Protective effect of resveratrol against hepatic damage induced by heat stress in a rat model is associated with the regulation of oxidative stress and inflammation

The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

“…These hepatoprotective effects are associated with the antioxidant and cleansing properties of RSV, through a reduction in the activity of xanthine oxidase, a partial restoration of GSH, in addition to its ability to inhibit apoptosis [105,106]. Resveratrol has also been shown to be protective against heat stress-induced hepatic damage [107]. Therefore, the role of resveratrol in liver protection against chemical damage derives mainly from its ability to suppress oxidative stress and apoptosis.…”

Effects of dietary chitosan oligosaccharides on oxidative stress and inflammation response in liver and spleen of yellow-feather broilers exposed to high ambient temperature

“…In health status, AST and ALT enzymes were normally expressed in liver, when liver damaged, AST and ALT enzymes released into the blood (Kim et al 2015), the elevated serum ALT and AST levels were served as marker of liver damage (Dufour et al 2000). Heat stress was known to induce liver damage (Zeng et al 2014), and increased serum AST and ALT levels (Tessari et al 2010;Cheng et al 2019b). As expected, dietary COS supplementation alleviated liver damage by decreasing serum AST and ALT levels under high ambient temperature.…”

“…Previous studies indicated that heat stress had negative effects on performance, health, and wellbeings of broilers (Lara and Rostagno 2013). Moreover, heat stress resulted in oxidative stress (Ando et al 1997), which, in turn, inducing adverse effects on DNA, protein, and lipids, and finally led to tissue damage, inflammatory disease, and some other diseases (Zhang et al 2018;Cheng et al 2019a;Cheng et al 2019b). Heat stress also induced inflammation response (Jang et al 2014;Ohtsu et al 2015;Wang et al 2018).…”

Effects of Early Resveratrol Intervention on Skeletal Muscle Mitochondrial Function and Redox Status in Neonatal Piglets with or without Intrauterine Growth Retardation

“…Resveratrol (trans-3,4 ′ ,5-trihydroxystilbene, RSV), a polyphenol isolated from plants such as grapes, peanut, and polygonum cuspidatum, has been described as exhibiting pleiotropic functions including antioxidative and antiinflammatory properties [10,11], antiobesogenic [12,13], antiatherosclerotic [14], and anticancer [15] activities. Previous studies conducted in rodents model demonstrated that RSV can govern glucose homeostasis under high-fat-dietinduced insulin resistance condition by improving mitochondrial ETC complexes activities and antioxidant function, and regulating the genes expression of mitochondrial biogenesis in skeletal muscle [16,17].…”