Protective effect of sodium molybdate on the acute toxicity of mercuric chloride. V. Enhancement of renal regeneration after exposure to HgCl2

Protective mechanism of sodium molybdate against the acute toxicity of cadmium in rats. II. Prevention of cytoplasmic acidification

“…Molybdenum, however reduces the ability of rats to respond to temperature stress through unknown mechanism (Winston et al, 1973) Recently, we found that pretreatment of rats with Na2MoO4 protected them against the acute toxicity of CdC12 as well as against that of I-IgC12 (Yamane and Koizumi, 1982;Yamane et al, 1990). The mechanism by which molybdenum pretreatment alleviated the acute toxicity of those metals has not been explained fully, although it is evident that it, in part, involves the prevention of deregulation of inorganic cation metabolism such as cellular potassium loss and calcium increase and stimulation of metaUothionein synthesis in the liver and kidney (Yamane et al, 1990;Koizumi and Yamane, 1984;Koizumi and Yamane, 1984;Koizumi and Yamane, 1988). Considering the fact, however, that cadmium-or mercuryinduced irreversible cell damage seems to attribute to the alteration of cell membrane function such as disturbance of ion transports occurring in the liver and kidney within 2 hr after exposure to those metals (McDoweU et al, 1976;Doudley et al, 1984) and the fact that the rate of synthesis of metallothionein, being capable of detoxifying those metals by sequestration, increases to a maximum 4-8 hr after exposure to those metals Hildebrand et al, 1982), it is speculated that molybdenum pretreatment may reduce cadmiumor mercury-induced toxicity by ameliorating the harmful action of those metals on the cell membrane.…”