Protective effect of N-acetylcysteine on reduced glutathione, reduced glutathione-related enzymes and lipid peroxidation in methanol intoxication

Skrzydlewska, Elżbieta; Farbiszewski, R

doi:10.1016/s0376-8716(99)00040-x

Cited by 39 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This circulating cysteine may enter renal cells and serve as a precursor for glutathione production. In fact, several studies have found that NAC prevents glutathione depletion (43,44). The relevance for the kidney is suggested by the demonstration of glutathione depletion in ischemia reperfusion injury (46,47).…”

Section: Biological Actions Of Nacmentioning

confidence: 99%

N-Acetylcysteine in the Prevention of Contrast-Induced Nephropathy

Fishbane¹

2008

Clinical Journal of the American Society of Nephrology

154

View full text Add to dashboard Cite

Section: Biological Actions Of Nacmentioning

confidence: 99%

N-Acetylcysteine in the Prevention of Contrast-Induced Nephropathy

Fishbane¹

2008

Clinical Journal of the American Society of Nephrology

154

View full text Add to dashboard Cite

“…Upon deacetylation, NAC becomes L-cysteine, entering cells where it may serve as a precursor for GSH synthesis. Indeed, NAC has been shown to prevent GSH depletion and/or to increase hepatic GSH levels (77,(85)(86)(87). In the kidney, glutathione has been shown to be reduced in the ischemia/reperfusion model of acute renal failure (88,89).…”

Section: Biologic Actions Of N-acetylcysteinementioning

confidence: 99%

N-Acetylcysteine In The Prevention Of Radiocontrast-Induced Nephropathy

Fishbane¹,

Durham²,

Marzo³

et al. 2004

Journal of the American Society of Nephrology

177

122

View full text Add to dashboard Cite

“…Then, there are many reports on the increase of the cell membrane permeability by GSH derivatives. 40,41) Since theanine has the increase effect of GSH in a liver cell as well as them, the effect on a chronic alcohol-induced liver injury will be also expected. Moreover, it is shown that the reduction of GSH in a mitochondria raises sensitivity to tumor necrosis factor-alpha (TNF-a), and an ethanol-induced liver injury advances.…”

Section: Discussionmentioning

confidence: 99%

Effects of Theanine on Alcohol Metabolism and Hepatic Toxicity

Sadzuka

Inoue

Hirooka

et al. 2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Theanine (Fig. 1), a major amino acid in green tea, is a umami (the fifth taste sensation)-component of tea and is contained 2-3% in tea leaves.1,2) Theanine is a glutamate derivative and is used extensively as supplements and beverages, because it has a brain nerve function such as a relaxing effect due to inducing alpha waves. [3][4][5][6] But there are few reports about pharmacological action of theanine in comparison with catechin or caffeine, major tea components, and its effects on living individuals have not revealed closely. In recent studies, we showed that theanine enhanced doxorubicin (DOX), an anthracycline derivative, induced antitumor activity, and confirmed that this action contributed to the increase in the concentration of DOX in tumor with inhibition of the efflux of DOX from tumor cells. [7][8][9][10][11][12][13] Besides, theanine induced the elevation of glutathione (GSH) level attributable to the increase of glutamate in the liver of mice, namely, theanine would reduce the adverse reaction of DOX. Although GSH in tissues are kept constant by homeostasis, whereas was decreased by disease or medicine or age.14) The usefulness of theanine was shown when the GSH level in liver decreased by the hepatic load of DOX. Furthermore, it was suggested that GSH level would increase by the metabolism of theanine. Thus, theanine was thought to be effective against tissue changes with GSH level reduction.On the other hand, it is suggested excessive uptake of alcohol causes a production of free radicals, a decrease of GSH level, and an increase in the amount of lipid peroxide (LPO) in liver, and shifting to an alcoholic liver injury. [15][16][17][18] In the liver, theanine is metabolized, converted glutamate, and induced to increase GSH level. 19) Namely, theanine may be expected to affect on to an alcoholic liver injury. Then, aiming at the prevention and medical treatment of a hepatic toxicity by the food components with little toxicity, we have studied the effect of theanine on ethanol metabolism and hepatic toxicity using ethanol single-administrated mice. To evaluate the effect of theanine on ethanol metabolism and its toxicity, theanine was intraperitoneally injected and ethanol was orally administered. MATERIALS AND METHODSMaterials Alcohol Dehydrogenase (ADH, EC 1.1.1.1) was purchased from Sigma Chemical Co. (St. Louis, MO, U.S.A.). The other chemicals used in this study were of the highest purity available.Animals Male CDF 1 mice (5 weeks of age and weighing 20-25 g) were obtained from Japan SLC Inc. (Hamamatsu, Japan). The animals were housed in a room maintained at 25Ϯ1°C and 55Ϯ5% relative humidity, and were given free access to regular chow pellets and water.Change of Ethanol Distribution in the Blood after Theanine Administration Subjects were assigned to one of three groups. One group was the ethanol alone group, which was administrated only 50% ethanol (3.0 g/kg, p.o.). The second group was the theanine pre-administrated group, which was administrated theanine (100 mg/kg, i.p.) before 1 h of ...

show abstract

Protective effect of N-acetylcysteine on reduced glutathione, reduced glutathione-related enzymes and lipid peroxidation in methanol intoxication

Cited by 39 publications

References 34 publications

N-Acetylcysteine in the Prevention of Contrast-Induced Nephropathy

N-Acetylcysteine in the Prevention of Contrast-Induced Nephropathy

N-Acetylcysteine In The Prevention Of Radiocontrast-Induced Nephropathy

Effects of Theanine on Alcohol Metabolism and Hepatic Toxicity

Contact Info

Product

Resources

About