Protective effect of polysaccharide from Sophora japonica L. flower buds against UVB radiation in a human keratinocyte cell line (HaCaT cells)

Li, Liyan; Huang, Tao; Chong, Lan; Ding, Hui; ChunSheng, Yan; Dou, Yanli

doi:10.1016/j.jphotobiol.2018.12.001

Cited by 61 publications

(43 citation statements)

References 41 publications

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“…Finally, the role of Sophora japonica in Chinese Herbal Traditional Medicine is widely known, and numerous biological activities, such as antioxidant, anti-bacterial, anti-allergic, and anti-inflammatory, have been reported [31]. In addition, the photoprotective and anti-pollution effects of Sophora japonica have also been studied [32,66]. nitrosamine injuries and subsequent diseases [68][69][70][71].…”

Section: Discussionmentioning

confidence: 99%

“…Extracts and phenolic compounds derived from m any plants, such as blueberry, green tea, grape, pomegranate, different marine algae, have been proven to be effective in attenuated the cellular oxidative stress and the inflammation induced by different air pollutants [23][24][25][26][27][28]. Published studies have shown that extracts from Lippia citriodora leaf, Olea europaea leaf, Sophora japonica, and Rosmarinus officials, as well as its main bioactive phenolic compounds, are effective antioxidants with the ability to counteract different environmentally -induced skin damage [29][30][31][32][33][34][35][36][37][38][39]. Also, a preliminary study of a blend of these 4 herbal extracts standardized in verbascoside, oleuropein, hydroxytorosol, quercetin and rosemary diterpenes (carnosic acid and carnosol) demonstrated the photo-urban pollution protective efficacy in keratinocytes cell model and in living human skin explants.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Nobile¹,

Schiano²,

Peral³

et al. 2020

Preprint

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Repeated air pollution exposure is one of the major threats to skin health. Air pollution causes skin damage and accelerates skin ageing mainly through oxidative stress mechanisms. Since it is difficult to minimize skin exposure from air pollutants, especially in urban areas, strategies to protect the skin are needed. On the other hand, plant phenolic compounds have been found to be effective in attenuating cellular oxidative stress and inflammation induced by different air pollutants. Therefore, we conducted a 12-week randomized, placebo-controlled, double blind study to assess the efficacy of a polyphenol-enriched dietary supplement (comprised of olive leaf, lemon verbena, rosemary and Sophora japonica extracts) in reducing pollution-induced oxidative stress and in improving different skin parameters related to skin ageing of Caucasian and Asian volunteers living in a polluted urban European area (Milan). One hundred healthy women were recruited and randomized in the placebo or in the test dietary supplement treatment arms. To assess the efficacy of the dietary supplement, the total antioxidant capacity on saliva (FRAP) was determined, as well as the oxidative damage on skin (lipoperoxides content), the skin moisture (corneometry), the trans-epidermal water loss (Tewameter), the skin radiance and the skin colour, (spectrophotometry), the skin elasticity (cutometry), the skin sebum content (sebumeter), and the skin roughness (image analysis). As a result, both inter-group and intra-group analysis proved that the dietary supplement improved all clinical and biochemical monitored parameters, in both Caucasian and Asian individuals. In conclusion, the results of the study indicate a reduced oxidative stress-induced skin damage in both Asian and Caucasian women living in a polluted urban area.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Nobile¹,

Schiano²,

Peral³

et al. 2020

Preprint

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“…UVB radiation was harmful to skins which resulted in cellular damage, mutation, inflammation, photoaging, and consequently, photocarcinogenesis progression (Lan, 2019). Natural herbs were precious library for discovery of UV protective agents (Li et al, 2019;Mohan and Gupta, 2019). Kim et al found that Timo AIII, which isolated from Chinese herb A. asphodeloides Bunge, protected against UVB-induced cell migration and invasion in both human epidermal keratinocytes (HEKs) and dermal fibroblasts (HDF), and the underlying mechanism were involved in the inhibition of Akt/MAPK signaling pathway and down-regulation of MMP9 (Kim et al, 2019a).…”

Section: Anti-uvb Radiationmentioning

confidence: 99%

Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review

et al. 2020

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Anemarrhena asphodeloides Bunge is a famous Chinese Materia Medica and has been used in traditional Chinese medicine for more than two thousand years. Steroidal saponins are important active components isolated from A. asphodeloides Bunge. Among which, the accumulation of numerous experimental studies involved in Timosaponin AIII (Timo AIII) draws our attention in the recent decades. In this review, we searched all the scientific literatures using the key word "timosaponin AIII" in the PubMed database update to March 2020. We comprehensively summarized the pharmacological activity, pharmacokinetics, and toxicity of Timo AIII. We found that Timo AIII presents multiple-pharmacological activities, such as anti-cancer, antineuronal disorders, anti-inflammation, anti-coagulant, and so on. And the anti-cancer effect of Timo AIII in various cancers, especially hepatocellular cancer and breast cancer, is supposed as its most potential activity. The anti-inflammatory activity of Timo AIII is also beneficial to many diseases. Moreover, VEGFR, X-linked inhibitor of apoptosis protein (XIAP), B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1), thromboxane (Tx) A2 receptor, mTOR, NF-kB, COX-2, MMPs, acetylcholinesterase (AChE), and so on are identified as the crucial pharmacological targets of Timo AIII. Furthermore, the hepatotoxicity of Timo AIII was most concerned, and the pharmacokinetics and toxicity of Timo AIII need further studies in diverse animal models. In conclusion, Timo AIII is potent as a compound or leading compound for further drug development while still needs in-depth studies.

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“…La toxicidad de los extractos de Palmaria palmata y Porphyra sp. se monitorizó utilizando el ensayo MTT en queratinocitos humanos inmortalizados (HaCaT) siguiendo el protocolo de Li et al [31]. Las células, cultivadas en monocapa en un flask, fueron puestas en suspensión tras un tratamiento con tripsina comercial (10x, 1 mL, 10 min, 37 ºC) y diluidas en 4 mL de DMEM (High glucose, BioWest).…”

Section: Ensayos De Toxicidad Mtt-24h Con Células Humanas (Hacat)unclassified

“…En este sentido, la línea celular HaCaT (queratinocitos humanos inmortalizados) se ha utilizado ampliamente en ensayos de crecimiento y diferenciación celular [30], aunque se utilizan también para detectar actividad citotóxica y antitumoral en diversos compuestos y extractos. Concretamente, se ha utilizado tanto en ensayos de extractos de plantas [15,31,32] como de algas [33,34].…”

Section: Introductionunclassified

Determinación de la actividad tóxica de extractos optimizados de Palmaria y Porphyra para el tratamiento de la lesión por isquemia/reperfusión

Irisarri

Sanz

2020

Nereis

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La lesión por isquemia-reperfusión (I/R) puede provocar rechazos en los trasplantes de órganos debido al daño a nivel celular que producen los Radicales Libres de Oxígeno (ROS). Se ha comprobado que los antioxidantes naturales pueden reducir este daño. Los extractos de muchas algas poseen una actividad antioxidante notable, pero se necesita comprobar la toxicidad de estos antes de proponerlos como fármacos. En este estudio, se realizaron dos ensayos toxicológicos con queratinocitos humanos inmortalizados (HaCaT) y nauplios de Artemia salina para valorar la toxicidad de dos extractos con actividad antioxidante de Palmaria palmata y Porphyra sp. Se obtuvieron LC50 de 7,843% (v/v) de concentración de extracto en P. palmata en el ensayo con HaCaT y 3,2583% (v/v) en el ensayo con A. salina, mientras que con Porphyra sp. se obtuvo 10,7463% (v/v) en el ensayo con HaCaT y 6,5688% (v/v) en el ensayo con A. salina. Los Niveles Sin Efecto Adverso Observable (NOAEL) obtenidos para cada alga en cada ensayo mostraron significativamente una mayor toxicidad del extracto de P. palmata que del de Porphyra sp. (p < 0,05). Finalmente, se propuso un índice que tiene en cuenta la actividad antioxidante y la toxicidad de cada extracto para predecir su eficiencia in vivo, confirmando los resultados anteriores, y por ello se escogió el extracto de Porphyra sp. como el más idóneo para continuar con los ensayos preclínicos en el desarrollo de un fármaco para el tratamiento de la lesión por I/R.

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Protective effect of polysaccharide from Sophora japonica L. flower buds against UVB radiation in a human keratinocyte cell line (HaCaT cells)

Cited by 61 publications

References 41 publications

Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review

Determinación de la actividad tóxica de extractos optimizados de Palmaria y Porphyra para el tratamiento de la lesión por isquemia/reperfusión

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