Protective Effect of <i>Bombyx mori</i> L Cocoon (Abresham) and its Formulations against Isoproterenol-Induced Cardiac Damage

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

“…ISO is a synthetic non-selective b adrenoceptor agonist and in arrears to its positive inotropic and chronotropic effects has been reported to produce ischaemia-like condition as a result of disturbed physiological balance between production of free radicals and antioxidative defence system [14,15]. It is the heightened condition of myocardial damage which causes cardiac dysfunction, increased malondialdehyde content, altered activities of cardiac injury marker or the membrane-bound protectors of heart and antioxidant enzymes and increases cell level of myocardial necrosis that have been caught up as important risk factors in the defeat of integrity and functions of myocardial membranes [16][17][18][19][20][21][22]. The pathophysiological and morphological alterations pragmatic in ISO-treated rats have been found to be analogous to those observed in human myocardial infarction [23].…”

“Perspective of Ischemic Heart Disease (Iqfari Marad-i-Qalb) with reference to Unani Medicine”

“…Various preclinical and clinical studies have been conducted to explore the cardioprotective properties of some of these drugs. Abresham (Bombyx mori) and its formulations (Khamira Abresham Hakeem Arshadwala and Khamira Abresham sada) have antioxidant and free radical scavenging effects 16,17 . Additionally, the amino acids histidine, tryptophan, and cysteine as well as the active ingredient sericin improve dyslipidaemia.…”

Bombyx mori cocoon as a promising pharmacological agent: A review of ethnopharmacology, chemistry, and biological activities

“…Cardioprotective activities: Some studies have looked at the efficacy of silk cocoons on the cardiovascular system. In a preclinical study by Mahmood T et al [25] on in vivo model, the effect of pretreatment by different formulations of cocoon silk extract, especially Khamira Abresham Sada and Khamira Abresham Hakim Arshad Wala, was studied against Wistar rats induced cardiotoxicity by isoproterenol consumption. The results exhibited the silk formulations were able to suppress heart damage through decreased cardiac marker enzymes (such as CK-MB and troponin), heart weight to body weight ratio, and degree of myonecrosis and filtration of inflammatory cells, as well as improved heart recovery, cardiac antioxidant capacity, and lipid peroxidation.…”