Protective Effect of Sciadopitysin against Isoproternol-Induced Myocardial Infarction in Rats

Abstract

The current study enumerates the beneficial role of sciadopitysin (SDN) against isoproternol (ISO)-induced myocardial infarction (MI) in rats. The MI was experimentally induced via subcutaneous injection of ISO in experimental rats. SDN showed to prevent myocardial necrosis via reducing the levels of creatine kinase-MB and lactate dehydrogenase activities. It also showed to improve myocardial ability and decrease infarct volume. The level of cardiac-specific troponin-T (Tn-T), tumor necrosis factor-α and interleukin-6 were showed to be declined in SDN-treated group as determined by ELISA analysis. At the tested dose, SDN causes reduction in oxidative stress via enhancing the levels of glutathione peroxidase and superoxide dismutase, while reducing the level of myeloperoxidase and malondialdehyde. Cardiac histological changes were observed via hematoxylin and eosin staining along with cardiac function after preand post administration of SDN. In western blot analysis, SDN showed significant downregulation of cleaved caspase-3 and Bax, whereas Bcl-2 expression was found to be significantly elevated in dose-dependent manner.

Activation of PI3K/PKB/GSK‐3β signaling by sciadopitysin protects cardiomyocytes against high glucose‐induced oxidative stress and apoptosis

“…[20] Sciadopitysin exerted protective effects on isoproterenol-induced myocardial infarction via reducing inflammation, oxidative stress, and apoptosis in rats. [14] Furthermore, sciadopitysin reduced or prevented antimycin A-induced osteoblasts degeneration via its antioxidant activity in osteoblastic MC3T3-E1 cells. [15] Similarly, a previous study manifested that sciadopitysin prevented the development of diabetic osteopathy, a diabetic complication, via inhibiting MG-induced glycation in MC3T3-E1 cells.…”

“…[13] Sciadopitysin is an amentoflavone-type biflavonoid contained in Taxus chinensis, which exerts anti-inflammatory and antioxidative roles. [14][15][16] However, the potential effects of sciadopitysin on DCM remain poorly undefined.…”

Phytochemical profile, Ethnobotanical and Biological Impacts of Various Zamia Species: A Mini-Review

“…The level of cardiacspecific troponin-T (Tn-T), tumor necrosis factor-α, and interleukin-6 were shown to be declined in SDNtreated group as determined by ELISA analysis. 27 Osteoblastic MC3T3-E1 cells pretreated with sciadopitysin prior to antimycin A exposure significantly reduced antimycin A-induced cell damage by preventing mitochondrial membrane potential dissipation, adenosine triphosphate (ATP) loss, and reactive oxygen species (ROS) release, suggesting that sciadopitysin has an antioxidant ability that may be useful for protecting mitochondria against a burst of oxidative stress. 28 Sciadopitysin exhibited a strong inhibitory effect on Cladosporium oxysporum at ED50 value of 9 μmol/L.…”

Radioprotective Effect of Zinc Nanoparticles on Ionizing Radiation-induced Nephrotoxicity in Mice

“…IR induces different biochemical and molecular signaling pathways that can culminate in permanent physiological changes and even cell death [6]. The generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an important side effect of IR, and these oxidative stresses may continue for many days after initial radiation therapy [7][8][9]. The effects of IR are not only observed in irradiated cells, but it in their next generation as well as other normal cells and their offspring [10]; these cells experience a wide range of oxidative disorders such as protein carbonylation and lipid peroxidation [11].…”