Protective effect of selenium against mercury‐induced toxicity on hematological and biochemical parameters of Oreochromis niloticus

Abstract

In this study, to identify mercury (Hg) toxicity and whether selenium (Se) has any role in alleviation of this toxicity, it was investigated the changes in hematological and serum biochemical parameters of Oreochromis niloticus. Fish were exposed to 0.01 and 0.1 mg/L Hg and 0.01 mg/L Hg + 0.1 mg/L Se and 0.1 mg/L Hg + 1.0 mg/L Se for 7 and 14 days. The exposure of O. niloticus to Hg alone resulted in decreases in red blood cell, white blood cell, hemoglobin, hematocrit values, and cholinesterase activity while it increased in alanine aminotransferase and aspartate aminotransferase activities and cortisol and glucose levels. Se, in combination with Hg, partially or totally caused an alleviation for the toxic effect of Hg on the above mentioned hematological and biochemical parameters. The results of our study showed that Se has a protective effect against toxicity induced by Hg.

Supplementation of Calcium and Selenium Against Cadmium Induced Bioaccumulation in Selected Tissues of Fresh Water Fish, Oreochromis Mossambicus

“…The principle role of Se is associated with the control of LPO, because Se was a component of selenoenzymes contributing to the antioxidant system. Recently Cogun et al, [65] also reported the protective effect of Se against heavy metal Hg toxicity in Oreochromis niloticus. Lazarus et al,[23] also evaluated the influence of Se on Cd retention in suckling rats.…”

Selenium in the therapy of neurological diseases. Where is it going?

“…From the whole family of GPxs, only two isoforms, GPx1 and GPx4, have been detected in the human brain, both in the neurons and in glial cells [38]. GPx1, a widespread selenoenzyme mainly expressed in astroglial cells, is responsible for detoxifying hydrogen peroxides and alkyl hydroperoxides, thus limiting their deleterious effects [36]. Decreased activity of this enzyme resulted in higher brain vulnerability to oxidative damage induced by various toxins.…”

“…Its regional expression differs between the time of embryogenesis and after birth [36]. Firstly, GPx4 mRNA exists in the neural tube and later in the neuroepithelium of the fore-, mid-, and hind-brain in the embryo [42].…”

“…Firstly, GPx4 mRNA exists in the neural tube and later in the neuroepithelium of the fore-, mid-, and hind-brain in the embryo [42]. During postnatal development, GPx4 mRNA is the highest at postnatal day 15, with a gradual decline thereafter [36]. This enzyme is involved in the elimination of phospholipid hydroperoxides, however its detailed role in the central nervous system is unknown.…”

Antagonistic effect of selenium on lead-induced inflammatory injury through inhibiting the nuclear factor-κB signaling pathway and stimulating selenoproteins in chicken hearts

“…Selenium (Se) is an essential micronutrient and can antagonize different heavy metal toxicities 16 and hepatocellular carcinoma. 17 Se plays an important role in maintaining normal cardiovascular function.…”