Protective Effect of Mildronate against Toxic Influence of Mercury(II) Chloride on Cultured Neuroblastoma Cells

Sokurenko, L. M.; Chaikovskii, Yu. B.

doi:10.1007/s11062-014-9440-7

Cited by 8 publications

(2 citation statements)

References 4 publications

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“…Flavonoids that exhibit antioxidant properties inhibiting the formation of free radicals [8][9][10][11][12][13] are of particular importance in the prevention of cardiovascular diseases. One flavonoid already in pharmacology use is Quercetin.…”

Section: Introductionmentioning

confidence: 99%

Protective role of quercetinum in mercury exposure cardiotoxity

Kaminsky

2019

Current Issues in Pharmacy and Medical Sciences

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The article describes the remediation of myocardium structure characteristics provided by Quercetinum under the influence of 0.01 LD50 mercury chloride (II) in rats at chronic exposure. Ultrastructural and metabolic reorganization of myocardium tissue was studied by electron microscopic and histochemical techniques. Quercetinum reduces energy imbalance in the myocardium, shows membrane-stabilizing activity, and promotes stabilization and normalization of the function of membranes by direct biochemical interaction of the membrane organelles of the body’s cells.

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Section: Introductionmentioning

confidence: 99%

Protective role of quercetinum in mercury exposure cardiotoxity

Kaminsky

2019

Current Issues in Pharmacy and Medical Sciences

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“…For instance, the neuroprotective effect of Thiotriazoline, Mildronate and Magnesium B6 in mercury toxication was found [21,22]; it was shown that under subchronic mercury exposure and combined pharmacological protection with Unithiol and Quercitin, myocardial structures restored due to the positive effect on the hemomicrocirculatory bed [10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of protective effect of Thiocetam drug by morphological changes in the heart and vessels after administration of lead nanoparticles of various sizes (experimental study)

et al. 2019

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Introduction of nanotechnologies to the modern industry gave rise to new challenges. The issue of development and implementation of recommendations regarding the prevention of potential negative impact of lead nanoparticles on population health is of particular importance. The locally manufactured drug Thiocetam which possesses nootropic, antiischemic, antioxidative and membrane stabilizing properties has drawn our attention. The research aimed at studying the protective effect of Thiocetam in Wistar rats with simulated subchronic toxic effect of lead compounds of various sizes (by morphological changes in the heart and vessels). The experiments were conducted on Wistar rats (mean body weight of 160-180 g). Colloidal solutions of lead sulphide obtained by chemical synthesis with the use of sodium polyphosphate stabilizer, (PbS) with the mean size of 26-34 nm (1-PbS) and 50-80 nm (2-PbS), and lead nitrate Pb(NO3)2 (3-Pb) in the ionic form were used in simulating the toxic effect, while normal saline solution was administered to the control group. The studied substances were injected (intraperitoneally daily 5 times a week) in a dose of 0.94 mg/kg (in lead equivalent). The toxic effects were evaluated after 60 injections (three months) and one month after the discontinuation of exposure with and without Thiocetam. The drug Thiocetam in the dose of 250 mg/kg had been administered to rats intragastrically on an empty stomach daily for one month. Histological slides of the rats’ myocardium and aortal wall were studied and morphometric analysis and statistical processing performed. In the postexposure recovery period (PEP) period a lower degree of interstitial swelling and myocardial blood vessel filling was observed, which was considered to be a regression of damage. After the administration of Thiocetam a pronounced transverse striation of cardiomyocytes, the density of collagen fibers around cardiomyocytes and microvessels were revealed, which indicated the protective effect of pharmacological correction. However, leukocyte infiltration was also found in the myocardial or aortic microvessels in the experimental groups. Aortic morphometric data revealed no differences between the PbS NPs groups and Pb(NO3)2, although the aortic wall morphology was quite preserved. The use of Thiocetam prevented dystrophic changes in the atrial epicardium and the aortic adventitia, which indicate cytoprotective and connective tissue effects. In the postexposure period without pharmacological correction a tendency to spontaneous recovery of morphological changes of the heart and aortic walls under the influence of PbS NPs and lead nitrate was observed. However, morphometric parameters demonstrate the absence of complete recovery be it with or without Thiocetam.

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The influence of lead nanoparticles on the morpho‐functional changes of rat liver during the postexposure period

Aleksiichuk

Omelchuk

Sokurenko

et al. 2018

Microscopy Res & Technique

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Lead as any heavy metals may be found in soil, water, air, and is used in everyday life. Once in the body, it causes toxic effect, making the liver, which is one of the main organs of detoxification, suffer. Recently, the study of the action of not only ionic forms of lead, but also its nanoparticles, has become topical. The study aims at determining changes in the liver of rats and biochemical changes in their blood both at late term of exposure to nanoparticles of lead compounds and in the post-exposure period. The study was performed on 120 male rats of Wistar line, which were divided into two series, each series containing four groups. The first and the second groups of animals were intraperitoneally injected with colloidal solution of nanoparticles of lead sulfide of 10 and 30 nm in size, and the third group were intraperitoneally injected with a solution of lead nitrate. The fourth group of animals served as control. In the first series, the investigated substances were administered 60 times within 12 weeks. In the second series, after 60-fold administration of the investigated substances, the exposure was discontibued and animals were observed for 6 weeks-overall duration of 18 weeks. Histological, morphometrical and biochemical methods were used. The body weight was reduced in the rats exposed to PbS at week 12 of experiment and in rats exposed to both PbS and Pb(NO ) in the second series. Absolute liver weight increased at week 12 of experiment in all experimental groups. In the second series this value almost reached that of the control level. Relative liver weight in the animals of all experimental groups was higher than that in the control at week 12 of experiment. In the second series this value remained higher in rats exposed to PbS . After 12 weeks of exposure dystrophic changes in the liver were found in all experimental groups. At week 6 after the exposure (the second series) destructive changes in the liver decreased. Total protein, albumin, glucose, total lipids, cholesterol, triglycerides content in blood serum corresponded with morphological data. The experiment has demonstrated that the 12 weeks long exposure to lead nanoparticles had harmful effect on the liver. Within the postexposure 6-weeks period structural changes in the liver and biochemical changes in blood serum decreased. Biochemical changes in blood serum corresponded to the morphological data. By many parameters PbS had more pronounced harmful effect. Toxicity of PbS and Pb(NO ) were comparable.

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Protective Effect of Mildronate against Toxic Influence of Mercury(II) Chloride on Cultured Neuroblastoma Cells

Cited by 8 publications

References 4 publications

Protective role of quercetinum in mercury exposure cardiotoxity

Protective role of quercetinum in mercury exposure cardiotoxity

Evaluation of protective effect of Thiocetam drug by morphological changes in the heart and vessels after administration of lead nanoparticles of various sizes (experimental study)

The influence of lead nanoparticles on the morpho‐functional changes of rat liver during the postexposure period

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