Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice

Wang, Yongqiang; Cai, Li; Zhang, Nan; Zhang, Jing; Wang, Haihong; Zhu, Wei

doi:10.1186/s12906-020-02911-w

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…In an in vivo experiment, the administration of total flavonoids from Ixeris sonchifolia (Bae.) Hance to mice with HSK significantly improved corneal lesions, reduced infection, and increased survival rates, underscoring its therapeutic potential [75].…”

Section: Blocking Hsv-1 Infection Via Flavonoidsmentioning

confidence: 84%

Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle

Šudomová,

Hassan

2023

Viruses

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The herpes simplex virus (HSV) is a double-stranded DNA human virus that causes persistent infections with recurrent outbreaks. HSV exists in two forms: HSV-1, responsible for oral herpes, and HSV-2, primarily causing genital herpes. Both types can lead to significant complications, including neurological issues. Conventional treatment, involving acyclovir and its derivatives, faces challenges due to drug resistance. This underscores the imperative for continual research and development of new drugs, with a particular emphasis on exploring the potential of natural antivirals. Flavonoids have demonstrated promise in combating various viruses, including those within the herpesvirus family. This review, delving into recent studies, reveals the intricate mechanisms by which flavonoids decode their antiviral capabilities against HSV. By disrupting key stages of the viral life cycle, such as attachment to host cells, entry, DNA replication, latency, and reactivation, flavonoids emerge as formidable contenders in the ongoing battle against HSV infections.

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Section: Blocking Hsv-1 Infection Via Flavonoidsmentioning

confidence: 84%

Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle

Šudomová,

Hassan

2023

Viruses

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“… 2020 ; Wang, Cai, et al. 2020 ). Flavonoids have been studied against a variety of DNA and RNA viruses.…”

Section: Antiviral Constituents In Traditional Chinese Medicinesmentioning

confidence: 99%

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

Chen

2022

Pharmaceutical Biology

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Context Viruses have the characteristics of rapid transmission and high mortality. At present, western medicines still lack an ideal antiviral. As natural products, many traditional Chinese medicines (TCM) have certain inhibitory effects on viruses, which has become the hotspot of medical research in recent years. Objective The antiviral active ingredients and mechanisms of TCM against viral diseases was studied in combination with the pathogenesis of viral diseases and antiviral effects. Materials and methods English and Chinese literature from 1999 to 2021 was collected from databases including Web of Science, PubMed, Elsevier, Chinese Pharmacopoeia 2020 (CP), and CNKI (Chinese). Traditional Chinese medicines (TCM), active ingredients, antiviral, mechanism of action, and anti-inflammatory effect were used as the key words. Results The antiviral activity of TCM is clarified to put forward a strategy for discovering active compounds against viruses, and provide reference for screening antivirus drugs from TCM. TCM can not only directly kill viruses and inhibit the proliferation of viruses in cells, but also prevent viruses from infecting cells and causing cytophilia. It can also regulate the human immune system, enhance human immunity, and play an indirect antiviral role. Discussion and conclusion Based on the experimental study and antiviral mechanism of TCM, this paper can provide analytical evidence that supports the effectiveness of TCM in treating virus infections, as well as their mechanisms against viruses. It could be helpful to provide reference for the research and development of innovative TCMs with multiple components, multiple targets and low toxicity.

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“…Hance (ISH) on herpes simplex keratitis (HSK) in mice was evaluated. The study outcome specified that treatment with ISH total flavonoids substantially improved the corneal lesion degree and increased mice survival rate [ 101 ]. The replication of VZV was considerably impeded by quercetin and isoquercitrin, and both flavonoid compounds were analytically detected in Elaeocarpus sylvestris .…”

Section: Flavonoids Target Human Herpesviruses Of the Nervous Systemmentioning

confidence: 99%

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

Šudomová¹,

Berchová‐Bímová

Mazuráková

et al. 2022

Viruses

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Human herpesviruses (HHVs) are large DNA viruses with highly infectious characteristics. HHVs can induce lytic and latent infections in their host, and most of these viruses are neurotropic, with the capacity to generate severe and chronic neurological diseases of the peripheral nervous system (PNS) and central nervous system (CNS). Treatment of HHV infections based on strategies that include natural products-derived drugs is one of the most rapidly developing fields of modern medicine. Therefore, in this paper, we lend insights into the recent advances that have been achieved during the past five years in utilizing flavonoids as promising natural drugs for the treatment of HHVs infections of the nervous system such as alpha-herpesviruses (herpes simplex virus type 1, type 2, and varicella-zoster virus), beta-herpesviruses (human cytomegalovirus), and gamma-herpesviruses (Epstein–Barr virus and Kaposi sarcoma-associated herpesvirus). The neurological complications associated with infections induced by the reviewed herpesviruses are emphasized. Additionally, this work covers all possible mechanisms and pathways by which flavonoids induce promising therapeutic actions against the above-mentioned herpesviruses.

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Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice

Cited by 9 publications

References 39 publications

Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle

Flavonoids with Anti-Herpes Simplex Virus Properties: Deciphering Their Mechanisms in Disrupting the Viral Life Cycle

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights

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