Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways

Weishan, Li; Jiang, Bing‐Hua; Cao, Xianglin; Xie, Yongjiang; Huang, Ting

doi:10.1016/j.cbi.2016.11.021

Cited by 76 publications

(39 citation statements)

References 44 publications

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“…Lycopene is a naturally occurring carotenoid in the tomato (Li et al , 2017). Among the carotenoids, lycopene is one of the major functional components.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical, Microbial, and Sensory Properties of Queso Blanco Cheese Supplemented with Powdered Microcapsules of Tomato Extracts

Jeong

Lee

Ganesan

et al. 2017

Korean Journal for Food Science of Animal Resources

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The present study examined the physical, chemical, microbial, and sensory characteristics of Queso Blanco cheese supplemented with powdered microcapsules containing tomato extracts (0.5-2.0%) during storage at 7°C for 60 d. The lactic acid bacterial count and lycopene concentrations in Queso Blanco cheese supplemented with powdered microcapsules were significantly higher than those of the control. In a texture analysis, the gumminess, chewiness, and hardness values for Queso Blanco cheese were significantly higher with increasing concentrations of the powdered microcapsules containing tomato extracts. Total short-chain fatty acids in Queso Blanco cheese supplemented with powdered microcapsules containing tomato extracts were not significantly altered compared to the control. Sensory evaluation scores for the yellowness, tomato taste, and firmness of Queso Blanco cheese were significantly higher after supplementation with powdered microcapsules containing tomato extracts.

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“…Lycopene is a naturally occurring carotenoid in the tomato (Li et al , 2017). Among the carotenoids, lycopene is one of the major functional components.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical, Microbial, and Sensory Properties of Queso Blanco Cheese Supplemented with Powdered Microcapsules of Tomato Extracts

Jeong

Lee

Ganesan

et al. 2017

Korean Journal for Food Science of Animal Resources

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“…Furthemore, several studies have reported that spinosad exposure may cause DNA fragmentation and chromosomal aberration in rats (Ahmed 2012;Mansour, Mossa, & Heikal, 2008). Oxidative stress can be defined as the state of imbalance between prooxidant challenge and antioxidant systems, attributing to the overproduction of ROS that exceed the capacity of antioxidant defense systems (Baysal et al, 2016;Li, Jiang, Cao, Xie, & Huang, 2017). Various environmental stresses are known to enhance the ROS production, such as ultraviolet radiation, heavy metals and pesticide remnant, disturbing the cellular redox homeostasis (Ma et al, 2014;Shahid et al, 2014;Thévenod, Friedmann, Katsen, & Hauser, 2000).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells

Yang

Gao

et al. 2017

Food and Agricultural Immunology

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Spinosad, a neurotoxic insecticide, is widely used for crop protection. In order to elucidate the effects of spinosad on oxidative stress and genotoxicity in Sf9 cells, the levels of lipid peroxidation, the activity of antioxidative enzymes, and DNA damage were measured. The results showed that spinosad caused a time-dependent increase in the formation of malondialdehyde and decrease in the activity of superoxide dismutase and catalase. Further studies confirmed that spinosad induced 8-oxoguanine accumulation in Sf9 cells, which is accompanied by increased expression of DNA repair enzymes (OGG1 and MTH1). The neutral comet assay revealed that spinosad induced significant timerelated increases of DNA double-strand breaks in Sf9 cells. Our results indicate that spinosad effectively induced oxidative stress and DNA damage in Sf9 cells. ARTICLE HISTORY

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“…Although several caspases are involved in apoptosis, caspase-9 (initiator-caspase) and caspase-3 (executioner-caspase) are highly expressed during hypoxia (ischemic) and oxidative stress conditions [22] especially in MI [23,24]. Thus, the levels of these major cardiac apoptotic markers were determined in the present study.…”

Section: Discussionmentioning

confidence: 93%

Protective effect of ginsenoside Rd against isoproterenolinduced myocardial infarction in Wistar rats

Sun¹,

Li²,

Lu³

2019

Trop. J. Pharm Res

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Purpose: To investigate the protective effect of ginsenoside Rd (GRd) against isoproterenol (ISO)induced myocardial infarction in a rat model. Methods: Forty healthy male rats were equally divided into four groups (10/group). Rats in the control group received only saline, whereas rats in GRd group were intraperitoneally (i.p.) injected GRd at a dose of 50 mg/kg body weight (b.wt.) for 14 days. The other two groups were ISO-treated rats. One group (MI model) received ISO at a dose of 80 mg/kg b.wt i.p. for 2 days, while the other group (GRd + ISO group) was pretreated with GRd at a dose of 50 mg/kg for 14 days prior i.p. administration of the same dose of ISO. Results: Treatment with GRd (for 14 days) prior to ISO exposure resulted in significant increase in the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) as well as significant decreases in heart-to-body weight ratio, infarct size, inflammatory markers {tumour nectosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6)}, relative to ISO-treated rats (p > 0.05). In addition, prior exposure to ISO led to significant elevation in malondialdehyde (MDA), cardiac troponin T (cTnT), creatine kinase (CPK), lactate dehydrogenase (LDH) and apoptotic markers (caspase-3 and caspase-9). However, pre-treatment with GRd reversed the ISO-induced histopathological changes (necrosis/oedema and altered cardiac fibres) in cardiac tissue. Conclusion: These results demonstrate that GRd ameliorates ISO-induced cardiotoxicity in rats via upregulation of the activities of antioxidants, and suppression of inflammatory and apoptotic biomarkers. Thus, GRd has cardio-protective properties.

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Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways

Cited by 76 publications

References 44 publications

Physicochemical, Microbial, and Sensory Properties of Queso Blanco Cheese Supplemented with Powdered Microcapsules of Tomato Extracts

Physicochemical, Microbial, and Sensory Properties of Queso Blanco Cheese Supplemented with Powdered Microcapsules of Tomato Extracts

Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells

Protective effect of ginsenoside Rd against isoproterenolinduced myocardial infarction in Wistar rats

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