Protective effect of oral contraceptive against <i>Helicobacter pylori</i> infection in US adult females: NHANES 1999–2000

Fong, Pedro; Wang, Q. T.

doi:10.1017/s0950268821000923

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…We believe that the high level of H. pylori infection in the present study population may be related to living in heavy metal-polluted areas. Studies have reported that the BCd and BPb levels, and in particular the Pb levels, were significantly associated with H. pylori seroprevalence among participants under 13 years of age and American adult women [3,32]. Moreover, as indicated by another study, even a small increase in the BPb levels may increase the risk of H. pylori infection [33].…”

Section: Discussionmentioning

confidence: 89%

Association among Helicobacter pylori Infection, Tooth Loss, and Heavy Medal Exposure in a Chinese Rural Population

Yan

Zhang

et al. 2022

IJERPH

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Previous research suggests that heavy metals may be associated with increased susceptibility to Helicobacter pylori infection. This study investigated the effect of heavy metal exposure (Pb and Cd) on tooth loss and H. pylori infection in a Chinese rural population, who live near a mining and smelting area. Blood samples were collected from the study participants to estimate the lead (Pb) and cadmium (Cd) exposure levels. H. pylori infection was analyzed using the 14C-urea breath test, and the number of missing teeth (MT), filled teeth (FT), and missing or filled teeth (MFT) were counted by conducting a physical examination. Regression analysis was used to assess the difference between H. pylori-positive and -negative individuals in the MT, FT, and MFT groups, adjusting for confounders. The H. pylori infection prevalence was higher in individuals in the high Cd or high Pb groups than that in the low Cd or low Pb groups (p < 0.05). In addition, greater numbers of FT and MFT were observed in individuals in the high Pb group than those in the low Pb group (p < 0.05). We further found 8.7% (95% CI, 2.8–23.8%, p = 0.017) of the effect of the high BPb level on H. pylori infection risk could be statistically explained by FT using amediation analyses in adjusted models, and 6.8% (95% CI, 1.6–24.8%, p = 0.066) by MFT. Furthermore, FT and MFT were significantly associated with increased risk for H. pylori infection (odds ratio (OR) = 4.938, 95% confidence interval (CI): 1.125–21.671; OR = 3.602, 95% CI: 1.218–10.648, respectively). Pb and Cd exposure may be associated with tooth loss and increased susceptibility to H. pylori infection, and tooth loss may be an independent risk factor for H. pylori infection.

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Section: Discussionmentioning

confidence: 89%

Association among Helicobacter pylori Infection, Tooth Loss, and Heavy Medal Exposure in a Chinese Rural Population

Yan

Zhang

et al. 2022

IJERPH

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“…Maybe sex hormones were responsible for age-specific differences. Some researches had demonstrated the protective effect of certain steroids against H. pylori infection ( Hosoda et al., 2011 ; Ohtani et al., 2011 ; Fong and Wang, 2021 ). For example, Kouichi Hosoda discovered that the growth of H. pylori could be inhibited by estradiol and progesterone.…”

Section: Discussionmentioning

confidence: 99%

“…In a study conducted by P Fong, the protective effect of oral contraceptives against H. pylori infection was investigated. The results indicated that women who were using oral contraceptives had a significantly reduced risk of acquiring H. pylori infection in comparison to those who did not use them ( Fong and Wang, 2021 ). As women reach the age of 40, their levels of free estradiol decline significantly, which weakens the protective effect of hormones on them ( Runolfsdottir et al., 2015 ).This may lead to a more vulnerable state in older women, resulting in greater muscle decline following H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

The impact of Helicobacter pylori infection on low skeletal muscle mass risk in Chinese women over 40: a cross-sectional analysis

Xu,

Qian,

Jin

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundSarcopenia can lead to significant personal, social, and economic burdens. The diagnosis of sarcopenia heavily relies on the identification of Low Skeletal Muscle Mass (LSMM), which is an independent predictor of frailty, disability, and increased risk of death among seniors. Women have physiologically lower levels of skeletal muscle mass than men, and female sarcopenia appears to be more influenced by menopause. They also tend to have higher body fat levels than man, which increases the risk of sarcopenia obesity. On another front, it’s also recognized that humans are largely prone to Helicobacter pylori (H. pylori) infection, with global prevalence rates often surpassing 50%. Nevertheless, the interconnection between H. pylori infection and LSMM remains relatively unexplored. Hence, our study specifically targeted women as the research population and sought to explore several risk factors for LSMM. Additionally, we delved into the potential correlation between LSMM and H. pylori infection in women, hoping to gain insights into potential preventative measures or treatment options that may enhance the quality of life for women affected by sarcopenia.MethodsWe conducted a cross-sectional study among women aged over 18 years undergoing physical examination. We performed 13C-urea breath test (UBT) for diagnosis of H. pylori infection and Bioelectrical impedance analysis (BIA) for the assessment of LSMM. Logistic regression models were used to analyze the associations of H. pylori infection with LSMM.ResultsThis study enrolled 1984 Chinese women who were undergoing health check-ups. A univariate logistic regression analysis did not reveal a direct correlation between H. pylori infection and LSMM among this female population (OR=1.149, 95% CI 0.904-1.459, p=0.257). Yet, upon dividing the participants into age-based subgroups, an evident link was observed between H. pylori infection and LSMM in women aged 40 or above (OR=1.381, 95%CI 1.032-1.848, p= 0.030). After adjusting for variables including Age, BMI, TP, ALK, Cre, this relationship remained statistically relevant (OR=1.514, 95%CI 1.085-2.113, p= 0.015).ConclusionsWomen who are over 40 years old and currently infected with H. pylori have an increased risk of developing LSMM. Therefore, timely treatment for H. pylori eradication is recommended for this group of women to reduce the occurrence of LSMM.

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“…In addition to estrogen, another steroid hormone, progestogen, was also found to exert bacteriolytic effects against H. pylori , stronger than those exhibited by estrogen[ 52 ]. In another study, Fong et al revealed the potential protective effect of oral contraceptives against H. pylori infection using the US National Health and Nutrition Examination Survey dataset[ 53 ]. A recent study found that the nuclear receptor estrogen-related receptor gamma (ESRRG) can affect H. pylori infection-driven gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Coptis, Pinellia, and Scutellaria as a promising new drug combination for treatment of Helicobacter pylori infection

Zhang¹,

Sheng²,

Yin³

et al. 2022

World J Clin Cases

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BACKGROUND Helicobacter pylori ( H. pylori ) is the most important infectious agent and plays an important role in the progression of chronic gastritis and the development of gastric cancer. AIM To identify efficient therapeutic agents or strategies that can treat H. pylori infection. METHODS We performed literature analysis, experimental validation, and network pharmacology. First, traditional Chinese medicine (TCM) prescriptions for the treatment of H. pylori infection were obtained from the China National Knowledge Infrastructure, China Biology Medicine, China Science and Technology Journal Database, and WanFang databases. In addition, we conducted a relevant search by Reference Citation Analysis ( RCA ) ( ). Next, we used TCM Inheritance Support System V2.5 to identify core drug combinations in the TCM prescriptions. Then, an H. pylori -associated chronic mouse model of gastritis was established. The antibacterial properties and anti-inflammatory potential of the core drug combination were evaluated by the rapid urease test, modified Warthin-Starry silver staining, histopathological analysis, and enzyme linked immunosorbent assay. Finally, the active compounds, hub targets, and potential signaling pathways associated with the core drug combination were analyzed by network pharmacology. RESULTS The TCM treatment of H. pylori was mainly based on reinforcing the healthy Qi and eliminating pathogenic factors by simultaneously applying pungent dispersing, bitter descending, cold and warm drugs. The combination of Coptis , Pinellia, and Scutellaria (CPS) was identified as the core drug combination from 207 prescriptions and 168 herbs. This drug combination eradicated H. pylori , alleviated the gastric pathology induced by H. pylori infection, and reduced the expression levels of tumor necrosis factor-α ( P = 0.024) and interleukin-1β ( P = 0.001). Moreover, a total of 35 compounds and 2807 targets of CPS were identified using online databases. Nine key compounds (tenaxin I, neobaicalein, norwogonin, skullcapflavone II, baicalein, 5,8,2'-trihydroxy-7-methoxyflavone, acacetin, panicolin, and wogonin) and nine hub target proteins (EGFR, PTGS2, STAT3, MAPK3, MAPK8, HSP90AA1, MAPK1, MMP9, and MTOR) were further explored. Seventy-seven signaling pathways were correlated with H. pylori -induced inflammation and carcinogenesis. CONCLUSION In summary, we showed that CPS is the core drug combination for treating H. pylori infection. Animal experiments demonstrated that...

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Protective effect of oral contraceptive against Helicobacter pylori infection in US adult females: NHANES 1999–2000

Cited by 7 publications

References 32 publications

Association among Helicobacter pylori Infection, Tooth Loss, and Heavy Medal Exposure in a Chinese Rural Population

Association among Helicobacter pylori Infection, Tooth Loss, and Heavy Medal Exposure in a Chinese Rural Population

The impact of Helicobacter pylori infection on low skeletal muscle mass risk in Chinese women over 40: a cross-sectional analysis

Coptis, Pinellia, and Scutellaria as a promising new drug combination for treatment of Helicobacter pylori infection

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