Protective effect of triterpenoid fractions from the rhizomes of Astilbe chinensis on cyclophosphamide-induced toxicity in tumor-bearing mice

Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran

“…Peripheral WBC count and bone-marrow cellularity are two frequently studied clinical parameters that accurately reflect chemotherapeutic injury [19]. In the present study, treatment with arabinoxylans could increase peripheral WBC count and bonemarrow cellularity in S180 tumor-bearing mice, which indicates that arabinoxylans can stimulate the hemopoietic system and stem cell proliferation.…”

Immuno-enhancement effects of Shenqi Fuzheng Injection on cyclophosphamide-induced immunosuppression in Balb/c mice

“…Cy itself is inactive and must first undergo metabolic activation, catalyzed by the hepatic cytochrome P450 to 4-hydroxy-cyclophosphamide and later to phosphoramide mustard and acrolein. The mustard component produces a cytotoxic effect by preventing cell replication, while acrolein is linked with its toxic side effects (Sun and Peng, 2008). Toxicities of Cy include the suppression of white blood cells, nausea, vomiting, gonadal atrophy, liver, renal, and bladder injury.…”

In-vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L. seed oil

“…Cyclophosphamide itself is inactive and must first undergo metabolic activation, catalyzed by the hepatic cytochrome P450 to 4-hydroxy-cyclophosphamide and later to phosphoramide mustard and acrolein. The mustard component produces a cytotoxic effect by preventing cell replication, while acrolein is linked with its toxic side effects [43]. Toxicities of cyclophosphamide include the suppression of white blood cells, nausea, vomiting, gonadal atrophy, liver, renal, and bladder injury.…”