Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells

Hsieh, Tusty‐Jiuan; Liu, Tsan‐Zon; Chia, Yi‐Chen; Chern, Chi-Liang; Lu, Fung‐Jou; Chuang, Man-chun; Mau, Shin-Yi; Chen, Shiang-Hsun; Syu, Yu-Hua; Chen, Ching‐Hsein

doi:10.1016/j.fct.2004.01.008

Cited by 125 publications

(83 citation statements)

References 29 publications

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“…Reducing reactive oxygen species in the body is one of main efforts towards protection of various diseases such as aging process, cancer, diabetes and neurodegenerative diseases (Hsieh et al, 2004). Many natural products including flavonoids, cumarins, polyols have been studied for the characterization and the development as antioxidative reagents (Finkel and Holbrook, 2000;Lee et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The radical scavenging effect and inhibition of LPO have been reported as major activities of meGAL (Westenburg et al, 2000;Galato et al, 2001;Cho et al, 2003). In addition, meGAL possesses the biological activities including antiplatelet activity (Lim et al, 2004), protection of DNA damaging against oxidative stress (Hsieh et al, 2004), protection of lung injury induced by phosgene (Sciuto and Moran, 2001), attenuation of diabetic oxidative stress (Cho et al, 2004) and antiapoptotic activity (Sohi et al, 2003). However, radical scavenging ability of meGAL has been a main focus to explain its protective function against oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

Whang

Park²,

Ham³

et al. 2005

Exp Mol Med

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

Whang

Park²,

Ham³

et al. 2005

Exp Mol Med

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“…Of these, methyl gallate has been demonstrated to possess antioxidant activity and to inhibit lipid peroxidation (Wu et al 1998;Mei et al 1999;Westenburg et al 2000;Galato et al 2001). Hsieh et al (2004) demonstrated that methyl gallate extracted from TSR could suppress H 2 O 2 -mediated oxidative stress and DNA damage via scavenging of intracellular reactive oxygen species, inhibiting lipid peroxidation and preventing the depletion of intracellular glutathione level in Madin -Darby canine kidney cells (Hsieh et al 2004).…”

Section: ·75 £ 10mentioning

confidence: 99%

Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice

et al. 2006

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The purpose of the present study was to examine the effects of Toona sinensis Roemor extracts on antioxidative activities, brain morphological changes and cognitive ability. In an in vitro study, the antioxidant capacities of water extracts from Toona sinensis Roemor leaf (TSL), root (TSR) and bark (TSB) were evaluated by an a,a-diphenyl-b-pricryl-hydrazyl radical-scavenging test. The results showed that the scavenging activities of all Toona sinensis Roemor extracts were over 80 % at a concentration of 0·625 mg/ml. In an in vivo study, 3-month-old male senescence-accelerated-prone 8 mice were used as the tested subjects and fed four different diets: casein diet or casein diet supplemented with 1 % TSL, TSR or TSB extract for 12 weeks. The results showed that the mice supplemented with Toona sinensis Roemor extracts demonstrated significantly less amyloid b-protein deposition and lower levels of thiobarbituric acid-reactive substances than the control group. All Toona sinensis Roemor diet groups also showed better active shuttle avoidance responses, and higher superoxide dismutase, catalase and glutathione peroxidase activities, than the control group. It can thus be concluded that supplementation with either TSL, TSR or TSB extract could not only reduce the incidence of ß-amyloid plaques, but also improve learning and memory ability in senescence-accelerated-prone 8 mice. This might be due to the beneficial effects of Toona sinensis Roemor extracts on promoting the antioxidative defence system. Free radical-mediated reactions and reactive oxygen species have been proposed to be the major contributors to the pathological processes of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Alzheimer's disease is accompanied by cognitive impairment as well as involving the pathological build-up of extracellular, vascular and parenchymal deposits of a 40 -42-amino peptide, amyloid b-protein. It has been demonstrated that oxidative damage increased both in the brains of individuals with Alzheimer's disease (Friedlich & Butcher, 1994;Smith et al. 1997;Montine et al. 1999) and in b-amyloid plaque-forming transgenic mouse models of Alzheimer's disease Pappolla et al. 1998;Smith et al. 1998), suggesting that an elevated level of amyloid b-protein is sufficient to stimulate oxidative damage. In an in vitro study, a direct application amyloid b-protein to neuronal cells increased the production of H 2 O 2 (Behl et al. 1994), leading to amyloid b-protein neurotoxicity, which could be prevented by the use of antioxidants (Behl et al. 1992;Goodman et al. 1994).The development of rodent models of Alzheimer's disease will elucidate some important aspects of the aetiology of the disease and the development of therapeutic methods. In a murine model of accelerated senescence (senescence-accelerated mouse), severe senile amyloidosis is one of the most characteristic age-associated disorders (Higuchi et al. 2004). Ohta et al. (1989) and Flood & Morley (1993) have reported that the senescence-accelerated-prone 8 (SAM...

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“…In response to the generation of ROS, the host cells produce antioxidants that act to detoxify ROS. However, when the balance of pro-oxidants and anti-oxidants is disturbed, the host cells undergo auto oxidative stress, which causes DNA damage (Hsieh et al, 2004). Thus, the appearance of the anti-oxidant encoding cDNAs in the present ESTs may have been to protect against oxidative damage triggered by the mitogens.…”

Section: Construction Of Cdna Librarymentioning

confidence: 99%

Characterization of Expressed Genes in Kidney Cells of Japanese Flounder Paralichthys olivaceus Following Treatment with ConA/PMA and LPS

2004

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Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells

Cited by 125 publications

References 29 publications

Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice

Characterization of Expressed Genes in Kidney Cells of Japanese Flounder Paralichthys olivaceus Following Treatment with ConA/PMA and LPS

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