Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H2O2-Induced Cellular Senescence

Lee, Young A; Cho, Eun Ju; Yokozawa, Takako

doi:10.1248/bpb.31.1265

Cited by 68 publications

(52 citation statements)

References 40 publications

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“…32 Recently, microRNAs, such as let-7 members, have been shown to have a role in newt lens regeneration. 33,34 MiR-34a participates in the aging process by suppression of SirT1 expression.…”

Section: Eyementioning

confidence: 99%

Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts

Chien

Chen

Liu

et al. 2013

Eye

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Purpose MicroRNA 34a (miR-34a) is involved in regulating tissue senescence. However, the role of miR-34a in age-related cataracts is unclear. In this study, we evaluated the correlations among the severity of lens opacity, patient age, and miR-34a expression level in the lens epithelium of age-related cataracts for clarifying the role of miR-34a in the lens senescence. Methods This study was carried as a case control study in the Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan. We recorded age of each patient at the time of their cataract surgery and information regarding lens opacity according to a modified version of the Lens Opacities Classification System III. Correlations among age, lens opacity, and miR-34a expression levels were evaluated. Results This study evaluated 110 patients with a mean age of 73.19 years (SD±10.2). Older patients had higher nuclear cataract (NC), cortical (C), and posterior subcapsular cataract (P) scores (one-way analysis of variance (ANOVA), Po0.05). miR-34a expression levels were significantly different between each age group (ANOVA post hoc Bonferroni's test, Po0.001), and there were moderate correlations between high NC, C, and P cataract scores and high miR-34a levels (Pearson correlation coefficient; R ¼ 0.606, 0.575, and 0.515, respectively). Conclusions The current study demonstrated positive correlations between high miR-34a levels and high lens opacity severity in NC, C, or P cataracts. These results suggest that miR34a expression has a role in lens senescence.

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Section: Eyementioning

confidence: 99%

Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts

Chien

Chen

Liu

et al. 2013

Eye

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“…The radical scavenging activity of the Diospyros by employing the DPPH radical scavenging method was also analyzed. Although there are some reports regarding antioxidant activity of fruits and peels of persimmon (Jung, et al, 2005;Lee, et al, 2008;Fukai, et al, 2009), no work has been done on the comparative research about chemical profile, bioactive compounds content and antioxidant capacity of Portuguese Diospyros kaki and their relation with geographic regions.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of Portuguese Diospyrus Kaki Fruit by Geographical Origins

Vinha

Soares

Herdeiro

et al. 2012

JAS

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Lately, several studies have demonstrated the health benefits associated with natural compounds consumption. Fruit phenolics, lycopene and ascorbic acid, have strong antioxidant, anti-inflammatory, antimugenic and anticarcinogenic activities. In the present study parameters related to fruit quality and climacteric conditions, such as color, moisture, pH, water activity, total phenolic compounds, ascorbic acid and lycopene content were analyzed. Diospyros kaki cv. chocolate fruits were extracted with different solvents, such as methanol, ethanol and water. Total polyphenolics of each extract determined by Folin-Ciocalteu method were found to be higher in methanolic extract (106.2 mg/100g sample) and lower in ethanol (21.9 mg/100g sample) considering Diospyros fruits with peel. The antioxidant activity (AA) was evaluated by an in vitro model system trough 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity (DPPH • ) assay. Significant variations were found in the levels of these parameters according to different geographic regions. It was possible to describe correlations between the antioxidant compounds (polyphenolics, ascorbic acid and lycopene) and the antioxidant activity. Aqueous solvent was more effective on the extraction of antioxidant compounds from Portuguese Diospyros fruits with 52% radical scavenging activity. Results support the importance of Diospyros kaki cv. chocolate fruits, Portuguese cultivar, as a functional food with high antioxidant potential that may have beneficial effects against oxidative human damage.

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“…Though the various parts of persimmon are used as medicine, persimmon peel is usually discarded. Recently, persimmon peel has been reported to includes higher concentration of carotenoids and polyphenols than fruit 7) , and persimmon peel extract is effective for reducing oxidative stress, DNA and cellular oxidative damage [8][9][10] . Oxidation of DNA and cell are involved in free radical and active oxygen, and they are the factors to cause various illness.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Activity of Compounds Extracted from Persimmon Peel (Diospyros kaki THUNB.)

Fukai¹,

Tanimoto²,

Maeda³

et al. 2009

J. Oleo Sci.

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Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H2O2-Induced Cellular Senescence

Cited by 68 publications

References 40 publications

Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts

Correlation between microRNA-34a levels and lens opacity severity in age-related cataracts

Chemical Composition and Antioxidant Activity of Portuguese Diospyrus Kaki Fruit by Geographical Origins

Pharmacological Activity of Compounds Extracted from Persimmon Peel (Diospyros kaki THUNB.)

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