Protective Effect of Litchi chinensis Peel Extract-Prepared Nanoparticles on Rabbits Experimentally Infected with Eimeria stiedae

Abstract

The present study used Litchi chinensis peel extract to synthesize silver nanoparticles (AgNPs). This technique is eco-friendly and can be performed in a single step; thus, it has attracted great attention for NP biosynthesis. Herein, we biosynthesized AgNPs with L. chinensis peel extract and examined their anticoccidial activity in rabbit hepatic coccidiosis induced by E. stiedae infection. Thirty-five rabbits were allocated into seven groups: a healthy group (G1), an infected control group (G2), four groups infected before treatment with 10 mg/kg L. chinensis peel extract-biosynthesized AgNPs (G3, G5) or 50 mg/kg amprolium (G4, G6), and rabbits infected after two weeks of pretreatment with 10 mg/kg L. chinensis eel extract-biosynthesized AgNPs (G7). In this study, both pre-and post-treatment with AgNPs produced a substantial reduction in fecal oocyst output, liver enzyme levels, and histopathological hepatic lesions relative to the infected group. In conclusion, L. chinensis peel extract-prepared AgNPs should be considered harmless and efficient in the cure of hepatic coccidiosis in rabbits.

The Efficacy of Alcoholic Extracts of Morus Macroura (Mulberries), Lepidium Sativum (Garden Cress Seeds) and Diclazuril Against E. stiedae in Experimentally Infected Rabbits

“…PM lesion and histopathological changes of the liver of sacrificed rabbit in G4 (CP) were consistent with the previous research (Al-Naimi et al 2012;Kardena et al 2015;Harcourt-Brown et al 2020;Metwally et al 2022). These lesions may be caused by the released toxins by Eimeria stiedae or mechanical irritation or due to lipid peroxidation produced by E. stiedae, resulting in the destruction of the bile ducts and consequently hepatic parenchyma.…”