Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity

Ha, Ki‐Tae; Yoon, Sang-Ju; Choi, Dall-Yeong; Kim, Dong-Wook; Kim, June-Ki; Kim, Cheorl-Ho

doi:10.1016/j.jep.2004.09.054

Cited by 91 publications

(60 citation statements)

References 30 publications

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“…Hepatotoxicants, including viruses, fungal products, bacterial metabolites, minerals, environmental pollutants and chemotherapeutic agents, can induce various disorders of the organ (Ha et al, 2005). Numerous herbal plants and their formulations are, therefore, used widely for the recovery of liver from various diseases.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Eidi

Moghadam

Mortazavi

et al. 2013

Pharmaceutical Biology

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Context: Different parts of the walnut [Juglans regia L. (Juglandaceae)] have been used in folk medicine for protection against liver injury, although its actual efficacy remains uncertain. Objective: The present study investigated the protective effect of walnut leaf extract against carbon tetrachloride (CCl 4 )-induced liver damage in rats. Materials and methods: The rats were randomly divided into seven groups: control, CCl 4 (i.p., 0.5 mL/kg b.w., 50% CCl 4 in olive oil), walnut extract (at dose level of 0.2 g/kg b.w.) alone, walnut extract (at dose levels of 0.05, 0.1, 0.2 and 0.4 g/kg b.w.) with CCl 4 , and treatment was carried out accordingly. On the 28th day, rats were sacrificed and blood was withdrawn by cardiac puncture. Liver damage was assessed by serum biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin), antioxidant enzymes (superoxide dismutase and catalase) and histopathological observation. Results: Administration of walnut leaf extract (ranging from 0.2 to 0.4 g/kg b.w.) significantly lowered serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels in CCl 4 -treated rats. Walnut leaf extract increased antioxidant enzymes, including superoxide dismutase and catalase. Histopathological examination of livers showed that walnut leaves extract reduced fatty degeneration, cytoplasmic vacuolization and necrosis in CCl 4 -treated rats. Discussion and conclusion: These results suggest that walnut extract has a protective effect over CCl 4 -induced oxidative damage in rat liver. These results demonstrate that walnut extract acts as a good hepatoprotective and antioxidant agent in attenuating hepatocellular damage.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Eidi

Moghadam

Mortazavi

et al. 2013

Pharmaceutical Biology

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“…DOI: 10.3109/13880209.2014.967782 It is well known that CCl 4 is biotransformed by the Cyt P450 system to produce a trichloromethyl-free radical, which further undergoes reduction to form a trichloromethylperoxyl radical, which leads to LPO and finally leads to cell death (Clawson, 1989;Recknagel et al, 1989). Therefore, leakage of large quantities of enzymes into the blood stream is often associated with massive necrosis of the liver (Ha et al, 2005;Rees & Spector, 1961). Our study corroborates previous findings and elicited a significant increase in the activities of serum enzymes (AST, ALT, and ALP in serum); hepatic LPO levels and decreased levels of antioxidant marker (GSH) on exposure of rats to CCl 4 , indicating considerable hepatocellular injury (Ha et al, 2005;Rawat et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, leakage of large quantities of enzymes into the blood stream is often associated with massive necrosis of the liver (Ha et al, 2005;Rees & Spector, 1961). Our study corroborates previous findings and elicited a significant increase in the activities of serum enzymes (AST, ALT, and ALP in serum); hepatic LPO levels and decreased levels of antioxidant marker (GSH) on exposure of rats to CCl 4 , indicating considerable hepatocellular injury (Ha et al, 2005;Rawat et al, 1997). GSH is an important endogenous antioxidant system, known to have key functions in protective mechanism.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats

Ganaie

Khan

Siddiqui

et al. 2015

Pharmaceutical Biology

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Context: Rumex vesicarius L. (Polygonaceae), an edible plant, is reported to have many bioactive phytochemicals, especially flavonoids and anthraquinones with antioxidant and detoxifying properties.Objective: This study evaluated the methanolic extract of R. vasicarius (MERV) for hepatoprotective activity in rats against CCl 4 -induced liver damage. Materials and methods: The whole plant extract was prepared and investigated for its hepatoprotective activity. Rats were pretreated with MERV (100 and 200 mg/kg, p.o.) for 7 d prior to the induction of liver damage by CCl 4 . Animals were then sacrificed 24 h after CCl 4 administration for the biochemical (AST, ALT, and ALP activity in serum; lipid peroxidation (LPO) and glutathione (GSH) levels in liver tissue) and histological analyses. Results: CCl 4 -induced hepatotoxicity was confirmed by an increase (p50.05) in serum AST (4.55-fold), ALT (3.51-fold), and ALP (1.82-fold) activities. CCl 4 -induced hepatotoxicity was also manifested by an increase (p50.05) in LPO (3.88-fold) and depletion of reduced glutathione (3.14-fold) activity in liver tissue. The multiple dose MERV administration at 200 mg/kg showed promising hepatoprotective activity as evident from significant decrease levels of serum AST (230.01 ± 13.21), serum ALT (82.15 ± 5.01), serum ALP (504.75 ± 19.72), hepatic LPO (3.38 ± 0.33), and increased levels of hepatic glutathione (0.34 ± 0.04) towards near normal. Further, biochemical results were confirmed by histopathological changes as compared with CCl 4 -intoxicated rats. Discussion and conclusion: The results obtained from this study indicate hepatoprotective activity of Rumex plant against CCl 4 -induced liver toxicity; hence, it can be used as a hepatoprotective agent.

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“…1,2) The trichloromethyl radical may bind either at the heme group of CYP or at the active site of the enzyme near the heme group, leading to inactivation of the CYP pathways. 25) In the present study, a significant decrease in the hepatic CYP2E1 protein content and CYP2E1-specific PNP hydroxylase activity was found in the rats treated with CCl 4 alone.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Iridoid Glucosides fromBoschniakia rossicaon Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Ji-shu

Piao

Tian

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity

Cited by 91 publications

References 30 publications

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats

Protective Effect of Iridoid Glucosides fromBoschniakia rossicaon Acute Liver Injury Induced by Carbon Tetrachloride in Rats

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Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity

Cited by 91 publications

References 30 publications

Hepatoprotective effects of Juglans regia extract against CCl4-induced oxidative damage in rats

Hepatoprotective effects of Juglans regia extract against CCl4-induced oxidative damage in rats

Ameliorative effect of methanol extract ofRumex vesicariuson CCl4-induced liver damage in Wistar albino rats

Protective Effect of Iridoid Glucosides fromBoschniakia rossicaon Acute Liver Injury Induced by Carbon Tetrachloride in Rats

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Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Hepatoprotective effects of Juglans regia extract against CCl₄-induced oxidative damage in rats

Ameliorative effect of methanol extract ofRumex vesicariuson CCl₄-induced liver damage in Wistar albino rats