Protective effect of polaprezinc on cadmium-induced injury of lung epithelium

Kimura, Kazuma; Nakano, Yukari; Sugizaki, Taichi; Shimoda, Mikako; Kobayashi, Nahoko; Kawahara, Masahiro; Tanaka, Ken Ichiro

doi:10.1039/c9mt00060g

Cited by 15 publications

(12 citation statements)

References 43 publications

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“…Polaprezinc is a chelated form of zinc and L -carnosine that shows therapeutic activity for the treatment of pressure ulcers and other intestinal lesions [ 61 , 62 ], is used in cancer chemotherapy [ 63 , 64 ], presents therapeutic effects on cardiac function [ 65 ] and has a protective effect against respiratory diseases [ 66 ].…”

Section: Resultsmentioning

confidence: 99%

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment

et al. 2022

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Background Components of the antioxidant defense system in Trypanosoma cruzi are potential targets for new drug development. Superoxide dismutases (SODs) constitute key components of antioxidant defense systems, removing excess superoxide anions by converting them into oxygen and hydrogen peroxide. The main goal of the present study was to investigate the genes coding for iron superoxide dismutase (FeSOD) in T. cruzi strains from an evolutionary perspective. Methods In this study, molecular biology methods and phylogenetic studies were combined with drug assays. The FeSOD-A and FeSOD-B genes of 35 T. cruzi strains, belonging to six discrete typing units (Tcl–TcVI), from different hosts and geographical regions were amplified by PCR and sequenced using the Sanger method. Evolutionary trees were reconstructed based on Bayesian inference and maximum likelihood methods. Drugs that potentially interacted with T. cruzi FeSODs were identified and tested against the parasites. Results Our results suggest that T. cruzi FeSOD types are members of distinct families. Gene copies of FeSOD-A (n = 2), FeSOD-B (n = 4) and FeSOD-C (n = 4) were identified in the genome of the T. cruzi reference clone CL Brener. Phylogenetic inference supported the presence of two functional variants of each FeSOD type across the T. cruzi strains. Phylogenetic trees revealed a monophyletic group of FeSOD genes of T. cruzi TcIV strains in both distinct genes. Altogether, our results support the hypothesis that gene duplication followed by divergence shaped the evolution of T. cruzi FeSODs. Two drugs, mangafodipir and polaprezinc, that potentially interact with T. cruzi FeSODs were identified and tested in vitro against amastigotes and trypomastigotes: mangafodipir had a low trypanocidal effect and polaprezinc was inactive. Conclusions Our study contributes to a better understanding of the molecular biodiversity of T. cruzi FeSODs. Herein we provide a successful approach to the study of gene/protein families as potential drug targets. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment

et al. 2022

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“…В проведённом ранее исследовании [3] описано воздействие токсичных факторов пожара на лёгочную ткань, приводящее к снижению функции лёгких, развитию гиперчувствительности лёгочной ткани и появлению различных симптомов респираторных заболеваний. Исследования по оценке состояния здоровья лиц, участвующих в пожаротушении [2][3][4][5], показали, что болезни органов дыхания занимают одно из главных мест в структуре общей заболеваемости пожарных, а стаж работы по специальности коррелировал с ухудшением функции дыхания и увеличением рисков респираторных заболеваний уже через 4 года. Одним из компонентов продуктов горения, с которыми встречаются пожарные в процессе своей деятельности, являются соединения токсичных металлов, к числу которых относятся мышьяк, кадмий, никель, свинец.…”

Section: экология человека | Ekologiya Cheloveka (Human Ecology)unclassified

“…Одним из компонентов продуктов горения, с которыми встречаются пожарные в процессе своей деятельности, являются соединения токсичных металлов, к числу которых относятся мышьяк, кадмий, никель, свинец. В организме человека эти микроэлементы могут способствовать усилению окислительного стресса, нарушению барьерных механизмов, что приводит к воспалению и нарушению функции тканей легких [2,5] и проявляется клинически в виде обструктивной болезни лёгких и фиброза. В единичных исследованиях установлена взаимосвязь между увеличением концентрации кадмия, свинца в различных биологических средах и прогрессирующим ухудшением функции лёгких [5].…”

Section: экология человека | Ekologiya Cheloveka (Human Ecology)unclassified

Relationship of bioelemental status and changes in the functional state of the lungs in EMERCOM firefighters of Russia

Vlasenko

Sannikov

Yakovleva

et al. 2023

Ekologiya cheloveka (Human Ecology)

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Background: Firefighters are characterized by constant interaction with smoke and various combustion products, which, entering the body can, affect the state of the respiratory system. Objective: To study the relationship of the bioelemental status with changes in the functional state of the lungs in firefighters of the Ministry of Emergency Situations of Russia. Results: The study revealed an increase in a number of toxic microelements in firefighters by 2-5 times compared with persons not participating in fire extinguishing, as well as a decrease in the content of essential microelements in the studied hair samples. The connection of toxic trace elements (aluminum, silver, cadmium) with a decrease in the diffusion capacity of the lungs, broncho-obstructive changes and pulmonary fibrosis was shown. The study showed the relationship between the accumulation of the level of silver, aluminum and cadmium with noticeable changes in the functional state of the lungs.

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“…Treatment of chronic obstructive pulmonary disease. Kimura et al (52) used the human cancer lung epithelial cell line A549 to evaluate the effect of polaprezinc on cadmium-induced apoptosis. Polaprezinc was found to inhibit CdCl 2 -induced apoptosis of human lung epithelial cells.…”

Section: Other Clinical Applicationsmentioning

confidence: 99%

Recent advances on polaprezinc for medical use (Review)

Sun

Zhang

2021

Exp Ther Med

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The present study described the chemical and biological properties of zinc complex of L-carnosine (L-CAZ; generic name, polaprezinc; chemical name, catena-molecular formula, C 9 H 14 N 4 O 3 Zn; molecular weight, 291.6404; CAS registry number, 107667-60-7). Characterized as a white or yellowish white crystalline powder, this drug is insoluble in glacial acetic acid and almost insoluble in water, methanol, ethanol and ether. It is soluble in dilute hydrochloric acid, dilute nitric acid and sodium hydroxide solution, and its melting point is 260-270˚C. Polaprezinc is an anti-ulcer drug that was jointly studied and developed by Hamari Chemicals Co., Ltd. and Zeria Pharmaceutical Co., Ltd., and was first approved in Japan in 1994. This review article summarizes the research advances of polaprezinc, including the patents, preparations, synthetic routes, pharmacokinetics, pharmacological effects and application in clinical research. Contents 1. Introduction 2. Patents and preparations 3. Synthetic route and pharmacokinetics of polaprezinc 4. Pharmacological study of polaprezinc 5. Clinical uses of polaprezinc 6. Other clinical applications 7. Safety 8. Conclusion

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Protective effect of polaprezinc on cadmium-induced injury of lung epithelium

Abstract: The induction of metallothioneins by polaprezinc contributes to its protective effect against cadmium-induced lung epithelial cell death.

Cited by 15 publications

References 43 publications

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment

Relationship of bioelemental status and changes in the functional state of the lungs in EMERCOM firefighters of Russia

Recent advances on polaprezinc for medical use (Review)

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