Protective effect of Polygonatum sibiricum against cadmium-induced testicular injury in mice through inhibiting oxidative stress and mitochondria-mediated apoptosis

Han, Chunyang; Zhu, Yun; Yang, Zhiming; Fu, Shiyan; Zhang, Wanjun; Liu, Cuiyan

doi:10.1016/j.jep.2020.113060

Cited by 46 publications

(28 citation statements)

References 26 publications

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“…In these studies in the literature list, we have learned that cadmium causes decreased levels of the indicator related to testicular oxidation in the testicular tissue. 4,5,[7][8][9] In our current study, in cadmium chloride group, SOD and GPx activity and GSH and testosterone levels were significantly lower than the control group. Our results support the previous studies.…”

Section: Discussioncontrasting

confidence: 37%

“…1 Cadmium, a heavy metal, has been reported to be abundant especially in industrial areas, 2 causing injury in the liver, kidneys and testicles. [3][4][5][6][7][8][9] Especially, in the toxicity it causes in the testicles, it has been reported that spermatogenesis is impaired and there are decreases in gonadotropic hormones and testosterone hormone. [10][11][12] It has also been reported to cause apoptosis in the male reproductive cell.…”

Section: Introductionmentioning

confidence: 99%

“…6 There are many studies in which oxidant / antioxidant balance is troubled after cadmium exposure. [3][4][5][6]8,9 Boron is an essential nutrient in animals as much as necessary for the normal growth and development of plants. 13,14 It is emphasized that some fruits (Banana, apple, grape, peanut, hazelnut) and vegetables (carrot, potato, bean, broccoli, cabbage) have rich boron content.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

Belhan¹,

Kömüroğlu²,

Özdek³

et al. 2021

IJPER

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Background: The present study aims to investigate the effects of calcium fructoborate on testicular DNA damage and testicular tissue biochemical markers and serum testosterone levels after cadmium chloride administration. Materials and Methods: 28 Wistar albino rats (200-220 g) in the study were divided into 4 groups with an equal number. These groups are; Control group (No chemicals applied), calcium fructoborate (100 mg) group, Cadmium chloride (200 mg/L) + calcium fructoborate (100 mg), Cadmium chloride (200 mg/L) group. The study lasted 28 days and both chemicals were applied daily with oral gavage. Results: While 8-hydroxy-2-deoxyguanosine (8-OHdG) expression was moderate in the cadmium chloride + calcium fructoborate group, the expression in the cadmium chloride group was severe. In the cadmium chloride group, testicular tissue glutathione (GSH) and 8-OHdG levels, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and serum testosterone levels were significantly decreased compared to other groups. It is determined that the reversal of the change in the parameters listed in the calcium fructoborate group. Conclusion: The reversal of the change in the parameters listed in the calcium fructoborate group indicates the positive strength of the present chemical. It is our suggestion to transfer calcium fructoborate into life practice by conducting further clinical studies and evaluating different parameters.

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Section: Discussioncontrasting

confidence: 37%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

Belhan¹,

Kömüroğlu²,

Özdek³

et al. 2021

IJPER

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“…It must be kept in mind that spermatozoa are extremely sensitive to ROS, owing to their high amount of polyunsaturated fatty acids and their low capacity to repair DNA [ 23 , 73 ]. As a result, a ROS increase is able to induce damage in the key enzymes involved in testicular steroidogenesis, with a reduction in testosterone levels [ 79 ], and in the process of spermatogenesis [ 80 ], with abnormal sperm morphology and decreased sperm number, finally inducing male infertility.…”

Section: Cadmium-induced Oxidative Stress Causes Testicular Injury An...mentioning

confidence: 99%

Nutraceuticals: A New Challenge against Cadmium-Induced Testicular Injury

et al. 2022

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Cadmium (Cd) is a widespread heavy metal and a ubiquitous environmental toxicant. For the general population, the principal causes of Cd exposure are cigarette smoking, air pollution and contaminated water and food consumption, whereas occupational exposure usually involves humans working in mines or manufacturing batteries and pigments that utilize Cd. The aim of the present review is to evaluate recent data regarding the mechanisms of Cd-induced testicular structural and functional damages and the state of the art of the therapeutic approaches. Additionally, as the current literature demonstrates convincing associations between diet, food components and men’s sexual health, a coherent nutraceutical supplementation may be a new valid therapeutic strategy for both the prevention and alleviation of Cd-induced testicular injury. The toxic effects on testes induced by Cd include many specific mechanisms, such as oxidative stress, inflammation and apoptosis. As no specific therapy for the prevention or treatment of the morbidity and mortality associated with Cd exposure is available, the development of new therapeutic agents is requested. Dietary strategies and the use of nutraceuticals, particularly abundant in fresh fruits, beans, vegetables and grains, typical of the Mediterranean diet, are recommended against Cd-induced testicular injury.

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“…In the clinic, Erjing pill is mainly used to protect the kidneys, delay aging and enhance immunity and memory (13) (15,16). Polygonatum sibiricum may be used to treat the reproductive system, regulate immunity and enhance brain function (17,18). Lycium chinense is used as an adjuvant therapy for various clinical diseases.…”

Section: Evidence-based Complementary and Alternative Medicine Bioinformatics Approach Through Network Pharmacology And Molecular Dockingmentioning

confidence: 99%

Evidence‑based complementary and alternative medicine bioinformatics approach through network pharmacology and molecular docking to determine the molecular mechanisms of Erjing pill in Alzheimer's disease

et al. 2021

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Erjing pill, a Traditional Chinese Medicine (TCM) formulation composed of Polygonatum sibiricum and Lycium chinense, has an important role in the treatment of Alzheimer's disease (AD). However, the underlying mechanisms of the action of Erjing pill in AD have remained elusive. In the present study, the key ingredients of Erjing pill were investigated and the active components and their mechanisms of action on AD were analyzed based on networks pharmacology. By using the TCM and TCM Systems Pharmacology and databases, the components of Erjing pill were screened and the data were captured using Discovery Studio. The SwissTarget webserver database was used to predict the potential protein targets of Erjing pill components for pathologies related to AD. The data were further analyzed with the disease targets of AD based on analysis of the Online Mendelian Inheritance in Man, DiGSeE and Therapeutic Target Database. Subsequent analysis of mechanistic pathways of the screened components and protein targets allowed us to construct a network by using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes, which revealed potential molecular mechanisms of Erjing pill against AD. Finally, the protective effect of three active components on neurons was verified using an in vitro injury model of PC12 cells induced by Aβ 25-35 . The results indicated that 65 bioactive components of Erjing pill, including lauric acid and zederone, and 6 targets, including acetylcholinesterase, butylcholinesterase and amyloid protein precursor, were closely associated with the prevention and treatment of AD. The molecular components of Erjing pill were indicated to be involved in various biological signaling processes, mainly in synaptic signal transmission, transsynaptic signal transmission and chemical synaptic transmission. Furthermore, related pathways targeted by Erjing pill in AD included the regulation of neuroactive ligand-receptor interactions, the PI3K-Akt signaling pathway, serotoninergic synapses, calcium signaling pathways and dopaminergic synapses. A cell viability assay indicated that the compounds (polygonatine A, polygonatine C and 4' ,5-dihydroxyflavone) assessed were able to significantly improve the survival rate and increase the Ca 2+ level in a PC12 cell model of AD induced by amyloid-β 25-35 . The present study revealed that the mechanisms of action of Erjing pill to prevent and treat AD included a multicompound, multitarget and multipathway regulatory network.

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Protective effect of Polygonatum sibiricum against cadmium-induced testicular injury in mice through inhibiting oxidative stress and mitochondria-mediated apoptosis

Cited by 46 publications

References 26 publications

Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

Investigation of the Effects of Calcium Fructoborate on Testicular Structure in Rats within the Framework of Biochemical Parameters, Testosterone Hormone and DNA Damage in Cadmium Chloride Induced Toxicity

Nutraceuticals: A New Challenge against Cadmium-Induced Testicular Injury

Evidence‑based complementary and alternative medicine bioinformatics approach through network pharmacology and molecular docking to determine the molecular mechanisms of Erjing pill in Alzheimer's disease

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