Protective Effect of Resveratrol against Hepatotoxicity of Cadmium in Male Rats: Antioxidant and Histopathological Approaches

Abstract

Cadmium (Cd) is widely used in some industries and emitted from fossil fuels. It is a heavy metal with a number of side effects, including hepatotoxicity. Resveratrol (Rs) is considered an important polyphenol, which is a secondary plant metabolite and has the ability to scavenge free radicals. The study was designed to evaluate the effects of resveratrol on Cd, which induced hepatotoxicity, by the assessment of some histopathological and biochemical alterations. Forty male albino rats were divided into four groups: the 1st group was the control group, the 2nd group was treated with Cd (5 mg/kg), the 3rd group was given Rs (20 mg/kg), and the 4th group was treated with Cd in combination with Rs intraperitoneally for 30 successive days. The results indicate that Cd increased liver enzymes alanine aminotransferase and aspartate aminotransferase (AST and ALT), alkaline phosphatase ALP and gamma-glutamyl transferase (γ-GT) while reducing the total protein level; Cd increased the malondialdhyde (MDA) level while decreasing the levels of other antioxidant enzymes super oxide dismutase, catalase and glutathione peroxidase (SOD, CAT and GPx). Serious congestion and hemorrhage related to the hepatic tissues were noticed in the Cd group, and Rs plays a major role in alleviating histopathological injuries and hepatic oxidative damage. It is clear that Rs has the ability to minimize the hepatotoxicity induced by Cd in male rats.

A mixture of Iranian probiotics had anti-inflammatory and antioxidative effects in oxidative injuries induced by cadmium in liver and blood parameters

“…This is in agreement with our results, revealing elevated ALP serum levels in Cd-treated rats. Extremely elevated levels of AST, ALT, and ALP were also observed in different animal [11,31]. In the present study, probiotic supplementation reduced Cd-induced hepatotoxicity as evidenced by lower levels of AST, ALT, and ALP, providing shielding against Cd-induced toxicity in rat models.…”

Morin encapsulated chitosan nanoparticles (MCNPs) ameliorate arsenic induced liver damage through improvement of the antioxidant system and prevention of apoptosis and inflammation in mice

“…21,22 The protective effects of curcumin, quercetin and resveratrol NPs against hepatic damage are well documented. 23,24 Chitosan NPs also show a promising protective role in the management of hepatic injury induced by acetaminophen, alcohol, diethylnitrosamine (DEN), CCl4, and concanavalin A. [25][26][27][28] In this respect the hepatoprotective activity of MCNPs against arsenic induced hepatotoxicity is quite justied.…”

Chemical Characterization of Taif Rose (Rosa damascena) Methanolic Extract and Its Physiological Effect on Liver Functions, Blood Indices, Antioxidant Capacity, and Heart Vitality against Cadmium Chloride Toxicity

“…This can result in a biological accumulation of CdCl 2 in multiple organs and an elevated burden on the body over time [ 7 ]. After absorption, CdCl 2 is distributed throughout the body primarily through blood circulation [ 8 , 9 ]. CdCl 2 alters the binding positions of metal ions, such as Ca 2+ , Zn 2+ , and Fe 3+ , on the membrane transport proteins, altering the permeability of cellular membranes and increasing its entry into the cells [ 10 ].…”