Protective effect of Naoshuning in a rat brain ischemia-reperfusion damage model

Zhang, Meikui; Shen, Shao-Qing; Liu, Ruo-zhuo; Chen, Tingting

doi:10.5897/ajpp11.407

Afr. J. Pharm. Pharmacol.

2012

DOI: 10.5897/ajpp11.407

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Protective effect of Naoshuning in a rat brain ischemia-reperfusion damage model

Meikui Zhang¹,

Shao-Qing Shen²,

Ruo-zhuo Liu³

et al.

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Effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens

Hou¹,

Li²,

Shi³

et al. 2012

Afr. J. Pharm. Pharmacol.

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To investigate the effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens, Angelica polysaccharide was used for the study of immunity and hematinic mechanism in order to provide basis for clinical reference. In this experiment, three gradient dosages (50, 100, 150 mg/kg body weight) of Angelica polysaccharide were drenched to the control group and the anemia groups, respectively. The anemia chickling model was made by abdominal injection of cyclophosphamide (CY) for 6 days (80 mg/kg•day). Red blood cell-C3b receptor (RBC-CR1) and red blood cell-immune complex (RBC-IC) rosette rates were measured and analyzed. Ectogenetic semi-solid culture medium of bone marrow hemopoietic progenitor cells was used to observe Angelica polysaccharide and separated serum from Angelica polysaccharide treatment on the proliferation of colony-forming unit-erythrocyte (CFU-E), burst-forming unit-erythrocyte (BFU-E) and colony-forming unit-granulocyte macrophage (CFU-GM). The results showed that Angelica polysaccharide can significantly increase RBC-CR1 rosette rate in the healthy chicken groups (p<0.01), but had no more effect on RBC-IC rosette rate (p>0.05). At the same time, Angelica polysaccharide can restore the RBC-CR1 rosette rate and the RBC-IC rosette rate caused by cyclophosphamide to the normal level. Serum containing Angelica polysaccharide can significantly facilitate the proliferation on CFU-E (p<0.01), BFU-E (p<0.01) and CFU-GM (p<0.01), but Angelica polysaccharide had no more direct proliferation on CFU-E, BFU-E and CFU-GM. This indicated that Angelica polysaccharide had the proliferation on hemopoietic progenitor cells of marrow by the change of hemopoietic factor.

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Effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens

Hou¹,

Li²,

Shi³

et al. 2012

Afr. J. Pharm. Pharmacol.

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show abstract

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Protective effect of Naoshuning in a rat brain ischemia-reperfusion damage model

Cited by 1 publication

References 9 publications

Effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens

Effects of Angelica polysaccharide on erythrocyte immunity and marrow hematopoiesis in chickens

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