Protective effect of stimulated splenic transplants against rodent malaria ? preliminary results

Pabst, Reinhard; Westermann, Jürgen; Hillebrand, J.; Hafke, Robert

doi:10.1007/bf00189172

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…All operations were carried out under clean conditions with ether anesthesia. The splenectomy and splenic transplantation were performed as described before [8,9,11]. In brief, after splenectomy half of the spleen was cut into three to five slices and transplanted into the greater omentum.…”

Section: Infection With Malariamentioning

confidence: 99%

“…The functional capacity of splenic transplants after stimulating the white pulp was tested by measuring the protection afforded against rodent malaria, since it is known that the spleen plays an important role in malaria infection [19,23]. A surprising result was that stimulated transplants did not provide better protection than saline-injected controls [11]. Since the removal of the malaria parasites is also a function of the redpulp, the red pulp was stimulated by injections of phenylhydrazine (PHZ).…”

Section: Introductionmentioning

confidence: 99%

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Malaria infection in rats with stimulated splenic red pulp: The blood flow and protective effect in normal and transplanted splenic tissue

Westermann

Pabst

1988

Res. Exp. Med.

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After splenic autotransplantation both weight and blood flow of the regenerated splenic tissue are decreased. In addition, the protective function of the transplant is less compared to that of the normal spleen. In the present study, the red pulp of normal and transplanted splenic tissue was stimulated by injections of phenylhydrazine to increase the weight, the blood flow, and the protective function. After stimulation, the weight of the normal spleen increased to 900 +/- 70 mg (control 530 +/- 20 mg) and the transplanted tissue to 240 +/- 70 mg (control 70 +/- 20 mg). This enlargement was caused by an increase in the splenic red pulp. However, the relative blood flow decreased in both the normal spleen and the transplant to 50% of the normal value. To evaluate the protective function of the stimulated splenic tissue, normal, splenectomized and transplanted rats were infected with Plasmodium berghei. Despite the dramatic increase in the red pulp, neither the normal nor the transplanted animals showed a survival rate superior to that of the splenectomized animals. The mass of splenic tissue obviously does not correlate with the protective effect of the spleen in parasitic infections.

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Section: Infection With Malariamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%