Protective effect of pomegranate (Punica granatum) extract against diabetic changes in adult male rat liver: Histological study

Faddladdeen, Khadija Abdul Jalil; Ojaimi, Ahlam Abdulaziz

doi:10.4103/jmau.jmau_6_19

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…Treatment of diabetic rats with F. carica , L. sativum , and P. granatum at the dosages used moderated the activity of those enzymes in plasma compared to the diabetic untreated group and thus alleviating the liver damage caused by STZ-induced diabetes [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Ramadan

Hegab

Al-Awthan

et al. 2021

Journal of Diabetes Research

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Background. Diabetes mellitus (DM) is a metabolic disorder characterized by high blood glucose levels that occurs either due to insufficient insulin production or mounting resistance to its action. The purpose of this study was to investigate if methanolic extracts of Lepidium sativum seeds, Ficus carica, and Punica granatum leaves had any effect on blood sugar levels in normal and streptozotocin (STZ) diabetic rats, as well as to explore the most effective extract. Method. Healthy male albino rats weighing 185-266 g were divided into nine groups of eight rats each: normal control, diabetic control, diabetic rats with dietary supplements of L. sativum, F. carica, and P. granatum methanolic extracts, and diabetics treated with insulin. All of the rats were fed on ordinary diet with nutritional pellets and were given water ad libitum. To induce diabetes, all animals were administered with STZ intraperitoneal injection at a dose of 60 mg/kg body weight. For five weeks, the crude plant extracts were given orally to various groups of rats at doses of one hundred and two hundred mg/kg body weight. After that, animal groups were sacrificed and blood samples were taken. Results. Phytochemical analysis revealed that the highest amounts of polyphenolic compounds were present in L. sativum seeds and P. granatum leaves, while leaves of F. carica showed the highest amounts of alkaloid and flavonoid content compared to other extracts. Oral administration of F. carica and L. sativum extracts at the dosage of 100 and 200 mg/kg significantly reduced glucose, lipid profile, kidney, and liver enzyme levels. A significant increase in HbAlc levels was also observed with L. sativum extract at a dose of 200 mg/kg compared to diabetic controls. Mellitus rats supplemented with 100 and 200 mg/kg methanolic extracts of P. granatum had higher serum triglycerides and lower serum low-density lipoprotein cholesterol (LDL-C) than normal control rats. F. carica extract is more effective than L. sativum and P. granatum extracts in the prevention and control of type 2 diabetes mellitus (T2DM) and its consequences.

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Section: Discussionmentioning

confidence: 99%

“…L. sativum [ 49 ] and P. granatum [ 50 , 51 ] significantly decreased blood glucose levels when compared to controls, with enhanced body weight, which could be attributed to better control of the diabetic rats' hyperglycemic state [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Ramadan

Hegab

Al-Awthan

et al. 2021

Journal of Diabetes Research

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“…In addition, the mixed solution of methanolic pomegranate peel powder was filtered twice. Finally, this mixture was evaporated at 50 °C using rotary evaporation (Rotavapor, Stuart, England) [ 28 ]. The resulting raw PPE was then red-balanced to 500 gm and kept in a deep freezer at 5 °C until further use in our experimental study.…”

Section: Methodsmentioning

confidence: 99%

Ameliorative Effect of Pomegranate Peel Extract (PPE) on Hepatotoxicity Prompted by Iron Oxide Nanoparticles (Fe2O3-NPs) in Mice

et al. 2022

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An evaluation of the ameliorative effect of pomegranate peel extract (PPE) in counteracting the toxicity of iron oxide nanoparticles (Fe2O3-NPs) that cause hepatic tissue damage is focused on herein. Forty male albino mice were haphazardly grouped into four groups as follows: the first control group was orally gavage daily with physiological saline; the second group received 100 mg/kg of PPE by the oral route day after day; the third group received 30 mg/kg Fe2O3-NPs orally; and the fourth group received both PPE and Fe2O3-NPs by the oral route, the same as the second and third sets. Later, after the completion of the experiment, we collected the liver, blood, and bone marrow of bone specimens that were obtained for further laboratory tests. For instance, exposure to Fe2O3-NPs significantly altered serum antioxidant biomarkers by decreasing the levels of total antioxidant capacity (TAC), catalase (CAT), and glutathione s-transferase (GST). Additionally, it caused changes in the morphology of hepatocytes, hepatic sinusoids, and inflammatory Kupffer cells. Furthermore, they significantly elevated the number of chromosomal aberrations including gaps, breaks, deletions, fragments, polyploidies, and ring chromosomes. Moreover, they caused a significant overexpression of TIMP-1, TNF-α, and BAX mRNA levels. Finally, the use of PPE alleviates the toxicity of Fe2O3-NPs that were induced in the hepatic tissues of mice. It is concluded that PPE extract has mitigative roles against the damage induced by Fe2O3-NPs, as it serves as an antioxidant and hepatoprotective agent. The use of PPE as a modulator of Fe2O3-NPs’ hepatotoxicity could be considered as a pioneering method in the use of phytochemicals against the toxicity of nanoparticles.

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“…Tashakori-Sabzevar et al, (2016) investigated the effects of celery seed extract on different biochemical factors and histopathological changes in normal and streptozotocin (STZ)induced diabetic rats reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Faddladdeen and Ojaimi (2019) found that pomegranate peel extract (PPE) against diabetic-induced hepatic complication reduced alanine aminotransferase, alanine phosphatase, and aspartate aminotransferase levels in rats. Table (5 It could be observed that the mean value of uric acid of control (+) group was higher than control (-) group, being 2.93±0.005 and 1.12±0.003 mg/dl respectively.…”

Section: ‫النوعية‬ ‫التربية‬ ‫مجاالت‬ ‫في‬ ‫البحوث‬ ‫مجلة‬mentioning

confidence: 99%

الدور المساهم لبذور الکرفس وقشور الرمان فی استعادة الحالة العادیة البیولوجیة والکیماویة الحیویة والهستولوجیة للفئران المصابة بارتفاع الکولیسترول

اليماني¹

2021

مجلة البحوث فی مجالات التربیة النوعیة

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This investigation aimed to evaluate the effect of celery seeds, pomegranate peel and mix diets on male hypercholesterolemic rats. Thirty (30) adult male Sprague Dawley rats were divided into five groups. Group (1): Normal rats fed on basal diet as control negative (C-), Group (2): Control positive (C+) (untreated group). Group (3): Hypercholesterolemic rats fed on basal diet and celery seeds (5%). Group (4): Hypercholesterolemic rats fed on basal diet and pomegranate peel (5%). Group (5): Hypercholesterolemic rats fed on basal diet and mix diets (5%). At the end of experiment, after 28 days of feeding, all serum samples were analyzed for biochemical parameters. Hypercholesterolemia caused a significant decrease in HDL while a significant increase was recorded in BWG, TC, TG, VLDL, LDL, U.A, creatinine, urea, AST, ALT, ALP and glucose. Hypercholesterolemic rats treated with various diets, showed the improvement in all previous parameters.

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Protective effect of pomegranate (Punica granatum) extract against diabetic changes in adult male rat liver: Histological study

Cited by 19 publications

References 25 publications

Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diabetic Rats

Ameliorative Effect of Pomegranate Peel Extract (PPE) on Hepatotoxicity Prompted by Iron Oxide Nanoparticles (Fe2O3-NPs) in Mice

الدور المساهم لبذور الکرفس وقشور الرمان فی استعادة الحالة العادیة البیولوجیة والکیماویة الحیویة والهستولوجیة للفئران المصابة بارتفاع الکولیسترول

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