Protective Effect of Naringin against Pylorus Ligation-induced Esophagitis in Male Wistar Rats

Abstract

Shalini, et al.: Naringin and Pylorus Ligation-induced Esophagitis in RatsThe present study was undertaken to evaluate the effect of naringin, a naturally occurring flavonoid, on experimental esophagitis in Wistar rats. Animals divided into six groups and received carboxymethyl cellulose (0.25%, 3 ml/kg, sham control), standard pantoprazole (30 mg/kg) and naringin (100, 200 and 300 mg/kg) for 7 d orally and subjected to pylorus and forestomach ligation. All animals were sacrificed after 8 h and evaluated for various physiological parameters like total acidity, free acidity, gastric pH, volume of gastric juices and esophagitis index. Esophagitis regions were further subjected to estimation of various oxidative stress parameters including thiobarbituric acid reactive substances, glutathione, catalase and superoxide dismutase. Later, histopathology and scanning electron microscopy of esophagitis regions were also performed to evaluate protective action of naringin. Results revealed that treatment with pantoprazole and naringin significantly inhibited the gastric secretion, total acidity and esophagitis index. Various oxidative stress parameters were restored to normal level in the treatment groups. Histopathology and scanning electron microscopy analyses demonstrated the protective action of naringin as evidenced by normal tissue architecture of esophagitis regions. These findings indicate the potential of naringin against esophagitis.

Combined therapy of gabapentin with pantoprazole exhibited better protective action against forestomach and pylorus ligation–induced gastric esophageal reflux disease in albino Wistar rats

“…A significant reduction in gastric volume, total acidity, and esophagitis index was observed in pantoprazoletreated group 3 as it was expected ( Table 2). 21 Similarly, significant changes in volume gastric juice, total acidity, and esophagitis index were observed in group 4 animals treated with monotherapy of gabapentin when compared to the toxic control group. It would be pertinent to mention here that monotherapy with gabapentin provided a more significant reduction in the volume of gastric juice and total acidity in comparison to monotherapy with pantoprazole.…”