Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells

Zhang, Xianglun; Liu, Xiaomu; Wan, Fachun; Wang, You; Tan, Xiaodong; Sheng, Qingkai; Li, Chuanhao; Hu, Zhuran; Liu, Guifen; Zhao, Hang

doi:10.1016/j.meatsci.2021.108724

Cited by 9 publications

(11 citation statements)

References 42 publications

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“…In the current study, supplementation with RAC tended to increase muscle gene expression of NRF2 compared to the preRAC period. Expression of NF-E2-related factor 2 expression is upregulated by ROS and increases intracellular anti-oxidant capacity by signaling for a variety of proteins with anti-oxidant function ( Chen et al, 2006 ; Xiao et al, 2019 ; Zhang et al, 2022 ). This supports the hypothesis that RAC induces some degree of oxidative stress in the muscle.…”

Section: Discussionmentioning

confidence: 99%

Effects of feeding aSaccharomyces cerevisiaefermentation product and ractopamine hydrochloride to finishing beef steers on growth performance, immune system, and muscle gene expression

Rients

Deters

McGill

et al. 2023

Journal of Animal Science

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The objective of this study was to determine impacts on immune parameters, anti-oxidant capacity, and growth of finishing steers fed a Saccharomyces cerevisiae fermentation product (SCFP; NaturSafe; Diamond V, Cedar Rapids, IA) and ractopamine hydrochloride (RAC; Optaflexx; Elanco Animal Health, Greenfield, IN). Angus-crossbred steers (N = 288) from two sources were utilized in this 90-d study. Steers were blocked by source, stratified by initial body weight to pens of six steers, and pens randomly assigned to treatments (16 pens per treatment). Three treatments compared feeding no supplemental SCFP (control; CON) and supplemental SCFP for 57 d (SCFP57), and 29 d (SCFP29) before harvest. Supplementation of SCFP was 12 g per steer per d, and all steers were fed RAC at 300 mg per steer per d for 29 d before harvest. Blood samples were collected from3 steers per pen, and muscle samples were collected from 1 steer per pen at 57, 29 (start of RAC), and 13 (midRAC) days before harvest. Blood was analyzed from 2 steers per pen for ferric reducing anti-oxidant power (FRAP). Muscle gene expression of myokines, markers of anti-oxidant and growth signaling were assessed. Individual animal BW were also collected on 57, 29, 13, and 1 d before being harvested at a commercial facility (National Beef, Tama, IA). Data were analyzed using the Mixed procedure of SAS 9.4 (Cary, NC) with pen as the experimental unit. The model included fixed effects of treatment and group. Increased BW compared to CON was observed days −29, −13, and −1 in SCFP57 steers (P ≤ 0.05), with SCFP29 being intermediate days −13 and −1. Overall G:F was improved in SCFP29 and SCFP57 (P = 0.01). On day −29, FRAP was greater in SCFP57 than CON (P = 0.02). The percent of gamma delta T cells and natural killer cells in both SCFP29 and SCFP57 was greater than CON on day −13 (P = 0.02). There were no treatment × day effects for muscle gene expression measured (P ≥ 0.25). Interleukin 6 tended to decrease in SCFP29 and SCFP57 on day −13 (P = 0.10). No other treatment effects were observed for muscle gene expression. Muscle gene expression of interleukin 15 was increased (P = 0.01), and expression of interleukin 8 was decreased (P = 0.03) due to RAC feeding. Increased growth in SCFP-fed cattle may be related to changes in anti-oxidant capacity and the immune system.

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Section: Discussionmentioning

confidence: 99%

Effects of feeding aSaccharomyces cerevisiaefermentation product and ractopamine hydrochloride to finishing beef steers on growth performance, immune system, and muscle gene expression

Rients

Deters

McGill

et al. 2023

Journal of Animal Science

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“…Cells were cultured at 37°C in 5% CO 2 humidity in 10% fetal bovine serum (FBS, Gibco) and 1% v/v penicillin/streptomycin (Gibco) in Dulbecco's modified Eagle's medium (DMEM, Gibco). For the DED cell model, HCEpiCs were treated with 0 or 94 mM NaCl in the medium and treated at isotonic and high osmolarity (312 and 500 mOsM) for 24 h. For resveratrol treatment, HCEpiCs were administered at 50 μ M, and the vehicle (alcohol) had a final concentration of 0.5% (nontoxic for cells) [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Ameliorative Potential of Resveratrol in Dry Eye Disease by Restoring Mitochondrial Function

Chen

Zhang

Zheng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background and Significance. Dry eye disease (DED) is a prevalent optic surface illness with a high incidence worldwide that is caused by a variety of factors, including mitochondrial dysfunction. Resveratrol has been confirmed to protect the eye surface in DED, and as an antioxidant, resveratrol can maintain mitochondrial function. Therefore, we investigated whether resveratrol can improve DED by restoring mitochondrial function. Methods. The mitochondrial dysfunction of HCE-2 human corneal epithelial cells was induced by high osmotic pressure exposure and treated with resveratrol (50 μM). Western blotting was used to detect the expression of the antioxidant proteins SOD2, GPx, and SIRT1, and flow cytometry was used to detect cell apoptosis and ROS production. The DED mouse model was induced by 0.2% benzalkonium chloride (BAC) and treated with resveratrol. The tear yield was measured by the phenol cotton thread test, the density of cup cells in the conjunctiva was measured by periodic acid-Schiff (PAS) staining, and the expression levels of SIRT1, GPx, and SOD2 in lacrimal glands were detected by Western blotting. Results. In hypertonic conditions, the apoptosis of HCE-2 cells increased, the expression of the antioxidant proteins SOD2 and GPx decreased, ROS production increased, and the expression of SIRT1 protein, an essential regulator of mitochondrial function, was downregulated. Treatment with resveratrol reversed the mitochondrial dysfunction mediated by high osmotic pressure. In the DED mouse model, resveratrol treatment promoted tear production and goblet cell number in DED mice, decreased corneal fluorescein staining, upregulated SIRT1 expression, and induced SOD2 and GPx expression in DED mice. Conclusion. Resveratrol alleviates mitochondrial dysfunction by promoting SIRT1 expression, thus reducing ocular surface injury in mice with dry eye. This study suggests a new path against DED.

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“…The emergence of antibiotic resistance in food-producing animals leads to public health issues in clinical settings, animal husbandry, and food industry. The options for treating infections are increasingly scarce due to an exponential increase in resistant and also multi-resistant strains [ 7 , 10 , 22 ].…”

Section: Food-producing Animals As One Of the Potential Sources Of Fo...mentioning

confidence: 99%

“…The increase in E. coli occurrence has been reported in diverse ecological niches, and its widespread availability allows for comparisons across relevant populations. It is considered a useful alert system and serves as a model for studying the emerging resistance in livestock and its possible spread to animal-derived food [ 22 , 26 ]. Both commensal and pathogenic E. coli have also been implicated in transferring resistance genes to other bacteria and can act as reservoirs of antibiotic resistance genes that may be transferred between bacterial species, including pathogenic ones.…”

Section: Food-producing Animals As One Of the Potential Sources Of Fo...mentioning

confidence: 99%

“…ESBLs are plasmid-mediated enzymes that hydrolyze the broad-spectrum β-lactam ring and confer antimicrobial resistance to β-lactams (penicillins, first-, second- and third-generation cephalosporins and aztreonam) but not cephamycins and carbapenems [ 24 , 32 , 33 ]. Beta-lactamases are divided into four different classes (A to D) based on their amino acid sequences; according to the Ambler system: class A (TEM, SHV and CTX-M β-lactamases), class C (CMY, DHA, and ACT) and class D (OXA) have a water molecule to hydrolyze β-lactam antibiotics, while class B utilize zinc ions to attack the reactive β-lactam ring and is characterized as metallo-β-lactamase [ 22 , 33 ]. The most common genetic type is CTX-M family of ESBLs, a heterogenous and complex group of enzymes that possibly derive from the relocation of chromosomal Kluyvera genes to mobile genetic elements, which is an important cause of transferable mult-drug resistance in E. coli .…”

Section: Food-producing Animals As One Of the Potential Sources Of Fo...mentioning

confidence: 99%

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Antimicrobial Resistance and Clonal Lineages of Escherichia coli from Food-Producing Animals

Silva

Pereira

et al. 2023

Antibiotics

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Escherichia coli are one of the most important pathogenic bacteria readily found in the livestock and widely studied as an indicator that carries drug-resistant genes between humans, animals, and the environment. The use of antimicrobials in the food chain, particularly in food-producing animals, is recognized as a significant contributor to the development and spread of antimicrobial resistance (AMR) and resistance genes can be transferred from the farm through the food-chain. The objective of this review is to highlight the background of the antimicrobials use in food-producing animals, more specifically, to study clonal lineages and the resistance profiles observed in E. coli, as well as in extended spectrum beta-lactamases (ESBL) producing E. coli, in a set of food-production animals with greater relevance in food consumption, such as pigs, poultry, cattle, fish farming and rabbits. Regarding the prevalence of ESBL-producing E. coli among farm animals, high-to-moderate prevalence was observed, and the highest resistance rates to tetracycline and ampicillin was detected in different farms in all geographic regions. Worldwide pandemic clones and high-risk zoonotic E. coli clones have been identified in most food-producing animals, and some of these clones are already disseminated in different niches, such as the environment and humans. A better understanding of the epidemiology of E. coli and ESBL-producing E. coli in livestock is urgently needed. Animal production is one of the major causes of the antibiotic resistance problem worldwide and a One Health approach is needed.

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Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells

Cited by 9 publications

References 42 publications

Effects of feeding aSaccharomyces cerevisiaefermentation product and ractopamine hydrochloride to finishing beef steers on growth performance, immune system, and muscle gene expression

Effects of feeding aSaccharomyces cerevisiaefermentation product and ractopamine hydrochloride to finishing beef steers on growth performance, immune system, and muscle gene expression

Ameliorative Potential of Resveratrol in Dry Eye Disease by Restoring Mitochondrial Function

Antimicrobial Resistance and Clonal Lineages of Escherichia coli from Food-Producing Animals

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