Protective Effect of Phenolic Extract of <i>Urtica dioica</i> leaves against Carbon Tetra-Chloride Induced Hepatotoxicity in Male Rats

Jawad, Murtadha M.; Homady, Merza H.; Aldujaili, A. N.

doi:10.5958/0974-360x.2017.00465.6

Cited by 6 publications

(2 citation statements)

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“…Thus, the intake of antioxidants and other natural products as protective measures is being proposed. The studies on hepatoprotective experiential models have noted that CCl 4 intercede hepatotoxicity fundamentally acts on liver out of free radicalmediated practicability (Achuthan et al, 2003 andJawad et al, 2017). Lately, precedent drugs have been used to treat chronic liver troubles, these drugs have often much side effects (Mahmoud et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)

Osman

Toliba

2019

Egypt. J. Food Sci.

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I N this study the hepatoprotective activity of the crude phenolic rich extract (CPRE) isolated from oyster mushrooms on carbon tetrachloride (CCl 4)-induced oxidative stress was investigated in albino rats. The hepatoprotective activity was examined through various biochemical parameters. Administration of CCl 4 for 28 days exhibited a significant increase (P<0.05) in serum markers of liver damage, i.e., alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, urea, creatinine, total lipids and triglycerides. Whereas, the serum markers were significantly decreased (P<0.05) by CPRE administration. CCl 4 exposure significantly decreased (P<0.05) the hepatic antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. Contrarily, the CPRE treatments showed significant increases (P<0.05) in these hepatic activities. The results obtained from this study clearly validated the potential antioxidant activity of CPRE isolated from oyster mushrooms against several oxidation systems in-vivo, which contributed to its hepatoprotective effects in CCl 4-induced liver injury in male albino rats. Finally, oyster mushrooms could be added as an additional nutrient to food products as it constitutes a new potential source of natural antioxidant and antibacterial agents.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)

Osman

Toliba

2019

Egypt. J. Food Sci.

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“…The evaluation of ST-segment elevation resolution through ECG is a valuable method for estimating coronary microvascular dysfunction and obstruction in a non-invasive manner. Research has demonstrated that incomplete resolution of ST-segment elevation is linked to microvascular dysfunction, larger infarct size, and inferior clinical outcomes when compared to complete ST-segment elevation resolution [18,19].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil gelatinase-associated lipocalin (NGAL) circulating levels are related to LDL Myocardial infarction

Alhamed,

Saqban,

Al-dujaili

2024

BIO Web Conf.

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Background: Low-density lipoprotein receptors (LDL-R) in hepatocytes are degraded by the enzyme Neiutrophophil gielatinase-associated lipocalin (NGAL) A brand-new target for lipid-lowering treatment is Neiutrophophil gielatinase-associated lipocalin (NGAL) inhibition. Three subsets of monocytes, which play a critical role in the pathophysiology of atherosclerosis, are known. Objectives: The aim of this study was to examine whether circulating levels of Neiutrophophil gielatinase-associated lipocalin (NGAL) are associated with LDL liped subsets. Materials and Methods: We included 70 patients with coronary artery disease. Neiutrophophil gielatinase-associated lipocalin (NGAL) levels were measured and LDL liped and 30 control health. Results: Eighty percent of the patients were men, with a mean age between 40 and 70. Patients increese displayed greater Neiutrophophil gielatinase-associated lipocalin (NGAL) -levels compared to the 30 male control group. Neiutrophophil gielatinase-associated lipocalin (NGAL) levels in the blood were associated with CM treatment in patients, whereas NCM had the opposite effect. Patients whose levels of Neiutrophophil gielatinase-associated lipocalin (NGAL) were greater than the median displayed a significantly higher. Conclusions: Endurance training, resistance training, and combined training improve cardiovascular risk factors associated with obesity. These types of training methods also improve cardiovascular risk factors in school obese children. Also, they can be used as effective exercise programs for these people. Therefore, EET, RET, and CET used in this study, especially EET, can be recommended as a non-medical way to improve the incidence of cardiovascular risk factors and obesity-related disorders in obese boys.

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Study of the effect of the phenolic extract of the Urtica dioica the level of Des-gamma-prothrombin after treatment with carbon tetrachloride

Jawad

Aldujaili

2019

J. Phys.: Conf. Ser.

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The present study was conducted on 90 males of Wistar rat weightings (190-300 g), aged (15-17) weeks, at the animal house faculty of science / university of Kufa during the period from December 2016 to July 2017. This study included some physiological to evaluate the protective role of phenolic extract of Urtica dioica leaves (250 and 500 mg/kg ) against hepatotoxicity induced by carbon tetrachloride. The animals experimetal are divided into 22 groups (n=5 rats per each group) for duration of two and three months. The results showed a significant increase (P⩽0.05) in serum levels of biomarker proteins (Des gamma carboxy prothrombin) in carbon tetrachloride groups as compared with the control group. A significant decrease (P⩽0.05) in the serum levels of biomarker proteins (Des gamma carboxy prothrombin) in groups treated with phenolic extract of Urtica dioica as compared with carbon tetrachloride group. The present study concluded that phenolic extract of Urtica dioica leaves had a protective effect on hepatotoxicity in carbon tetrachloride induced group.

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Protective Effect of Phenolic Extract of Urtica dioica leaves against Carbon Tetra-Chloride Induced Hepatotoxicity in Male Rats

Cited by 6 publications

References 0 publications

Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)

Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)

Neutrophil gelatinase-associated lipocalin (NGAL) circulating levels are related to LDL Myocardial infarction

Study of the effect of the phenolic extract of the Urtica dioica the level of Des-gamma-prothrombin after treatment with carbon tetrachloride

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