Protective Effect of Sika Deer (<i>Cervus nippon</i>) Velvet Antler Extract against Cisplatin-Induced Kidney and Liver Injury in a Prostate Cancer PC-3 Cell Xenograft Model

Tang, Yujiao; Fan, Meiqi; Choi, Youngjin; Choi, Eun‐Ju; Moon, Sang-Ho; Debnath, Trishna; Yu, Yonghai; Lee, Il Nam; Kim, Eun-Kyung

doi:10.1155/2018/6705156

Cited by 3 publications

(2 citation statements)

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“…The ancient literary works provide evidence of the favorable impact of deer heart on cardiac well-being, thereby highlighting its potential therapeutic significance. In contrast, there exist a plethora of scholarly investigations into the diverse medicinal properties of deer antler velvet, leaving deer heart as a relatively neglected subject of scientific inquiry [ 33 , 34 ]. Consequently, this valuable organ, considered a byproduct of the deer industry, frequently falls victim to wastage.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Deer Heart Peptide on Cardiac Injury in Mice

Zhang,

Li,

Jia

et al. 2024

International Journal of Inflammation

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Peptides are widely used as natural bio-small molecules because of their various pharmacological activities such as enhancing immunity, promoting wound healing, and improving inflammation. Alcoholic heart injury has become one of the major health problems worldwide, and alcohol consumption is now the main cause of alcoholic cardiomyopathy. In this study, deer heart peptides were extracted from deer hearts by enzymatic digestion and the antioxidant activity of deer heart peptides extracted at different times was evaluated by three in vitro antioxidant methods, and the active peptide with the best enzymatic effect has been selected for in vivo animal experiments. The anti-inflammatory and antioxidant properties of deer heart enzymatic extracts were evaluated in in vivo experiments in mice. In this study, mice were orally gavaged with white wine (12 mL/kg body weight) to induce a mouse model of cardiac injury, while mice were orally administered a single dose of 100 mg/kg/bw and 200 mg/kg/bw of deer heart enzyme digest and were examined for body weight, dietary intake, water intake, and coat gloss, as well as for general behaviors, adverse effects, and mortality. Histology, serum, anti-inflammatory factors, and oxidative stress parameters were subsequently assessed. In all modeled mice, no four-way or any significant behavioral changes were observed in all groups, but in the modeled group, mice showed weight loss, decreased diet and water intake, and decreased cardiac index. For in vivo tests, the extract inhibited the anti-inflammatory activity with a significant decrease in inflammatory factors of TNF-α, IL-6, and IL-1β in cardiac tissues, a significant increase in serum levels of both CAT and SOD, an increase in MDA content, and a remarkable increase in the level of the marker CK in the cardiac myocardial enzyme profile. Significant improvement in myocardial disorders by deer heart peptide could be observed from heart tissue sections. The present study emphasizes the anti-inflammatory and antioxidant activity of deer heart peptide, an enzymatic digest of deer heart, which provides empirical as well as supportive role for the anti-inflammatory properties of traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Deer Heart Peptide on Cardiac Injury in Mice

Zhang,

Li,

Jia

et al. 2024

International Journal of Inflammation

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“…Modern pharmacology studies have revealed that the active ingredients in sika deer antler include proteins, peptides, amino acids, phospholipids, fatty acids, polyamines, and polysaccharides [ 13 ]. It has been reported that sika deer antler extract can protect against cisplatin-induced liver and kidney injury [ 14 , 15 ]. Among the variety of components comprising sika deer antler, proteins are recognized as the main effective substances.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Combined with Metabolomics Reveal the Mechanisms of Sika Deer Antler Protein on Cisplatin-Induced Hepatorenal Injury in Mice

Wang,

Li,

Wang

et al. 2023

Molecules

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Cisplatin is a widely used antineoplastic drug, though its adverse effects, particularly its hepatorenal toxicity, limit its long-term application. Sika deer antler is a valuable traditional Chinese medicine (TCM) documented to possess the capacity for tonifying the kidney and regulating the liver, of which the sika deer antler protein is an important active ingredient. In this study, two protein fractions, SVPr1 and SVPr2, of sika deer antler were purified and administered to mice treated with cisplatin, and serum metabolome and fecal microbiota were measured using ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and 16S rRNA gene sequencing. SVPr1 and SVPr2 significantly ameliorated cisplatin-induced liver and kidney injury and reduced mitochondrial dysfunction, oxidative stress, inflammatory response, and apoptosis. In addition, SVPr1 and SVPr2 impacted the gut microbiota structure of mice, significantly increasing the relative abundances of Lactobacillus, which deserves to be scrutinized. Moreover, SVPr1 and SVPr2 antagonism of cisplatin-induced hepatorenal injury may be related to the regulation of lysine degradation, tryptophan metabolism, and riboflavin metabolism pathways, significantly altering the levels of L-saccharopine, L-lysine, L-kynurenine, 3-methylindole, xanthurenic acid, riboflavin, and D-ribulose-5-phosphate. A correlation between the differential metabolites and Lactobacillus was identified. These findings increased the knowledge of the gut microbiota–metabolites axis mediated by SVPr1 and SVPr2, and may be able to contribute to the development of new therapeutic strategies for the simultaneous prevention and treatment of liver and kidney injury from cisplatin treatment.

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