Protective Effect of Royal Jelly on Some Hematologic Parameters Against Sodium Arsenite Toxicity: A Study in Rats

Abstract

This study examined the effect of royal jelly on some hematological values against sodium arsenite (NaAsO2)-induced toxicity in rats. Royal jelly is a known functional bee product; therefore, its potential to protect against these effects is of great importance. In this study, the effects of royal jelly on hematologic changes were investigated. In the study, 35 healthy Wistar albino male rats weighing 250–300 g and 12–13 weeks old were used. Rats were divided into different groups by gavage daily for 14 days. WBC, LYM, MID, GRA, RBC, HGB, MCHC, MCH, MCV, HCT, PLT, MPV, and PDW values were measured in blood samples. When the measured values were analyzed, the MID, RBC, MCHC, MCH, MCV, and PDV values did not show statistical significance in all experimental groups (P>0.005). However, significant decreases in %LYM, %MID, HCT, and PLT values and increases in WBC, GRA, and %GRA counts were observed in all groups (P < 0.005). This review shows that royal jelly has a potential effect on the hematological and immune systems against toxicity caused by harmful heavy metals such as arsenic. In particular, further research is required to identify the most effective dosage of royal jelly. The results highlight the protective potential of royal jelly against toxicity, which requires further investigation.