Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats

Abo-Youssef, Amira M.

doi:10.4103/0253-7613.169577

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…These studies indicated that quercetin seems to be more effective in antidiabetes than antiobesity. A similar result was found in quercetin‐fed male Wistar rats with the consumption of a high‐fructose diet, which was shown as a lowered plasma insulin and HOMA‐IR index . The quercetin (50 mg/kg body weight) treatment for 4 wk not only restored the high‐fructose diet‐caused reduction in adiponectin but also TNF‐α in epididymal adipose tissue of rats.…”

Section: Chemoprevention Potential Of Dietary Natural Compounds: Targsupporting

confidence: 75%

Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

Lai

et al. 2016

Molecular Nutrition Food Res

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Mitochondria are at the center stage in the control of energy homeostasis in many organs and tissues including adipose tissue. Recently, abundant evidence from experimental studies has clearly supported the strong correlation between mitochondrial dysfunction in adipocytes and obesity. Various physiological conditions such as excessive nutrition, genetic factors, hypoxia, and toxins disrupt mitochondrial function by impairing mitochondrial biogenesis, dynamics, and oxidative capacity. Mitochondrial dysfunction in adipocytes could have an impact on differentiation, adipogenesis, insulin sensitivity, and the significant alteration in their metabolic function, which ultimately results in obesity and type 2 diabetes. Numerous dietary natural compounds are the subject of research for the prevention and treatment of obesity through reprogramming multiple metabolic pathways. Some of them have the potential against obesity by modulating insulin signaling, decreasing oxidative damage, downregulating adipokines secretion, and increasing mitochondrial DNA that improves mitochondrial function and thus maintain metabolic homeostasis. Here, we focus on and summarize and briefly discuss the currently known targets and the mitochondria-targeting effects of dietary natural compounds in the intervention of obesity.

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Section: Chemoprevention Potential Of Dietary Natural Compounds: Targsupporting

confidence: 75%

Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

Lai

et al. 2016

Molecular Nutrition Food Res

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“…Several studies showed that high fat and high fructose diets induce insulin resistance and tissue damage. Excess fructose diet increases the lipid synthesis and metabolic diseases which cause lipotoxic cellular dysfunction and cause accumulation of lipids induces damages in the liver and kidney (Abo-youssef 2015 ; Hao et al 2015 ; De Castro et al 2013 ). The histology of kidney stained with H & E. Group 1 shows the normal architecture of the kidney (Plate 1).…”

Section: Resultsmentioning

confidence: 99%

Multivariate analysis and molecular interaction of curcumin with PPARγ in high fructose diet induced insulin resistance in rats

2016

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To investigate the effect of curcumin on the multivariate and docking analysis on peroxisome proliferator activated receptor-γ, the rats were fed with high fructose diet (Group 2) to induce insulin resistance and curcumin was co-administered orally (Group 4) for a period of 8 weeks and measured the biochemical parameters in blood, kidney and liver tissues. The results showed a significant (p ≤ 0.05) increase in the level of creatinine, glucose, insulin, low density lipoprotein, total cholesterol, triglyceride, urea, uric acid, very low density lipoprotein and decreased albumin, high density lipoprotein and total protein level in the blood of Group 2 when compared with Group 1 control rats. Further, analysis on liver and kidney tissues showed a significant decrease in antioxidants, hexokinase and increased glucose 6-phosphatase and fructose 1,6-bisphosphatase, hydroperoxides and TBARS in Group 2 rats. Furthermore, the multivariate and loading coefficient analysis showed that albumin, HDL, catalase, glutathione reductase, hexokinase and vitamin E are the most contributing factors in blood, liver and kidney. Subsequently, molecular docking was carried out to determine the binding efficiency of curcumin as agonist of PPARγ showed high affinity compared to pioglitazone. The histology of liver and kidney were also studied and the administration of curcumin along with fructose protects the organs from the abnormal changes and also prevents the fat accumulation. Overall, these results demonstrate the preventive role of curcumin on diet induced insulin resistant in rats by ameliorating the altered levels of metabolic changes and potential binding of curcumin with PPARγ as agonist in the treatment of insulin resistance.

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“…Insulin levels were measured using rat insulin enzyme-linked immunosorbent assay kit (Mercodia, Uppsala, Sweden) in serum. 11 …”

Section: Methodsmentioning

confidence: 99%

The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats

Chakraborty

Ahmed

Bhattacharjee

2017

Integrative Medicine Research

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BackgroundPomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications.MethodsDiabetes was induced via administration of alloxan (150 mg/kg, intraperitoneally). Rats (n = 8) were treated with pomegranate juice (PJ) [3 mL/animal, per os (p.o.)], TOL (20 mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method.ResultsThe combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL.ConclusionFrom this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction.

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Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats

Cited by 9 publications

References 29 publications

Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

Multivariate analysis and molecular interaction of curcumin with PPARγ in high fructose diet induced insulin resistance in rats

The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats

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