Protective effect of the hydro-alcoholic extract of Rubia cordifolia roots against ethylene glycol induced urolithiasis in rats

Divakar, Kalyani; Pawar, Anil T.; Chandrasekhar, Srinivasan; Dighe, S. B.; Goli, Divakar

doi:10.1016/j.fct.2010.01.011

Cited by 109 publications

(77 citation statements)

References 13 publications

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“…The excretion of oxalate and calcium were increased in curative group animals which is consistent with the previous reports [33,34]. Increased urinary calcium is a factor favouring the nucleation and precipitation of calcium oxalate or apatite (calcium phosphate) from urine and subsequent crystal growth [35].…”

Section: Discussionsupporting

confidence: 80%

A Study on Antiurolithiatic Activity of Melia Azadirachta L. Aqueous Extract in Rats

Hwisa¹,

Assaleh²,

Gindi³

et al. 2014

AJPS

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The objective was to investigate the antiurolithiatic activity of aqueous plant extract of Melia azadirachta using the zinc disc implantation model in male Wistar albino rats. A significant increase in urinary excretion of calcium, oxalate, magnesium and phosphate was observed after four weeks of implantation of zinc discs. After treatment with aqueous extract of Melia azadirachta caused a significant reduction (p < 0.001) in stone weight and urinary excretion of electrolytes in both the preventive and curative group of animals as compared to those of control groups. This explains the effect of the aqueous extract of Melia azadirachta in preventing urolithiasis (59%) and dissolving the pre-formed magnesium ammonium phosphate type of stones (46%). The possible mechanism could be due to the urinary stone-formation, lowering, antioxidant, diuretic, nephroprotective constituents present in Melia azadirachta. These results suggest the usefulness of aqueous plant extract of Melia azadirachta as an antiurolithiatic agent.

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Section: Discussionsupporting

confidence: 80%

A Study on Antiurolithiatic Activity of Melia Azadirachta L. Aqueous Extract in Rats

Hwisa¹,

Assaleh²,

Gindi³

et al. 2014

AJPS

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“…As a result, calcium and uric acid are flushed out via the urine leaving a lesser chance of precipitation with a decreased formation as well as the growth of urinary stone. The excretion of calcium and uric acid were gradually increased in stone induced animals which is in accordance with the earlier reports [18]. Nucleation and precipitation of calcium oxalate from urine and subsequent crystal growth [19] is favoured by increase in the urinary calcium.…”

Section: Discussionsupporting

confidence: 79%

Evaluation of Antiurolithic Activity of Alcoholic Extract of Roots of Cissampelos Pareira in Albino Rats

Sayana

Khanwelkar

Nimmagadda³

et al. 2014

JCDR

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Background: In ayurvedic system of medicine a vast number of medicinal plants are reported to possess with antiurolithic activity. Aim:To study the antiurolithic activity of alcoholic extract of roots of Cissampelos pareira (AERCP) in chemicals induced urolithiasis in albino rats. Materials and Methods:Nine Groups of albino rats (n=6) were used to evaluate the antiurolithic activity of alcoholic extract of roots of C.Pareira. Group I received with rat chow diet, Group II with 2% Ammonium chloride (AC) and 0.75% Ethylene glycol (EG) Group III with EG plus AC and cystone (5 ml/kg), Groups IV, V, VI with low (100 mg/kg), medium (200 mg/kg), and high (400 mg/kg) doses of root extract, Groups VII, VIII, IX with EG plus AC and low (100 mg/kg), medium (200 mg/kg), and high (400 mg/kg) doses of root extract respectively for 10 days. Urolithiasis was induced by supplying drinking water mixed with 2% Ammonium chloride and 0.75% Ethylene glycol for 10 days. On 11 th day three rats from each Group were kept in one metabolic cage and urine (pooled) collected for 24h was subjected for estimation of biochemical parameters like urinary calcium, uric acid and magnesium. Blood was collected on the same day and analysed for various parameters. Kidneys were observed for the histopathological changes.

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“…Rats in group II showed a significant elevation in urinary phosphate was observed in. The urinary excretion growth of phosphate and oxalate seems to give an area adapted for stone formation by composing Caph crystals, which increase epitaxial CaOx retention (Karadi et al 2006;Divakar et al 2010). Treatment with N. sativa L. seeds oil restores urinary phosphate rate, thereby decreasing the risk of calculi formation.…”

Section: Discussionmentioning

confidence: 99%

“…However, oxalate and calcium excretion in urine has significantly increased. It is accepted that high level in oxalate is more markedly risk parameter in the induction of kidney stones than hypercalciuria, so levels of urinary oxalate are comparatively more important than calcium (Divakar et al 2010). Oxalate has a crucial role in calculi formation and has about 15 fold higher effect than urinary calcium (Borghi et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective and Diuretic Effect of Nigella Sativa L Seeds Oil on Lithiasic Wistar Rats

Benhelima¹,

Kaid-Omar²,

Hemida³

et al. 2016

AJTCAM

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Background and objective: The purpose of the current investigation was to study the influences, preventive and diuretic, of Nigella sativa L. seeds oil (NSSO) on calcium oxalate (CaOx) urolithiasis induced in Wistar male rats. Methodology: Seeds of Nigella sativa L. (N.S) were analysed for the evaluation of the concentration of oxalate and calcium. Nigella sativa L. seeds oil is obtained by hydrodistillation and HPTLC densitometric method was adopted to determine the amount of thymoquinone (TQ) present. Thirty male Wistar rats were divided into 5 groups (N=6). Group I, negative control, drank tap water. The other groups were II Positive control, III, IV and V received a treatment model inducing calcium oxalate urolithiasis for 28 days, using an aqueous solution involve 0.75% (EG) ethylene glycol and 1.0 % (AC) chloride ammonium. Rats in group III received in addition, 750 mg/kg Cystone from the beginning to the end of calculi induction experimentation. However, rats in Groups IV and V received (NSSO) at 5 ml/kg b.w by gavage on days 1 st to 28 th and 15 th to 28 th days, respectively. On days 0, 7, 14, 21 and 28, body weights were measured and the 24-hour urine samples were accumulated and analysed for biochemical elements. On the 28 th day, blood samples were collected for the estimation of serum parameters including creatinine, BUN and uric acid. All animals were sacrificed at the end of the experiment and the kidneys were detached for histopathological examination. Results: Administration of (NSSO) at 5 ml/kg body weight/dose/day for 28 days exerts a protective effect by reducing significantly (p <0.01) urinary and serum rates of calcium, phosphate and oxalate. This preventive diet could increase the volume of urine excreted. Conclusion:The nephroprotectrice and diuretic activity demonstrated by Nigella sativa L. gives a scientific basis that approves their traditional use like a remedy against urolithiasis.

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Protective effect of the hydro-alcoholic extract of Rubia cordifolia roots against ethylene glycol induced urolithiasis in rats

Cited by 109 publications

References 13 publications

A Study on Antiurolithiatic Activity of <i>Melia </i><i>A</i><i>zadirachta</i> L. Aqueous Extract in Rats

A Study on Antiurolithiatic Activity of <i>Melia </i><i>A</i><i>zadirachta</i> L. Aqueous Extract in Rats

Evaluation of Antiurolithic Activity of Alcoholic Extract of Roots of Cissampelos Pareira in Albino Rats

Nephroprotective and Diuretic Effect of Nigella Sativa L Seeds Oil on Lithiasic Wistar Rats

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