2014
DOI: 10.1016/j.pupt.2013.07.007
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Protective effect of resveratrol against endotoxemia-induced lung injury involves the reduction of oxidative/nitrative stress

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Cited by 46 publications
(50 citation statements)
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“…Resveratrol is known to exert potent anti-oxidant activities via scavenging ROS [22], as well as enhancing the activity of anti-oxidant enzymes such as catalase and glutathione peroxidase [24]. Accumulating data have shown that resveratrol alleviates LPS-induced oxidative stress in a variety of organs such as lung [12], kidney [25,26] and heart [27]. In the present study, we provided several line of evidence that resveratrol treatment significantly alleviated oxidative stress in the adrenal gland during endotoxemia.…”
Section: Resveratrol Improves Lps-induced Adrenal Insufficiencysupporting
confidence: 57%
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“…Resveratrol is known to exert potent anti-oxidant activities via scavenging ROS [22], as well as enhancing the activity of anti-oxidant enzymes such as catalase and glutathione peroxidase [24]. Accumulating data have shown that resveratrol alleviates LPS-induced oxidative stress in a variety of organs such as lung [12], kidney [25,26] and heart [27]. In the present study, we provided several line of evidence that resveratrol treatment significantly alleviated oxidative stress in the adrenal gland during endotoxemia.…”
Section: Resveratrol Improves Lps-induced Adrenal Insufficiencysupporting
confidence: 57%
“…Moreover, resveratrol increase iNOS activity in primary cultured rat vascular smooth muscle cells [36]. Although the above-mentioned literatures have reported that resveratrol treatment leads to enhanced expression or activity of iNOS, there are plenty of studies demonstrating that resveratrol decreases iNOS expression and NO production induced by various proinflammatory stimuli such as LPS [12] and interferon-γ [37]. Consistent with most of the literature in this area, we found that resveratrol significantly suppressed LPSinduced iNOS expression, NO production, and nitrotyrosine formation in the adrenal gland.…”
Section: Discussionmentioning
confidence: 96%
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“…Though not yet confirmed in a stroke model, resveratrol scavenges ONOO - and inhibits protein nitration in several other models [139,140,141]. Moreover, liquid chromatography with tandem electrospray mass spectrometry showed that resveratrol is a substrate of ONOO - .…”
Section: Active Compounds From Chinese Herbal Medicine For Targeting mentioning
confidence: 99%