Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats

Tawab, Azza M. Abd El; Shahin, Nancy N.; AbdelMohsen, Mona M.

doi:10.1016/j.cbi.2014.11.001

Cited by 66 publications

(45 citation statements)

References 60 publications

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“…Reduced glutathione (GSH) scavenges ROS by forming oxidized glutathione (GSSG) and other disulfides. Increased oxidative stress promotes the formation and efflux of GSSG, and glutathione reductase (GR) mediates the reduction of GSSG to GSH [46]. This reaction requires the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), which is provided by glucose-6-phosphate dehydrogenase (G6PD) of the pentose phosphate pathway [46].…”

Section: Discussionmentioning

confidence: 99%

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Akhigbe

Ajayi

2019

Preprint

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Background: Codeine, a 3-methylmorphine, and other related opioids have been implicated in androgen suppression, although the associated mechanisms remain unclear.Aim: Therefore, the objective of the current study was to elucidate the in vivo molecular mechanisms underlying codeine-induced androgen suppression.Methods: This study made use of Twenty-one healthy male rabbits, distributed into three groups randomly, control and codeine-treated groups. The control had 1ml of normal saline daily p.o.The codeine-treated groups received either 4mg/kg b.w of codeine or 10mg/kg b.w of codeine p.o. for six weeks. Reproductive hormonal profile, testicular weight, enzymes, oxidative and inflammatory parameters, histological examination and apoptosis marker were evaluated to examine the effects of codeine use.Key findings: Oral administration of codeine resulted in testicular atrophy and alterations in testicular histomorphology, elevated testicular enzymes, and suppression of circulatory and intratesticular testosterone. These changes were associated with a marked rise in oxidative markers, including oxidative DNA damage, inflammatory response, and caspase-dependent apoptosis.Significance: In conclusion, chronic codeine use resulted in testicular degeneration and testosterone suppression, which may be attributable to nitric oxide-/oxidativestress-mediated caspase-dependent apoptotic testicular cell death.

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Section: Discussionmentioning

confidence: 99%

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Akhigbe

Ajayi

2019

Preprint

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“…Activities of acid phosphatase (ACP) and alkaline phosphatase (ALP) were determined in the testes supernatant according to established methods (Shen and Lee 1984;Abd El Tawab et al 2014), which is based on the hydrolysis of p-nitrophenyl-phosphate in acid and alkaline medium, respectively. Lactate dehydrogenase-X (LDH-X) activity was determined according to established method which is based on the inter-conversion of lactate and pyruvate (Vassault 1983).…”

Section: Evaluation Of Activities Of Marker Enzymes Of Testicular Funmentioning

confidence: 99%

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain–pituitary–gonadal axis in male rats

Adedara

Olabiyi

Ojuade

et al. 2017

Can. J. Physiol. Pharmacol.

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“…CYP has also been associated with gonadal toxicity in male and female survivors of adult or childhood cancers (Kenney, Laufer, Grant, Grier, & Diller, 2001;Thomson et al, 2002); and patients treated for noncancer related pathologies like rheumatic diseases (Dooley & Nair, 2008;Silva, Bonfa, & Ostensen, 2010), myasthenia gravis and lupus glomerulonephritis (Slater, Liang, McCune, Christman, & Laufer, 1999;Wetzels, 2004). CYPinduced gonadal toxicity in humans (Dooley & Nair, 2008;Wetzels, 2004) and rodents (Çeribaşi, Türk, Sönmez, Sakin, & Ateşşahin, 2010;El Tawab, Shahin, & AbdelMohsen, 2014;Kim et al, 2013) is associated with oligospermia, azoospermia, alterations in gonadotrophin, alterations in testosterone levels/oxidative stress parameters and testicular tissue toxicity. CYP disrupts cell growth, differentiation and function, mainly by cross-linking DNA strands (Vernet, Aitken, & Drevet, 2004); and there are suggestions that CYP (either alone, or in combination with other agents) damages the germinal epithelium (Ginsberg, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Its effect on rapidly proliferating tissues (which is predominant in the gonad) has also been considered as the basis of either its therapeutic or toxic potential (Ghobadi, Moloudizargari, Asghari, & Abdollahi, 2017). CYPinduced gonadal toxicity in humans (Dooley & Nair, 2008;Wetzels, 2004) and rodents (Çeribaşi, Türk, Sönmez, Sakin, & Ateşşahin, 2010;El Tawab, Shahin, & AbdelMohsen, 2014;Kim et al, 2013) is associated with oligospermia, azoospermia, alterations in gonadotrophin, alterations in testosterone levels/oxidative stress parameters and testicular tissue toxicity. In male rodents, there have been reports of reduction in testicular weight/testosterone levels and infertility (El-Alfy, Isa, Mahmoud, & Emam, 2013;Elangovan, Chiou, Tzeng, & Chu, 2006;Singh, Lata, & Tiwari, 2015) following administration of CYP.…”

Section: Introductionmentioning

confidence: 99%

Cyclophosphamide-induced male subfertility in mice: An assessment of the potential benefits of Maca supplement

2017

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Effects of Lepidium meyenii (Maca) on cyclophosphamide (CYP)-induced gonadal toxicity in male mice were investigated. Mice were assigned to six treatment groups: Vehicle control, CYP control, CYP plus oral Maca (500 or 1,000 mg/kg), and oral Maca (500 or 1,000 mg/kg). CYP was administered via the intraperitoneal route (days 1-2), while vehicle or Maca were administered daily for 28 days. On day 28, half of the animals in each group were either sacrificed or paired with age-matched females for fertility assessment. Plasma testosterone assay, sperm analysis and assessment of tissue antioxidant/morphological status were also carried out. CYP administration was associated with oxidative stress, subfertility and morphometric/morphological indices of gonadal injury, while administration of Maca mitigated CYP-induced gonadal toxicity and subfertility. This study shows that Maca is beneficial in the mitigation of CYP-induced male gonadal insufficiency and/or testicular morphological changes; however, further studies will be needed to ascertain its usability for this purpose in humans.

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Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats

Cited by 66 publications

References 60 publications

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain–pituitary–gonadal axis in male rats

Cyclophosphamide-induced male subfertility in mice: An assessment of the potential benefits of Maca supplement

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