Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

Kandemir, Fatih Mehmet; Çağlayan, Cüneyt; Aksu, Emrah Hicazi; Yıldırım, Serkan; Küçükler, Sefa; Gür, Cihan; Eser, Gizem

doi:10.1111/and.13524

Cited by 63 publications

(33 citation statements)

References 59 publications

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“…Apoptosis, programed cell death, occurs at certain limits in all tissues, including the testis (Celik, Kucukler, et al., 2020; Kandemir et al., 2020). However, the excessive occurrence of apoptosis in testicular tissues can lead to infertility in men due to some factors (Richburg, 2000).…”

Section: Discussionmentioning

confidence: 99%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

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In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered orally. In biochemical analysis of testicular tissue, it was found that PbAc-reduced antioxidant parameters [glutathione peroxidase (GPx), glu

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Section: Discussionmentioning

confidence: 99%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

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“…Metals also exert their toxic effects in such way that they lead to increased production of reactive oxygen species (ROS) that impair the redox homeostasis of the cell [12]. Phenolic compounds also exert a very important antioxidative function [13,14,15,16]. They have the potential to directly scavenge ROS and RNS (reactive nitrogen species), but also present endogenous substrates for vacuolar and apoplastic class III peroxidases.…”

Section: Introductionmentioning

confidence: 99%

The protective role of melatonin under heavy metal-induced stress in Melissa Officinalis L.

Hodžić¹,

Galijašević²,

Balaban³

et al. 2021

Turk J Chem

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Heavy metals, due to their inability to degrade, pose a serious environmental and nutritional problem. The accumulation of essential and non-essential heavy metals in living organisms reduces normal growth and development, resulting in acute poisoning, disease and even death of organisms. Melatonin is a very important multifunctional molecule in protecting plants from oxidative stress due to its ability to directly neutralize reactive oxygen species (ROS). Also, melatonin has a chelating property, which may contribute in reducing metal-induced toxicity. In this paper, the protective role of melatonin in counteracting metal-induced free radical generation was highlighted. Using the HPLC-FLD technique melatonin was identified and quantified in the roots and leaves of lemon balm (Melissa officinalis L.), grown under photoperiod conditions. Furthermore, the response of plants pre-treated with exogenous 0.1 mM melatonin to the increased zinc (Zn) and cadmium (Cd) concentrations was observed, with changes in mineral (Ca, Mg), physiological and antioxidant status of the plant during heavy metals stress. The obtained melatonin concentrations were the highest published for dry plants so far. Elevated Cd and Zn levels in soil caused alternation in biochemical and physiological parameters of lemon balm leaves and roots. However, melatonin pre-treatment increased plant tolerance to heavy metals stress. Increased Cd 3 and Zn uptake and their translocation into the leaves were also improved, indicating the possible use of melatonin in phytoremediation.

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“…Doku hasarının temelinde reaktif oksijen türlerinin (ROS) üretimindeki artışın yattığı yapılan çalışmalar ile ortaya konmuştur [22][23][24][25]. ROS'un aşırı üretimi nedeniyle oksidan/antioksidan denge bozulmakta, denge oksidan lehine dönerek oksitatif stress tetiklenmektedir [26][27][28].…”

Section: Discussionunclassified

Ratlarda Kadmiyum Kaynaklı Mide Toksisitesine Karşı Karvakrol’un Etkileri

Küçükler

Özdemir

Kandemir

et al. 2020

Türk Doğa Ve Fen Dergisi

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Sunulan çalışmanın amacı; ağır metallerden olan kadmiyumun (Cd) neden olduğu mide toksisitesine karşı karvakrol (Krv)'nin etkilerinin araştırılmasıdır. Çalışmada Spraque Dawley cinsi 35 adet erkek rat rastgele 5 gruba ayrıldı: Kontrol grubu, Cd uygulanan grup, Krv 50 mg kg-1 uygulanan grup, Cd + Krv 25 mg kg-1 uygulanan grup ve Cd + Krv 50 mg kg-1 uygulanan grup. Cd'nin glutatyon peroksidaz (GPx), süperoksit dismutaz (SOD) ve katalaz (KAT) gibi antioksidan enzim aktivitelerini ve glutatyon (GSH) düzeylerini azaltıp, lipid peroksidasyonunu (LPO) artırarak oksidatif hasara neden olduğu belirlendi. Ayrıca Cd ile kombine uygulanan Krv uygulamasının GSH seviyesini ve antioksidan enzim aktivitelerini arttırdığı, lipid peroksidasyonunu ise azalttığı tespit edildi. Çalışmada incelenen glikoz düzenleyici protein 78 (GRP78) mRNA transkipt seviyesinin Cd grubunda önemli şekilde arttığı, Krv uygulamasının ise bu gene ait ekspresyon seviyesini azalttığı belirlendi. Mide dokusunda Cd toksikasyonu aktive edici transkripsiyon faktör 6 (ATF6) ekspresyonunu arttırdığı, Krv uygulaması ile bu gene ait ekspresyonda düşüş meydana geldiği saptandı. Sonuç olarak; Cd kaynaklı mide toksisitesinde Krv'nin yararlı etkilerinin olduğu oksidanantioksidan denge ile GRP78 ve ATF6 ekspresyonları incelenerek tespit edildi.

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Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

Cited by 63 publications

References 59 publications

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

The protective role of melatonin under heavy metal-induced stress in Melissa Officinalis L.

Ratlarda Kadmiyum Kaynaklı Mide Toksisitesine Karşı Karvakrol’un Etkileri

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