Protective effect of Liankoushengji Powder on rats with Traumatized

Abstract

Purpose: Study on the effect of modified liankou Shengji powder on treating skin injury rats. Materials and Methods: Divided sixteen male SD rats were randomly into four groups: model group, normal group, modified liankoushengji powder group and Yunnan Baiyao powder group. The other three groups except the normal group were modeled as follows to form a mechanical damage animal model: the left three sides of the back were surgically cut into square full-thickness skin defects, deep into the skin, with a length of about 1 cm on the side. After the mold-building was successful, modified liankoushengji powder and Yunnan Baiyao powder were mixed with the appropriate amount of Vaseline into a paste and then applied to the affected area of rats for drug intervention. All rats in the model group were coated with Vaseline twice a day for 4 days. To observe the body temperature and the growth wounds by glare projection of all rats. Then to calculate the wound healing rate. And to detect Vascular Endothelial Growth Factor (VEGF) by ELISA. Results: In modified liankoushengji powder group, the body temperature was no observable change comparing with the normal group (p> 0.05). But the changes of the increased new capillary formation and the enhanced wound healing rate were significant differences comparing with the normal group(p<0.01).The enhanced concentration of VEGF was statistically significant (p<0.05).With little change in body temperature, there was no remarkable difference between the modified liankoushengji powder group and the Yunnan Baiyao powder group(p> 0.05). The changes of the increased new capillary formation and the enhanced wound healing rate were significant differences in the modified liankoushengji powder group comparing with the Yunnan Baiyao powder group(p <0.05).The enhanced