Protective Effect of Sulfamethylthiazol on Experimental Salmonella enteritidis Infection in Mice

Studies Pertaining to the Antibacterial Activity of Sulfathiazole and its Methyl Derivative

“…The protective effect of sulfamethylthiazole against S. enteritidis infection in mice was reported in a previous publication of Muir, Shamleffer, and Jones (1940). In those experiments, sulfamethylthiazole was administered per os on a dosage basis of two grams per kilogram of body weight, two such doses each day.…”

“…The present report represents a more detailed and extended presentation of experimental data pertaining to the antibacterial activity of the thiazole compounds and their possible mode of action than those previously published from this laboratory (Muir, Shamleffer, and Jones, 1940, 1941a, and 1941b. In the present instance it is our purpose (a) to show that synthetic media are distinctly superior to the conventionally employed peptone-containing media for such studies, (b) to present a detailed appraisal of the inhibitory effect of the thiazole drugs on cellular proliferation, (c) to demonstrate the drug-antagonistic effect of p-aminobenzoic acid and other substances in a strictly synthetic medium, and (d) to compare the antibacterial effect of the thiazole compounds as observed in vivo.…”