This study aims to increase the nutritional awareness of Saudi society and beneficial of the importance of the prickly pear through an electronic questionnaire that includes the extent of Saudi society's awareness of prickly pear and the percentage with diabetes. The results showed that the percentage of diabetes in Saudi society is high. In addition, the percentage that was aware of the relationship of prickly pear with diabetes was high. This is a good indication of Saudi society's awareness of the importance of prickly pear to lower blood sugar. Therefore, it was confirmed by conducting a determination of the nutritional values, total phenolic content, and flavonoids compounds, in addition, biological experiment on rats with high blood sugar, lipids, and cholesterol. The results indicated that the prickly pear the highest in total carbohydrate was 91.04%, meanwhile, the total fats, ash content, and crude fiber were lowering. Mineral content noticed that the potassium, magnesium, calcium, and phosphorus were higher contained amounts in prickly pear. The highest amounts of the prickly pear extract as total phenolic and flavonoids content, in addition, antioxidants capacity. The results after four weeks from biological experiment demonstrated that the prickly pear extract when taken orally at 400 ppm/day/kg body weight, it had contained the natural antioxidant, which important role in contributing to the health benefit of lowering glucose and reducing the lipid profiles. It could be recommended to increase nutrition awareness and health awareness of the importance of prickly pears and their effect on blood sugar levels.