Protective Effect of Morus alba Leaf Extract on N-Nitrosodiethylamine-induced Hepatocarcinogenesis in Rats

Kujawska, Małgorzata; Ewertowska, Małgorzata; Adamska, Teresa; Ignatowicz, Ewa; Flaczyk, Ewa; Przeor, Monika; Kurpik, Monika; Liebert, Jadwiga Jodynis

doi:10.21873/invivo.10998

Cited by 15 publications

(5 citation statements)

References 13 publications

(17 reference statements)

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“…Among other phenolic acids (GAL, PRO, VAN, FER, SIN) conditioning lowered the CHL and CAF extract concentration. It has been shown that CHL was also dominant in aqueous extracts from other varieties of WML [1,14] and acetone extract from WML-P [6].…”

Section: Bioactive Compoundsmentioning

confidence: 99%

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Functional Properties and Antioxidant Activity of Morus alba L. Leaves var. Zolwinska Wielkolistna (WML-P)—The Effect of Controlled Conditioning Process

et al. 2020

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This study evaluated the effect of adding a new step, termed conditioning, to the traditional processing of leaves from Morus alba var. zolwinska wielkolistna grown in Poland (WML-P). This step, modeled on tea leaves processing, was conducted in a controlled environment on a semi-technical scale. The primary goal was to evaluate the effect of the WML-P conditioning for 1–4 h at 32–35 °C on the content of bioactive compounds (total phenolics, phenolic acids, flavonols, 1-deoxynojirimycin) and antioxidant activity (radical scavenging against DPPH, antioxidant capacity, chelating activity and ferric reducing antioxidant potential) of the lyophilized extracts. For the first time WML-P extracts content was comprehensively characterized by assessing dietary fiber fractions, fatty acids, amino acids, macro- and microelements and chlorophyll content. Compared to the traditional process, adding the conditioning step to WML-P processing resulted in an increased total phenolics content, radical scavenging capacity, ability to quench 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and iron-chelating ability in the lyophilized extracts. The beneficial effect depended on conditioning time. The highest flavonols and phenolic acids content were found after 2-h conditioning. We concluded that adding a 2-h conditioning step to traditional WML-P processing results in getting WML-P lyophilized extract with increased bioactive compounds content and high antioxidant activity.

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Section: Bioactive Compoundsmentioning

confidence: 99%

“…WML products consumed with a diet are thought to protect against liver cancer, to prevent obesity-related non-alcoholic fatty liver, hypolipidemic or lipid-regulating properties in blood protect against atherosclerosis, to show anti-aggregative properties in platelet and anti-inflammatory effects or to reduce anxiety [6,7].…”

Section: Introductionmentioning

confidence: 99%

Functional Properties and Antioxidant Activity of Morus alba L. Leaves var. Zolwinska Wielkolistna (WML-P)—The Effect of Controlled Conditioning Process

et al. 2020

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“…Therapeutic properties of white mulberry leaves (WML) have previously been utilized in the Far East Medicine. Presently, apart from gardening and forestry, they have been applied in food production (PRZEOR & FLACZYK, 2016;ZOU, 2015), as they are non-toxic to the human organism (KUJAWSKA et al, 2016). Positive outcomes of WML consumption have been demonstrated with regard to, among others, diabetes, hyperlipidemia, eye and skin diseases, obesity, atherosclerosis, liver cancer (BUTT et al, 2008;IQBAL et al, 2012;QIN et al, 2013).…”

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confidence: 99%

Air-drying temperature changes the content of the phenolic acids and flavonols in white mulberry (Morus alba L.) leaves

et al. 2019

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The white mulberry leaves are typically available on the market in dried or encapsulated form. It was assumed in the study that appropriate drying of leaves of the white mulberry is significant for obtaining intermediate products with high content of compounds having anti-oxidative activity. The purpose of the study was to determine the influence of the temperature of mulberry leaves air drying on the content of phenolic acids and flavonols. It has been determined that the content of these compounds in the leaves depended on the drying temperature. Drying at 60 °C favored release of phenolic acids and flavonols from complexes and/or formation of new compounds. Their total content was 22% higher than in leaves dried at 30 °C. Drying at 90 °C reduced the phenolic acid and flavonol content by 24%. The most favorable drying temperature was 60 °C.

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“…M. alba L. has been used worldwide in traditional medicine for the treatment of various diseases from ancient times to the present ( 12 , 15 ). Previous studies have indicated that M. alba L. possesses various pharmacological properties, including antimicrobial ( 16 ), antioxidant ( 17 ), antitumor ( 18 ), anti-obesity ( 19 ), antihypotensive ( 20 ), neuroprotective ( 21 , 22 ), and antidiabetic ( 23 , 24 ) actions. In addition, our previous studies indicated that the extracts and components of M. alba L. fruit water extract were safe ( 25 ), immunostimulatory ( 10 , 12 , 26 ), and had indirect anticancer activity by enhancing immune responses mediated by TLR4 signaling ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L.

Chang¹,

Koo²,

Lee³

et al. 2018

Food & Nutrition Research

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BackgroundThe innate immune system plays a crucial role in the initiation and subsequent direction of adaptive immune responses, as well as in the removal of pathogens that have been targeted by an adaptive immune response.ObjectiveMorus alba L. was reported to have immunostimulatory properties that might protect against infectious diseases. However, this possibility has not yet been explored. The present study investigated the protective and immune-enhancing ability of M. alba L. against infectious disease and the mechanisms involved.DesignTo investigate the immune-enhancing effects of M. alba L., we used a bacterial infection model.Results and discussionsThe lifespan of mice infected with a lethal dose of Salmonella typhimurium (1 × 107 colony forming units – CFU) was significantly extended when they were administered M. alba L. Furthermore, M. alba L. activated macrophages, monocytes, and neutrophils and induced Th1 cytokines (IL-12, IFN-γ, TNF-α) in mice infected with a sublethal dose (1 × 105 CFU) of S. typhimurium. M. alba L. significantly stimulated the uptake of bacteria into peritoneal macrophages as indicated by increased phagocytosis. Peritoneal macrophages derived from C3H/HeJ mice significantly inhibited M. alba L. induced NO production and TNF-α secretion compared with peritoneal macrophages derived from C3H/HeN mice.ConclusionsThese results suggest that the innate immune activity of M. alba L. against bacterial infection in mice occurs through activation of the TLR4 signaling pathway.

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Protective Effect of Morus alba Leaf Extract on N-Nitrosodiethylamine-induced Hepatocarcinogenesis in Rats

Cited by 15 publications

References 13 publications

Functional Properties and Antioxidant Activity of Morus alba L. Leaves var. Zolwinska Wielkolistna (WML-P)—The Effect of Controlled Conditioning Process

Functional Properties and Antioxidant Activity of Morus alba L. Leaves var. Zolwinska Wielkolistna (WML-P)—The Effect of Controlled Conditioning Process

Air-drying temperature changes the content of the phenolic acids and flavonols in white mulberry (Morus alba L.) leaves

Activation of macrophage mediated host defense against Salmonella typhimurium by Morus alba L.

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