Protective Effect of Mesna on Intestinal Ischemia-reperfusion Injury by Nitric Oxide and Arginase in an Experimental Rat Model

Sanal, Filiz; Uluçam, Enis; İNAN, Mustafa; Cerkezkayabekir, Aysegul; Bakar, Elvan

doi:10.3923/ijp.2017.1038.1046

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…In retinal ischemia-reperfusion injury models, ARG-2 deletion leads to significantly reduced glial activation, reactive oxygen species formation and cell death by necroptosis leading to decreased ganglion cell loss, microvascular degeneration and preserved retinal morphology [8]. Similarly, in the small intestine [91] and liver [92], ARG blockade been shown to increase L-arginine bioavailability resulting in less injury in the latter following ischemia-reperfusion. Essentially, in reperfusion models of organs other than the brain, ARG upregulation following injury appears to have detrimental effects.…”

Section: Arg Response After Brain Injurymentioning

confidence: 99%

The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia

et al. 2018

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Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in the adult might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in developing brain requires exploring new mechanisms. Critical determinants of neuronal survival after HI are the extent of vascular dysfunction, inflammation, and oxidative stress, followed later by tissue repair. The key enzyme of these processes in human body is arginase (ARG) that acts via bioavailability of nitric oxide, and synthesis of polyamines and proline. ARG is expressed throughout the brain in different cells, however, little is known about the effect of ARG in pathophysiological states of brain, especially hypoxia-ischemia. Here, we summarize the role of ARG during neurodevelopment, as well as in various brain pathologies.

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Section: Arg Response After Brain Injurymentioning

confidence: 99%

The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia

et al. 2018

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“…These beneficial outcomes of Mesna were built on inspection of the lung that demonstrated about normal structure apart from few mild changes. Similarly, Mesna could effectively counteract injury induced by I–R in the intestine 69 , liver 70 , spinal cord 71 , and kidney 72 .…”

Section: Discussionmentioning

confidence: 99%

Mesna ameliorates acute lung injury induced by intestinal ischemia–reperfusion in rats

El-Baset

El-Haleem

Abdul-Maksoud

et al. 2021

Sci Rep

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The lung is severely affected by intestinal ischemia–reperfusion (I–R) injury. Mesna, a thiol compound, possess anti-inflammatory and antioxidant properties. We aimed in the present work to explore the potential beneficial effects of Mesna on the acute lung damage mediated by intestinal I–R in a rat model. Forty male adult albino rats were randomly separated into; control, intestinal I–R, Mesna I and Mesna II groups. Mesna was administered by intraperitoneal injection at a dose of 100 mg/kg, 60 min before ischemia (Mesna I) and after reperfusion (Mesna II). Arterial blood gases and total proteins in bronchoalveolar lavage (BAL) were measured. Lung tissue homogenates were utilized for biochemical assays of proinflammatory cytokines and oxidative stress markers. Lung specimens were managed for examination by light and electron microscopy. Our results revealed that Mesna attenuated the histopathological changes and apoptosis of the lung following intestinal I–R. Mesna also recovered systemic oxygenation. Mesna suppressed neutrophil infiltration (as endorsed by the reduction in MPO level), reduced ICAM-1 mRNA expression, inhibited NF-κB pathway and reduced the proinflammatory cytokines (TNF-α, IL-1β and IL-6) in the lung tissues. Mesna maintained the antioxidant profile as evidenced by the elevation of the tissue GPx and SOD and down-regulation of HSP70 immune-expressions. Accordingly, Mesna treatment can be a promising way to counteract remote injury of the lung resulted from intestinal I–R.

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“…Although mesna has been used effectively against IFS-induced cystitis, however; the symptoms of HC persist clinically in about 30% of cases. 10 Mesna cannot eradicate IFS-induced HC, which arises from direct contact of the toxic acrolein with the UB mucosa and induces the production of free radicals, RNS and ROS. Therefore, the protective agents against molecular damage in cases of HC should include various antioxidative enzymatic defense systems such as superoxide dismutase (SOD) and non-enzymatic antioxidants such as celery (Apium graveolens).…”

Section: Introductionmentioning

confidence: 99%