Protective Effect of Pepto-Bismol Liquid on the Gastric Mucosa of Rats

Goldenberg, Marvin M.; Honkomp, Leroy J.; Burrous, S. E.; Castellion, Alan W.

doi:10.1016/s0016-5085(19)32456-4

Cited by 33 publications

(8 citation statements)

References 1 publication

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“…The beneficial effect of BSS in childhood diarrhea of diverse etiologies has been demonstrated, and BSS was found to effectively eradicate enterotoxigenic E. coli and other enteropathogens from the stools of the infected children [42]. Moreover, the beneficial effect of BSS in a hamster model of C. difficile colitis has also been reported recently [46], and BSS has marked in Figure 10.5 Electron micrograph of H. pylori obtained from stomach biopsy 30 min after oral treatment of patient with bismuth medication.…”

Section: Bismuth Subsalicylate (Bss)mentioning

confidence: 84%

“…In vitro bactericidal activity of BSS against enterotoxigenic E. coil and other enteropathogens has been demonstrated by several investigators [36,42]. The beneficial effect of BSS in childhood diarrhea of diverse etiologies has been demonstrated, and BSS was found to effectively eradicate enterotoxigenic E. coli and other enteropathogens from the stools of the infected children [42].…”

Section: Bismuth Subsalicylate (Bss)mentioning

confidence: 99%

“…In 1976, in a placebo controlled study, Goldenberg et al demonstrated that BSS had antiemetic properties in dogs, and was an antinauseant and antiemetic in humans [41]. Previously, they had also demonstrated that Pepto-Bismol prevented alcohol, aspirin and cold restraint stress related gastric erosions in rats [42].…”

Section: Bismuth Subsalicylate (Bss)mentioning

confidence: 99%

See 2 more Smart Citations

Helicobacter Pyloriand Bismuth

Mendis¹,

Marshall

2010

Biological Chemistry of Arsenic, Antimony and Bismuth

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Section: Bismuth Subsalicylate (Bss)mentioning

confidence: 84%

Section: Bismuth Subsalicylate (Bss)mentioning

confidence: 99%

See 1 more Smart Citation

Helicobacter Pyloriand Bismuth

Mendis¹,

Marshall

2010

Biological Chemistry of Arsenic, Antimony and Bismuth

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“…The method described by Niiho et al [13] and Goldenberg et al [20] was employed. Male Sprague-Dawley strain rats were fasted for 24 h prior to the experiments but were allowed water ad libitum.…”

Section: Ethanol-induced Gastritismentioning

confidence: 99%

Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats

Niiho¹,

Yamazaki²,

Nakajima³

et al. 2005

J Nat Med

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Gentianae Radix, the dried root and rhizoma of Gentiana lutea L. (Gentianaceae), has long been used as a remedy for liver and stomach inflammation, eye troubles, etc. In this paper, the gastroprotective effects of the methanol extract of Gentian root (GM) were studied using different gastric lesion models. In pylorus-ligated rats, administration of GM in the duodenum suppressed gastric juice secretion and total acid output in a dosedependent manner. Oral or duodenum administration of GM showed significant protection against acute gastric ulcer induced by aspirin plus pylorus ligation, waterimmersion restraint stress-induced ulcers, and gastric mucosal injury induced by ethanol. Furthermore, four secoiridoid glycosides, amarogentin (A1), gentiopicroside (A2), amaroswerin (A3), and swertiamarin (A4), were obtained from Gentian root or Swertia herb, and their protective effects against stress-induced ulcers and ethanol-induced gastric mucosal injury were evaluated. The doses required for 50% inhibition (ID 50 ) of A1, A3, and A4 on stress-induced ulcers were calculated to be 5.76, 2.58, and 167 mg/kg respectively. The protective effect of A2 at 250 mg/kg was 26.5%. On ethanol-induced gastritis, 5.0 mg/kg of A1 and A3 showed remarkable suppressive effects (33.7 and 45.4%, respectively), and 20 mg/kg of A4 exhibited a suppressive effect (30.8%). The effects of A1, A3, and A4 on ethanol-induced gastric lesions were canceled by 5.0 mg/ kg indomethacin pretreatment. These results suggest that the therapeutic effects of Gentian root on gastric lesions are associated with enhanced mucosal defensive factors via the prostaglandin pathway in the cell membrane, and that secoiridoid glycosides contribute to this activity.

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“…Eine Stunde spater wurden 3,5 ml 500loiges Athanol durch eine Schlundsonde intragastral verabreicht. 210 Minuten nach der Athanol-Gabe wurden die Tiere mittels CO, getotet [9].…”

Section: Ifthanof-ulkusmodellunclassified

Pharmakologische Untersuchungen von Kamillen–Inhaltsstoffen – III. Tierexperimentelle Untersuchungen über die ulkusprotektive Wirkung der Kamille

Szelényi¹,

Isaac²,

Thiemer³

1979

Planta Med

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intensiver Forschung no& nicht restlos Bisabolol, a component of chamomile (Matricaria chamomilla) was studied in different experimental ulcer models. Bisabolol inhibited the occurence of ulceration induced by indometacine, stress o r ethanol. The time of healing of ulcers induced by chemical stress (acetic acid) or by heat-coagulation was shortened by Bisabolol. The chamomile extract K A M I L L O S A N~~ also inhibited the occurence of the ethanol-induced ulceration. Einleitung Ursache und Pathogenese des gastralen bzw. duodenalen Ulkus sind trotz Hersteller: Chemiewerk Homburg, Zweigniederlassung der Degussa, FrankfurtIMain. Adresse: Dr. 0. Isaac, Daimlerstrajle 25, 0-6000 FrankfrcrtlMain 1 Heruntergeladen von: University of Pennsylvania Libraries. Urheberrechtlich geschützt.

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Protective Effect of Pepto-Bismol Liquid on the Gastric Mucosa of Rats

Cited by 33 publications

References 1 publication

Helicobacter Pyloriand Bismuth

Helicobacter Pyloriand Bismuth

Gastroprotective effects of bitter principles isolated from Gentian root and Swertia herb on experimentally-induced gastric lesions in rats

Pharmakologische Untersuchungen von Kamillen–Inhaltsstoffen – III. Tierexperimentelle Untersuchungen über die ulkusprotektive Wirkung der Kamille

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