Protective Effect of Vaccination Against Induced Influenza A.

Protective Effect of Vaccination Against Induced Influenza B.

“…Thus, the effect of the initial inoculation persisted for an interval of 4 months and vaccination at this time exerted little or no effect upon the serological titer. These observations conform with those described in the previous study (1 In the present experiment with a preparation of influenza virus Type B, there were many more instances in which clinical reactions occurred in the absence of serological reactions, both in control and vaccinated subjects. Of the 12 subjects in the control group who had temperatures of 1000 or more, 7 had no demonstrable increase in antibody titer; while of the 9 subjects in the vaccinated group who had this degree of fever, It is of interest to compare the results of the present study with those reported earlier (6) which were concerned with the response to a second exposure of individuals previously infected with influenza virus, Type B.…”

“…The vaccine employed was the same as that used in the preceding study (1) and contained influenza virus of both Types A and B. The immunizing capacity of the vaccine for mice was such that 2 doses of 0.5 ml.…”

Protective Effect of Vaccination Against Induced Influenza a 1

“…A preliminary report of the clinical results has already been made (2). The present report is intended to present the details of the evidence for the protective effect of vaccination against induced influenza A, including the laboratory investigations which constituted an important phase of the study.…”

Role of U.S. military research programs in the development of U.S.-licensed vaccines for naturally occurring infectious diseases

“…Francis is credited with having been the first scientist to isolate influenza virus from a human in the United States in 1935 and also the first to isolate influenza B. The influenza virus strains contributed by Dr. Francis were used to make an inactivated whole-virus vaccine evaluated by clinical studies in hospitalized inmates, military recruits, and college students [6][7][8]. U.S. Army troops were vaccinated against influenza type A starting in 1943 prior to influenza vaccine licensure by Parke, Davis and Company of Detroit, Michigan in 1945 because of concern that mobilization of troops could enhance influenza transmission resulting in another serious pandemic.…”