Protective effect of sulfurous water in peripheral blood mononuclear cells of Alzheimer's disease patients

Guzmán, Rodrigo; Campos, Cristian H.; Yuguero, Rosario Saez; Masegù, C.; Gil, Pedro; Moragón, Ángela Casado

doi:10.1016/j.lfs.2015.04.006

Cited by 8 publications

(6 citation statements)

References 55 publications

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“…Supplementation with the slow-releasing H 2 S donor NaGYY rescues the diminished sulfhydration levels in the brains of 3xTg-AD mouse model and alleviates motor and cognitive deficits. Our findings concur with reports of diminished H 2 S levels in serum of AD patients and confirm the neuroprotective role of H 2 S donors in rodent models of AD (42,43,64,65,69,71,72). Treatment with H 2 S donors ameliorated several deficits, including those in learning and memory.…”

Section: Discussionsupporting

confidence: 92%

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Giovinazzo

Bursać

Sbodio

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

172

106

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Alzheimer’s disease (AD), the most common cause of dementia and neurodegeneration in the elderly, is characterized by deterioration of memory and executive and motor functions. Neuropathologic hallmarks of AD include neurofibrillary tangles (NFTs), paired helical filaments, and amyloid plaques. Mutations in the microtubule-associated protein Tau, a major component of the NFTs, cause its hyperphosphorylation in AD. We have shown that signaling by the gaseous molecule hydrogen sulfide (H2S) is dysregulated during aging. H2S signals via a posttranslational modification termed sulfhydration/persulfidation, which participates in diverse cellular processes. Here we show that cystathionine γ-lyase (CSE), the biosynthetic enzyme for H2S, binds wild type Tau, which enhances its catalytic activity. By contrast, CSE fails to bind Tau P301L, a mutant that is present in the 3xTg-AD mouse model of AD. We further show that CSE is depleted in 3xTg-AD mice as well as in human AD brains, and that H2S prevents hyperphosphorylation of Tau by sulfhydrating its kinase, glycogen synthase kinase 3β (GSK3β). Finally, we demonstrate that sulfhydration is diminished in AD, while administering the H2S donor sodium GYY4137 (NaGYY) to 3xTg-AD mice ameliorates motor and cognitive deficits in AD.

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Section: Discussionsupporting

confidence: 92%

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Giovinazzo

Bursać

Sbodio

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

172

106

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“…The study of Liang et al demonstrated that skin regenerative properties of Nagano spring water were related to the spring water chemical composition, with no influence of microorganisms [ 31 ]. Another beneficial effect that could be ascribed to ALI and GR according to their chemical composition is the protective effect against oxidative stress due to the presence of sulfur [ 114 ].…”

Section: Resultsmentioning

confidence: 99%

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

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Background: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.

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“…Fioravanti and co-workers [ 105 ] demonstrated that sulfated thermal waters inhibit nitric oxide (NO) production and apoptosis induced by IL-1β in OA chondrocytes. Moreover, another investigation showed that sulfurous water had higher antioxidant capacity against pro-oxidant stimuli than classical reference antioxidants compounds, leading to a protective effect on DNA stability and cell viability of peripheral blood mononuclear cells (PBMC) of both Alzheimer’s disease patients and healthy controls [ 106 ]. Furthermore, there is evidence that H 2 S treatment reduces both spontaneous and IL-1β-induced secretion of IL-6, IL-8 and RANTES, as well as the expression of MMP-2 and MMP-14 in cultured fibroblast-like synoviocytes from OA patients [ 107 ].…”

Section: Balneotherapy As a Hormetic Strategymentioning

confidence: 99%

Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy?

Gálvez

Torres-Piles

Ortega

2018

IJMS

138

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Balneotherapy is a clinically effective complementary approach in the treatment of low-grade inflammation- and stress-related pathologies. The biological mechanisms by which immersion in mineral-medicinal water and the application of mud alleviate symptoms of several pathologies are still not completely understood, but it is known that neuroendocrine and immunological responses—including both humoral and cell-mediated immunity—to balneotherapy are involved in these mechanisms of effectiveness; leading to anti-inflammatory, analgesic, antioxidant, chondroprotective, and anabolic effects together with neuroendocrine-immune regulation in different conditions. Hormesis can play a critical role in all these biological effects and mechanisms of effectiveness. The hormetic effects of balneotherapy can be related to non-specific factors such as heat—which induces the heat shock response, and therefore the synthesis and release of heat shock proteins—and also to specific biochemical components such as hydrogen sulfide (H2S) in sulfurous water and radon in radioactive water. Results from several investigations suggest that the beneficial effects of balneotherapy and hydrotherapy are consistent with the concept of hormesis, and thus support a role for hormesis in hydrothermal treatments.

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Protective effect of sulfurous water in peripheral blood mononuclear cells of Alzheimer's disease patients

Cited by 8 publications

References 55 publications

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy?

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