Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats

Zhu, Ming‐Jun; CaiJiao, Wang; Husheng, Zhang; Pei, Xian-Wu; JianMin, Fen

doi:10.1016/j.ijbiomac.2008.06.008

Cited by 52 publications

(22 citation statements)

References 20 publications

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“…These results showed that RMO extract inhibiting bone loss might be irrelative to IL-6 and TNF-α. However, it has been reported that polysaccharides from Morinda officinalis could reduce the level of IL-6 and TNF-α in ovariectomized rats [ 26 ], which is not consistent with our results. Because the ethanol extract of Morinda officinalis mainly contains anthraquinones, and barely polysaccharides, it could not produce the same bioactivity as polysaccharides.…”

Section: Discussioncontrasting

confidence: 99%

Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats

Qin

Han

et al. 2009

Molecules

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The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-α and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.

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Section: Discussioncontrasting

confidence: 99%

Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats

Qin

Han

et al. 2009

Molecules

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“…They may act as both a suppressor of bone resorption and an enhancer of bone formation in vivo and may have some favorable effects for preventing and treating the osteoporosis induced by sciatic neurectomy and ovariectomy [67, 68]. The polysaccharides from Morinda officinalis can exert an increase in bone mineral density and mineral element concentration, a decrease in serum cytokines level in OVX rats [69]. The anthraquinones isolated from M. officinalis , have been proved to have inhibitory effects on osteoclastic bone resorption.…”

Section: Resultsmentioning

confidence: 99%

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

Jia

Nie

Cao

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Osteoporosis is a major health hazard and is a disease of old age; it is a silent epidemic affecting more than 200 million people worldwide in recent years. Based on a large number of chemical and pharmacological research many plants and their compounds have been shown to possess antiosteoporosis activity. This paper reviews the medicinal plants displaying antiosteoporosis properties including their origin, active constituents, and pharmacological data. The plants reported here are the ones which are commonly used in traditional medical systems and have demonstrated clinical effectiveness against osteoporosis. Although many plants have the potential to prevent and treat osteoporosis, so far, only a fraction of these plants have been thoroughly investigated for their physiological and pharmacological properties including their mechanism of action. An attempt should be made to highlight plant species with possible antiosteoporosis properties and they should be investigated further to help with future drug development for treating this disease.

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“…Zhang et al demonstrated that Lycium barbarum polysaccharides (LBP-4) were composed of six types monosaccharides that could enhance the food conversion rate and the content of Zn and Fe in mice [ 47 ]. Many trace elements were detected in Zn, Fe, and Cu in Morinda officinalis How, and polysaccharides extracted from M. officinalis How improved many trace elements, including Zn, Mg, and Ca, in ovariectomized rats [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Effects of Traditional Chinese Medicine for Poor Semen Quality in Infertile Males

Wang

et al. 2018

JCM

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Poor sperm quality is one of the main factors of male infertility. Traditional Chinese Medicine (TCM) has been used frequently in clinical practice in many countries to treat a wide array of infertile problems. To further understand the effects of TCM on semen quality, we retrospectively enrolled patients with male infertility and poor semen quality at the Tainan Municipal Hospital in Taiwan between 2013 and 2016. Semen quality analysis in accordance with the WHO criteria is an essential step in the evaluation of male fertility status. Associations between the semen parameters and body mass index, smoking status, alcohol use, duration of infertility, and age were also analyzed. A total of 126 male infertility patients with abnormal semen analysis were included in this study: 50 TCM users and 13 TCM non-users. The basic characteristics of the two groups were not significantly different. TCM users account for 92.5% of the total semen improvement subjects. In conclusion, TCM supplementation may have a beneficial role as improving sperm quality for infertility patients.

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Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats

Cited by 52 publications

References 20 publications

Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats

Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

The Therapeutic Effects of Traditional Chinese Medicine for Poor Semen Quality in Infertile Males

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