Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity

Fihri, Aicha Fassi; Al-Waili, Noori S.; El-Haskoury, Redouan; Bakour, Meryem; Amarti, Afaf; Ansari, Mohammad Javed; Lyoussi, Badiâa

doi:10.1159/000445610

Cited by 19 publications

(16 citation statements)

References 36 publications

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“…Honey reduced the cardiovascular risk factors and has many effects on several metabolic factors. Recently clinical research was also carried out about honey and concluded that honey provide a defensive effect from lead-induced blood, hepatic renal toxic effects (Fihri et al, 2016).…”

Section: Medicinal Value Of Honeymentioning

confidence: 99%

Honey: Single food stuff comprises many drugs

Khan

Anjum

Rahman

et al. 2018

Saudi Journal of Biological Sciences

127

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Honey is a natural food item produced by honey bees. Ancient civilizations considered honey as a God gifted prestigious product. Therefore, a huge literature is available regarding honey importance in almost all religions. Physically, honey is a viscous and jelly material having no specific color. Chemically, honey is a complex blend of many organic and inorganic compounds such as sugars, proteins, organic acids, pigments, minerals, and many other elements. Honey use as a therapeutic agent is as old as human civilization itself. Prior to the appearance of present day drugs, honey was conventionally used for treating many diseases. At this instant, the modern research has proven the medicinal importance of honey. It has broad spectrum anti-biotic, anti-viral and anti-fungal activities. Honey prevents and kills microbes through different mechanism such as elevated pH and enzyme activities. Till now, no synthetic compound that works as anti-bacterial, anti-viral and anti-fungal drugs has been reported in honey yet it works against bacteria, viruses and fungi while no anti-protozoal activity has been reported. Potent anti-oxidant, anti-inflammatory and anti-cancerous activities of honey have been reported. Honey is not only significant as anti-inflammatory drug that relieve inflammation but also protect liver by degenerative effects of synthetic anti-inflammatory drugs. This article reviews physico-chemical properties, traditional use of honey as medicine and mechanism of action of honey in the light of modern scientific medicinal knowledge.

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Section: Medicinal Value Of Honeymentioning

confidence: 99%

Honey: Single food stuff comprises many drugs

Khan

Anjum

Rahman

et al. 2018

Saudi Journal of Biological Sciences

127

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“…Interestingly, honey ingestion did not cause hypokalemia in spite of increased urine potassium and urine volume. In kidney diseases, Moroccan carob honey has a protective effect against lead-induced toxicity in rats; it ameliorated the elevation of serum creatinine and blood urea nitrogen induced by lead [ 9 ]. In addition, it was demonstrated that honey collected in the United Arab Emirates can protect liver and kidney during acute blood loss, food restriction, and after carbon tetrachloride intoxication [ 10 - 14 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats

Imtara¹,

Al-Waili²,

Bakour³

et al. 2018

Vet World

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Aim:The composition and activity of honey depend on its floral origin. Honey collected from Tulkarm was evaluated for physicochemical property and antioxidant content as well as a diuretic and wound healing activity. Its effect on kidney function was evaluated and compared with furosemide.Materials and Methods:Honey was collected in Tulkarm, Palestine, and its phenol, flavones, and flavonol content were assessed. The antioxidant activity was determined with the use of colorimetric assays, 1,1-diphenyl-2-picrylhydrazyl, ferric reducing antioxidant power, and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid). Two sets of experiments were conducted. First experiment: 18 rats were used for the evaluation of diuretic activity of honey. The rats received either honey or furosemide. Renal function test, uric acid, and serum and urine electrolytes assay were performed. Second experiment: 18 male mice were used to evaluate the wound healing property of honey. Wounds were created on mice skin and treated daily with honey or Madecassol. Measurements of wounds were performed over a period of 12 days.Results:The physical and chemical parameters of Tulkarm honey are within the limits of the European legislation and fulfilling the criteria described in the standard codex for honey. It contains antioxidant compounds and shows antioxidant activity. Oral honey increased creatinine clearance and urine volume, sodium, and chloride without causing hypokalemia or affecting blood urea, uric acid, or serum creatinine level. The diuretic activity of furosemide was associated with hypokalemia. Topical honey application enhanced wound closure when compared with the Madecassol application.Conclusion:The study is the first to report that honey collected from Tulkarm has a considerable diuretic effect without affecting serum electrolytes or kidney function test and exhibits strong antioxidant activity and wound healing property.

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“…The reason for these findings is probably due to the specific conditions of the research units (the hemodialysis patients), but not due to the type of intervention (thyme honey), resulting in no effect of the intervention. Most previous studies that reported the positive effects of honey administration on slightly or significantly elevated hemoglobin levels mainly used amber and dark honeys, such as Manuka, Tualang, Clover and Carob honey (16,17,21). These honeys have high levels of phenolic compounds, minerals (iron, copper, etc) and antioxidant properties, which have hepatoprotective effects and positive effects on red blood cell production by stimulating bone marrow (17).…”

Section: Discussionmentioning

confidence: 99%

“…Most previous studies that reported the positive effects of honey administration on slightly or significantly elevated hemoglobin levels mainly used amber and dark honeys, such as Manuka, Tualang, Clover and Carob honey (16,17,21). These honeys have high levels of phenolic compounds, minerals (iron, copper, etc) and antioxidant properties, which have hepatoprotective effects and positive effects on red blood cell production by stimulating bone marrow (17). The reason for the significant decrease in hemoglobin level in the study by Aliyu et al (2012) in Pakistan can be attributed to the type of honey used, the acacia honey with watery white color (18).…”

Section: Discussionmentioning

confidence: 99%

“…Previous animal studies reported that daily administration of raw honey could improve hematological parameters and increase hemoglobin levels and red blood cell counts (17,16). In addition, honey administration in rats with lead-induced anemia prevented the development of leadinduced anemia, possibly due to elevated serum iron levels and bone marrow stimulation (17). Contrary to previous studies, Aliyu et al (2012) in Pakistan reported that the administration of acacia honey significantly reduced blood hemoglobin levels in rats (18).…”

Section: Introductionmentioning

confidence: 99%

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The effect of thyme honey on anemia in hemodialysis patients

Kiasari

Nobahar

Ghorbani

et al. 2020

NPT

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Background & Aim: Anemia is one of the most common complications of chronic renal failure, which is associated with increased fatigue, dyspnea, depression, malaise, prolonged hospitalization and mortality. Some patients are resistant to erythropoietin therapy. Therefore, the purpose of this study was to determine the effect of thyme honey on anemia in hemodialysis patients. Methods & Materials: The present clinical trial was conducted in 2018 at Kowsar Hospital of Semnan on hemodialysis patients randomly selected with convenience sampling method within two groups of case (n=28) and control (n=27). The case group received thyme honey (33 g) daily for one month. The control group did not consume thyme honey. Blood samples were taken from the patients before and after the intervention with 10-hour fasting and then blood parameters were assessed. Results: The mean ±SD reduction rate in hemoglobin level was 0.46±0.96 in the case group and 0.23±3.15 g/dl in the control group, but no significant difference using independent t-test (P=0.758). The mean±SD reduction rate in hematocrit percentages was 1.20±2.78 in the case group and 0.11±8.53 in the control group, but there is no significant difference between the two groups using independent t-test (P=0.590). Conclusion: Results showed that daily administration of 33 grams of thyme honey had no effect on anemia in hemodialysis patients. Further studies are recommended with modification of the methodology regarding the type, dose, duration and instructions of honey consumption for better results.

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Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity

Cited by 19 publications

References 36 publications

Honey: Single food stuff comprises many drugs

Honey: Single food stuff comprises many drugs

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats

The effect of thyme honey on anemia in hemodialysis patients

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