Protective effect of Nigella sativa against paracetamol induced hepatic and renal damages

Hasan, M; Khan, Rahat; Nasiruddin, Mohammad; Khan, Aijaz Ahmed

doi:10.18203/2319-2003.ijbcp20150029

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…(22) Hasan et al worked on acetaminophen induced nephrotoxicity resulting in glomerular shrinkage, tubular distortion and tubular dilatation and concluded that both aqueous and ethanolic extract of NS can normalize these pathological alterations. (23) This protection against drug toxicity is brought about by its antioxidative activity and prostaglandins' synthesis which improves renal perfusion by vasodilation. (24) Concluding remarks of a recent meta-analysis stated that NS has definitive hepato-reno-protective role if the dose and duration of drug intake is optimal.…”

Section: Resultsmentioning

confidence: 99%

Doxorubicin Induced Histomorphometric Changes in the Kidney of Albino Rats and Protective Role of Nigella Sativa

Baloch¹,

Zafar²,

Ullah³

et al. 2024

Int J Front Sci

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Objective: Doxorubicin is presently a leading antineoplastic drug with promising efficacy. This study was designed to investigate the histological effects of doxorubicin toxicity on rat kidneys and how much protection is provided by Nigella Sativa. Materials & Methods: A randomized controlled trial conducted on thirty adult male wistar rats divided randomly into three equal groups. Group A served as a control. Group B was injected with weekly intraperitoneal injections of doxorubicin at a dose of 3mg/kg b.w. Group C rats received doxorubicin along with nigella sativa at a dose of 1000mg/kg b.w. orally daily. At the end of these interventions, animals were sacrificed and kidneys were removed for the purpose of histological staining. Renal glomerular and tubules related histopathological parameters were assessed qualitatively as mild, moderate & severe. Renal glomerular diameter was digitally measured by microscope. Ethical approval was taken from Ethical Committee, Jinnah Postgraduate Medical Centre (JPMC), Karachi. All the parameters were statistically analyzed. Results: Group B rats’ renal tissue was adversely affected by the drug showing marked necrosis of tubules and the glomeruli along with interstitial cells’ infiltration. Glomerular diameter was also significantly decreased in group B as compared to group A. These histological features in group C rats’ renal tissue were milder and glomerular diameter was close to that of group A. Conclusion: According to our study doxorubicin treatment proved noxious for the renal tissue, both tubules and glomeruli, while nigella sativa significantly competed against these pathological alterations.

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Section: Resultsmentioning

confidence: 99%

Doxorubicin Induced Histomorphometric Changes in the Kidney of Albino Rats and Protective Role of Nigella Sativa

Baloch¹,

Zafar²,

Ullah³

et al. 2024

Int J Front Sci

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“…The oil extracted from N sativa is mostly consisted of linoleic acid, oleic, dihomolinoleic acid, palmitic acid, stearic acid, myristic acid, stroles and eicodadienoic acid. It plays an important role in prevention of many diseases due to its anti-cancer, hepatoprotective, anti-bacterial, anti-inflammatory and antioxidant activities [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Effect of Fosamax on the duodenal mucosa in adult male albino rats and the possible protection by nigella sativa oil: a histological and immunohistochemical study

Kassab

2019

Egyptian Journal of Histology

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Background: Fosamax, an oral bisphosphonate, is the most commonly prescribed drug for the treatment of various bones diseases. However, Fosamax therapy is associated with gastrointestinal toxicity that influences the treatment compliance. Nigella sativa (N sativa) is an annual herbaceous plant and have been safely used as a natural remedy in Egypt. It has a wide range of pharmacological activities and a proposed role in combating many gastrointestinal disorders. Aim: This work aimed to study the effect of Fosamax on the histological structure of the duodenal mucosa of albino rats and to evaluate the possible protective role of nigella sativa oil. Materials and methods: Forty adult male albino rats were divided into four equal groups: the control group, the N sativa oil-treated group (2.5 ml/kg), the Fosamax-treated group (0.05mg/kg), and both Fosamax and N sativa oil-treated group. Treatments were given orally once weekly for 13 weeks. Specimens from the duodenum were processed for light microscopy. Immunohistochemical study was carried out using antibodies against nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2), B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and Ki67 protein. Results: Specimens from Fosamax-treated rats showed a statistically significant decrease in the duodenal mucosal thickness. The lining epithelium showed nuclear alteration and vacuolated cytoplasm and there was mononuclear cellular infiltration. The immunohistochemical study of Fosamax-treated group showed a significant increase in NF-kB, COX-2 and Bax immunoreaction and a significant decrease in Bcl-2 and Ki67 expression. In contrast, minimal changes were observed in rats treated concomitantly with both Fosamax and N sativa oil with non-significant changes in the immunoreactions compared with the control group. Conclusion: Fosamax induced structural changes in the duodenal mucosa of adult albino rats, which could be ameliorated by concomitant treatment with nigella sativa oil.

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“…Nigella sativa offers protection against paracetamol-induced liver damage and nephrotoxicity [22] and has effects on hepatotoxicity and oxidative stress caused by acetaminophen. The findings of these studies indicate that thymoquinone, an antioxidant that also increases the activity of other antioxidants like glutathione, catalase, and superoxide dismutase, is responsible for the hepatoprotective effects of Nigella sativa.…”

Section: Paracetamol-induced Hepatotoxicitymentioning

confidence: 99%

Nigella sativa: A Potential Natural Antidote for Poisoning Cases

Patel,

Shaikh,

Patil

et al. 2023

Iect 2023

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Protective effect of Nigella sativa against paracetamol induced hepatic and renal damages

Cited by 5 publications

References 34 publications

Doxorubicin Induced Histomorphometric Changes in the Kidney of Albino Rats and Protective Role of Nigella Sativa

Doxorubicin Induced Histomorphometric Changes in the Kidney of Albino Rats and Protective Role of Nigella Sativa

Effect of Fosamax on the duodenal mucosa in adult male albino rats and the possible protection by nigella sativa oil: a histological and immunohistochemical study

Nigella sativa: A Potential Natural Antidote for Poisoning Cases

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