Protective Effect of the Pearl Extract from Pinctada fucata martensii Dunker on UV‐Induced Photoaging in Mice

Abstract

Although the effect of pearl powder has been recognized for more than a thousand years from healthcare to beauty care, there has yet to be an in‐depth understanding of its anti‐photoaging effect. In the present study, the protective effect of pearl extract (PE) on UV‐induced photoaging in mice was evaluated. First, the amino acid analysis of PE was carried out. Then, different dosages of pearl extract gel (PEG) were applied topically on the shaved dorsal skins regions of mice before UV irradiation. Skin physiological and histological analysis, antioxidant enzymes and inflammatory factor test were used to evaluate the anti‐photoaging effect of PEG. The results showed that PEG contained 14 amino acids, and could inhibit UV‐irritated skin wrinkles, laxity, thickness, and dryness. Moreover, PEG upregulated the activities of CAT, GSH‐Px, SOD and decreased MDA level, and suppressed the production of IL‐1β, IL‐6, PGE2, TNF‐α, and COX‐2 in UV‐irradiated mice. The therapeutic effect in high dose PEG group was superior to those of positive control (Vitamin E). This study demonstrated the underlying mechanisms of PEG against UV‐irritated photoaging. And PEG possesses a potential use in photoprotective medicines and cosmetics.

The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress

“…After one week of adaptation, the mice were randomly divided into the following groups: control, model (UV radiation), low dose treatment (UV radiation + 150 mg/kg purslane extract), medium dose treatment (UV radiation + 300 mg/kg purslane extract), high dose treatment (UV radiation + 600 mg/kg purslane extract), and positive treatment (UV radiation + 100 mg/kg Vitamin E); 8 mice were allocated to each group [ 32 ]. A UV-induced skin injury model was established using a UV light box.…”

Marine Bioactive Peptides: Anti-Photoaging Mechanisms and Potential Skin Protective Effects

“…Specifically, DPFRHY demonstrated notable anti-inflammatory and cell repair properties [39]. Furthermore, PEG exhibited the inhibition of IL-1β, IL-6, PGE, TNF-α, and COX-2 production while also providing enhanced protection against UV-induced photoaging in mice [40]. The polypeptide (SEP) extracted from by-products of bonito fish can significantly reduce the expression levels of IL-6, IL-10, and TNF-α and has a good anti-inflammatory effect [72].…”

“…Research has demonstrated that marine bioactive peptides play a significant role in numerous anti-photoaging hypotheses [20], encompassing the oxidative stress theory [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], the inflammatory response theory [38][39][40], the matrix metalloproteinase abnormal expression theory [41][42][43][44][45], the hyaluronidase abnormal expression theory [46][47][48][49][50], the elastase abnormal expression theory [47,51,52], and the melanin over-synthesis theory [53][54][55][56][57] (Figure 1). Based on this premise, the present study critically examines the anti-photo-aging properties of marine bioactive peptides, encompassing their molecular characterization and underlying mechanisms associated with photoaging.…”