Protective effect of probiotic bacteria and its nanoformulation against cadmium-induced oxidative stress in male Wistar rat

Al-Enazi, Amenah Mohmmad Monadi; Virk, Promy; Hindi, Awatif A.; Awad, Manal A.; Elobeid, Mai; Qindeel, Rabia

doi:10.1016/j.jksus.2020.08.011

Cited by 13 publications

(7 citation statements)

References 23 publications

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“…In another laboratory in vivo study, the administration of probiotic Lactobacillus paraplantarum BGCG11 significantly reduced AGE accumulation in parallel with inhibiting hyperglycemia, oxidative stress, DNA damage, liver and kidney fibrosis in rats with streptozotocin-induced diabetes (80). In another study, the administration of the commercial probiotic, Protexin ® , in Cd-exposed rats significantly reduced the serum MGO levels, as well as decreased tissue Cd accumulation and Cd-induced oxidative stress (81). Lactococcus lactis KF140 supplementation has also been shown to reduce serum CML levels and hepatic CML accumulation that may be at least partially mediated by activity of bacteria-derived β-galactosidase (82).…”

Section: Effects Of Gut Microbiota Modulation On Age Metabolism and T...mentioning

confidence: 94%

Role of gut microbiota in the modulation of the health effects of advanced glycation end‑products (Review)

et al. 2023

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The aim of the present review was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) accumulation and toxicity in the host, and to reveal potential the mediatory effects of the gut microbiota on AGE-related health effects. The existing data demonstrate that dietary AGEs can have a significant impact on the richness and diversity of the gut microbiota, although the particular effect is dependent on the type of species, as well as the exposure dose. In addition, the gut microbiota may metabolize dietary AGEs. It has been also demonstrated that the characteristics of the gut microbiota, including its richness and relative abundance of certain taxa, is tightly associated with AGE accumulation in the host organism. In turn, a bilateral interplay between AGE toxicity and the modulation of the gut microbiota may contribute to pathogenesis of ageing and diabetes-associated diseases. Bacterial endotoxin lipopolysaccharide appears as the molecule that mediates the interactions between the gut microbiota and AGE toxicity, specifically via the modulation of the receptor for AGE signaling. Therefore, it is proposed that the modulation of the gut microbiota using probiotics or other dietary interventions may have a significant impact on AGE-induced glycative stress and systemic inflammation. Contents1. Introduction 2. Bacterial AGE metabolism 3. The impact of dietary AGE exposure on gut microbiota characteristics and host metabolism 4. Involvement of AGE-gut microbiota interplay in disease pathogenesis 5. Effects of gut microbiota modulation on AGE metabolism and toxicity 6. Role of lipopolysaccharide in the interplay between microbiota and AGE toxicity 7. Conclusions and future perspectives

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Section: Effects Of Gut Microbiota Modulation On Age Metabolism and T...mentioning

confidence: 94%

Role of gut microbiota in the modulation of the health effects of advanced glycation end‑products (Review)

et al. 2023

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“…Interestingly, Amenah Mohmmad Monadi Al-Enazi et al (2020) illustrated that the metal-mediated generation of ROS can create severe oxidative damage in nucleic acids, such as strand breaks and base oxidation 8-OHdG. The exposure to Cd-containing nanoparticles showed a marked increment in the levels of 8-OHdG, which corresponds to the Cd-induced oxidative DNA damage, failure of DNA repair, and epigenetic instability …”

Section: Resultsmentioning

confidence: 99%

“…The exposure to Cd-containing nanoparticles showed a marked increment in the levels of 8-OHdG, which corresponds to the Cd-induced oxidative DNA damage, failure of DNA repair, and epigenetic instability. 45 In vivo effects of the model Cd nanocomplex demonstrated an ongoing inflammatory process caused by circulating inflammatory factors (e.g., IL-6, TGF-ß1) released, together with a general overexpression of IL-6. Cellular localization and distribution of IL-6 and TGF-ß1 revealed an increased expression of these cytokines as evidence of an enhanced cellular inflammatory response after administration of cadmium-containing nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

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Anchoring of Nanocomposites Based on Novel Metal Nanocomplexes/Nanocarbonaceous Surfaces and Assessing Their In Vivo Anticancer Effects on Ehrlich Ascites Tumor

2022

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Nanotechnology is the study of materials' unique properties at the nanoscale. Nanomedicine is the application of nanotechnology in medicine, which has been utilized to treat some common diseases, such as cancer. The aim of the present work is to synthesize the cadmium (Cd) nanocomplex using paracetamol as a ligand with a molar ratio of 1:2 M/L that was characterized by different physicochemical methods and to explore the effect of the synthesized Cd nanocomplex on the immune system and the redox status of the body and their anticancer effects on Ehrlich ascites carcinoma (EAC) induced in mice. Eighty female albino mice were separated into Group I: control; Group II: EAC; Group III: EAC treated with a low-dose Cd nanocomplex; and Group IV: EAC treated with a high-dose Cd nanocomplex. Interleukin-6 (IL-6), NLR family pyrin domain containing 3 (NLRP3), and 8-hydroxy 2-deoxyguanosine (8-OHdG) levels were assessed by enzyme-linked immunosorbent assay (ELISA). Peroxynitrite level and glutathione peroxidase activity were assessed by spectrophotometry. NRF2 mRNA expression, cadmium content, and liver and renal toxicity were estimated. Results: There was a significant increase in IL-6, NLRP3, 8-OHdG, peroxynitrite, and NRF2 mRNA expressions and in the glutathione peroxidase activity in EAC treated with lowand high-dose Cd nanocomplexes. However, the EAC treated with high-dose Cd nanocomplex group showed significant liver and renal toxicity. Conclusion: Cadmium nanocomplex has anticancer effects on EAC induced in mice via its effects on the immune system and redox status as well as pyroptosis and epigenetic instability of the body, while high doses of Cd nanocomplex can cause liver and renal toxicity.

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“…Both traditional probiotics and their nano counterparts are consistently being employed to address and mitigate the harmful effects of cadmium‐induced toxicity in Wistar rats. Furthermore, research suggests that the use of nano probiotics and probiotic additives could serve as a secure and efficacious approach to counter heavy metal toxicity and oxidative stress in these rats (Al‐Enazi et al., 2020). For instance, probiotics coated with nanoparticles have exhibited supportive potential in managing neuroinflammation, and they have also demonstrated improved outcomes in bolstering cancer immunotherapeutic functions (Hu et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Synergistic interaction of nanoparticles and probiotic delivery: A review

Vijayaram,

Razafindralambo,

Sun

et al. 2024

Journal of Fish Diseases

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Nanotechnology is an expanding and new technology that prompts production with nanoparticle‐based (1–100 nm) organic and inorganic materials. Such a tool has an imperative function in different sectors like bioengineering, pharmaceuticals, electronics, energy, nuclear energy, and fuel, and its applications are helpful for human, animal, plant, and environmental health. In exacting, the nanoparticles are synthesized by top‐down and bottom‐up approaches through different techniques such as chemical, physical, and biological progress. The characterization is vital and the confirmation of nanoparticle traits is done by various instrumentation analyses like UV–Vis spectrophotometry (UV–Vis), Fourier transform infrared spectroscopy, scanning electron microscope, transmission electron microscopy, X‐ray diffraction, atomic force microscopy, annular dark‐field imaging, and intracranial pressure. In addition, probiotics are friendly microbes which while administered in sufficient quantity confer health advantages to the host. Characterization investigation is much more significant to the identification of good probiotics. Similarly, haemolytic activity, acid and bile salt tolerance, autoaggregation, antimicrobial compound production, inhibition of pathogens, enhance the immune system, and more health‐beneficial effects on the host. The synergistic effects of nanoparticles and probiotics combined delivery applications are still limited to food, feed, and biomedical applications. However, the mechanisms by which they interact with the immune system and gut microbiota in humans and animals are largely unclear. This review discusses current research advancements to fulfil research gaps and promote the successful improvement of human and animal health.

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Protective effect of probiotic bacteria and its nanoformulation against cadmium-induced oxidative stress in male Wistar rat

Cited by 13 publications

References 23 publications

Role of gut microbiota in the modulation of the health effects of advanced glycation end‑products (Review)

Role of gut microbiota in the modulation of the health effects of advanced glycation end‑products (Review)

Anchoring of Nanocomposites Based on Novel Metal Nanocomplexes/Nanocarbonaceous Surfaces and Assessing Their In Vivo Anticancer Effects on Ehrlich Ascites Tumor

Synergistic interaction of nanoparticles and probiotic delivery: A review

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