy and oxidative stress

Al-Gholam,

Hathout,

Safwat

et al. 2024

Anat Cell Biol

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The antidepressant drug trazodone (TRZ) is commonly used for treating depression, anxiety, and insomnia, however, it causes cardiotoxicity, which is one of its limitations. The objective of this work was to investigate the impact of sage (Salvia officinalis) in rats against cardiotoxicity induced by TRZ and to investigate the mechanisms involved in its cardio-protective properties through autophagy and oxidative stress. Fifty male albino rats were split randomly into five experimental groups: control group, sage oil group (100 mg/kg), TRZ group (20 mg/kg), protective group, and curative group. Cardiac function biomarkers (aspartate aminotransferase [AST], creatine kinase-MB [CK-MB], and cardiac troponin T [cTnI]) were assessed in serum. Oxidative stress and inflammatory biomarkers in cardiac tissue (total antioxidant capacity, malondialdehyde, and tumor necrosis factor-α) were evaluated. Heart tissues were subjected to histological, immunohistochemical, and ultrastructural evaluations. DNA damage also evaluated. Significant rise in the levels of AST, CK-MB, and cTnI were observed with enhanced autophagy along with marked histopathological changes in the form of interrupted muscle fibers with wide interstitial spaces with areas of hemorrhage and extravasated blood and interstitial mononuclear cellular infiltration in TRZ group. DNA damage was also significantly increased in TRZ group. However, administration of sage in both protective and curative groups show marked improvement of the cardiac alterations. In conclusion, sage ameliorated the alterations in the heart induced by trazadone through modulation of autophagy and oxidative stress.

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“…In the heart, reactive oxygen species are produced during normal cellular functions of mitochondria during oxidative phosphorylation as well as enzymatic reactions catalyzed by xanthine oxidase, NAD(P)H oxidases, and cytochrome P450 [ 35 ]. As the oxidative status of the cardiac tissue was assessed following TRZ treatment, a diminished catalase activity and increased MDA levels were reported, as well as a decrease in total thiol levels, when compared to the control, LC, and LC + TRZ groups.…”

Section: Discussionmentioning

confidence: 99%

l-Carnitine Mitigates Trazadone Induced Rat Cardiotoxicity Mediated via Modulation of Autophagy and Oxidative Stress

2022

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Trazodone (TRZ) is an antidepressant drug which widely used to treat insomnia, but it has a cardiotoxic effect which considered one of the TRZ limitations. The aim of this study was to investigate the protective role of l-carnitine in rats against TRZ-induced cardiotoxicity, as well as to look into the molecular mechanisms underlying its cardioprotective effects via autophagy-mediated cell death and oxidative stress. Male albino rats were randomized into four experimental groups (n = 8): normal control, TRZ group (TRZ, 20 mg/kg/day), l-carnitine group (LC, 200 mg/kg/day), and Co-treated group (l-carnitine and TRZ). All treatments were administered via oral gavage for 4 weeks. Cardiac enzymes (AST & CK-MB) and serum cardiac troponin T(cTnI) were assessed. Oxidative stress biomarkers in heart tissue (malondialdehyde; MDA, total thiol, and catalase activity) were measured. Autophagy related-genes (ATG-5 and Beclin-1), P62, and TNF-α were quantified. AST and CK-MB and cTnI significantly (p < 0.001) were increased with enhanced autophagy as well as severe histopathological changes which were manifested as scattered chronic inflammatory cells with focal fragmentation of myocardial fibers and loss of nuclei in TRZ-treated group. However, daily administration of l-carnitine (200 mg/kg) for 28 days completely reversed TRZ-induced the increased cardiac enzymes, autophagy, and myocardial inflammatory processes to the normal values. TRZ administration might have the potential to cause cardiotoxic effects that can be treated with l-carnitine administration.

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Protective effect of L-carnitine in a rat model of retinopathy of prematurity

Cited by 8 publications

References 68 publications

The protective effect of L-carnitine supplementation on retinopathy of prematurity: A retrospective cohort study

The protective effect of L-carnitine supplementation on retinopathy of prematurity: A retrospective cohort study

Sage (Salvia officinalis) alleviates trazadone induced rat cardiotoxicity mediated via modulation of autophagy and oxidative stress

l-Carnitine Mitigates Trazadone Induced Rat Cardiotoxicity Mediated via Modulation of Autophagy and Oxidative Stress

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