Protective effect of prior administration of magnesium on delayed hyperalgesia induced by fentanyl in rats

Elstraete, Alain C. Van; Sitbon, Philippe; Mazoit, Jean Xavier; Conti, Marc; Benhamou, Dan

doi:10.1007/bf03021578

Cited by 12 publications

(7 citation statements)

References 30 publications

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“…Here, it is pertinent to mention that we used low doses of NMDA modulators that did not cause motor side‐effects in the mice. Our results with magnesium are consistent with a previous study that demonstrated the protective effect of magnesium against fentanyl‐induced hyperalgesia in rats 36 …”

Section: Discussionsupporting

confidence: 93%

N‐Methyl‐d‐aspartate receptor modulators block hyperalgesia induced by acute low‐dose morphine

Gupta¹,

Gupta²,

Tripathi³

2011

Clin Exp Pharma Physio

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1. Following opioid-induced antinociception in mice, hyperalgesic responses may be observed. The present study was designed to evaluate the effect of different N-methyl-d-aspartate (NMDA) receptor modulators (magnesium, dextromethorphan, d-serine) on the development of morphine-induced hyperalgesia in mice. The tail-flick test was used to assess the effects of morphine alone and in combination with the NMDA receptor modulators. 2. Administration of a single low dose (2 mg/kg) of morphine to mice produced antinociception that was followed by hyperalgesia. 3. Administration of magnesium sulphate (5 mg/kg) and d-serine (10 mg/kg) alone produced a transient antinociceptive response, whereas dextromethorphan (10 mg/kg) alone produced a prolonged antinociceptive response that had a relatively delayed onset after 4 h. 4. When coadministered with morphine, the NMDA receptor blockers magnesium (2 mg/kg) and dextromethorphan (2 and 5 mg/kg) and the NMDA receptor agonist d-serine (2, 5 and 10 mg/kg), maintained the duration of the antinociceptive response to morphine and inhibited the development of the hyperalgesic response. Coadministration of dextromethorphan (10 mg/kg) with morphine produced antinociception at 30-120 min and at 4-24 h. 5. The results of the present study suggest that coadministration of low-dose NMDA receptor antagonists, as well as the NMDA receptor agonist d-serine, with morphine can inhibit morphine-induced hyperalgesia.

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Section: Discussionsupporting

confidence: 93%

N‐Methyl‐d‐aspartate receptor modulators block hyperalgesia induced by acute low‐dose morphine

Gupta¹,

Gupta²,

Tripathi³

2011

Clin Exp Pharma Physio

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“…The main finding of our study was that either systemic or intrathecal delivery of gabapentin prevented the delayed hyperalgesia induced by short-term use of systemic fentanyl in uninjured rats. Our results are in accord with those of previous studies 3,20,21 and have confirmed that short-term use of systemic fentanyl in rats induces a delayed and sustained decrease in the nociceptive threshold below the basal value, i.e., the enhancement of pain sensitivity indicative of hyperalgesia. However, gabapentin had no analgesic effect per se and did not enhance the analgesic effect of various doses of fentanyl.…”

Section: Discussionsupporting

confidence: 93%

Gabapentin Prevents Delayed and Long-lasting Hyperalgesia Induced by Fentanyl in Rats

et al. 2008

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“…GBP gabapentin, mor morphine hyperreactivity [24]. The above mechanisms are involved in both fentanyl-and morphine-induced hyperalgesia [6,25,26]. Celerier [27] suggested that both antinociceptive and pronociceptive systems be upregulated after long opioid exposure, and the balance between antinociceptive and pronociceptive systems is broken as opioids are discontinued.…”

Section: Discussionmentioning

confidence: 97%

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

Wei

2011

J Anesth

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Protective effect of prior administration of magnesium on delayed hyperalgesia induced by fentanyl in rats

Cited by 12 publications

References 30 publications

N‐Methyl‐d‐aspartate receptor modulators block hyperalgesia induced by acute low‐dose morphine

N‐Methyl‐d‐aspartate receptor modulators block hyperalgesia induced by acute low‐dose morphine

Gabapentin Prevents Delayed and Long-lasting Hyperalgesia Induced by Fentanyl in Rats

Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats

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