Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry

Richard, Tristan; Poupard, Pascal; Nassra, Merian; Papastamoulis, Yorgos; Iglésias, Marie-Laure; Krisa, Stéphanie; Waffo-Téguo, Pierre; Mérillon, Jean‐Michel; Monti, Jean‐Pierre

doi:10.1016/j.bmc.2011.04.001

Cited by 73 publications

(59 citation statements)

References 27 publications

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“…There are extensive investigations which have been made to establish the neuroprotectiverole of polyphenols in vitro and in vivo tests. As previously reported by Richard et al (2011), a submicromolar concentration of Aβ peptide was sufficient to elicit metabolic interruptions in PC12 cells. Both Frankenia species have efficient protective effect against cell death induced by Aβ peptide.…”

Section: Discussionsupporting

confidence: 80%

“…Flavonoids such as proanthocyanidins found in different berries and cocoa that are derived from flavon-3-ols such as catechin or epicatechin, found in parsley or chamomile and other phenolic compounds, but also natural products from different chemical classes such a terpenoids, have been shown to exert anti-inflammatory effects in different pathological conditions (Tili and Michaille, 2016). Indeed, Zeng et al (2011) showed that quercetin-galactoside (hyperoside) which is present in the methanolic extract of G. flavum significantly inhibited Aβ 25-35 -induced cytotoxicity and apoptosis by reversing Aβ-induced mitochondrial dysfunction, including mitochondrial membrane potential decrease, reactive oxygen species production, and mitochondrial release of cytochrome c. Recently, numerous studies have suggested that a wide range of polyphenols may have neuroprotective effects both in vitro and in vivo by exerting protective effects through their ability to scavenge ROS or by directly inhibiting the formation of Aβ fibril deposits in the brain (Richard et al 2011). F. thymifolia was shown to contain high amount of phenolic acids (caffeic, chlorogenic, sinapic and gallic acids).…”

Section: Discussionmentioning

confidence: 99%

“…The great antioxidant activities of methanolic extracts and their phenolic composition can explain their highest capacities to inhibit Aβ aggregation. Thus it might be reasonable to consider that phenolic compounds might prevent neurodegenerative diseases, not only by scavenging reactive oxygen species but also by directly inhibiting the aggregation of Aβ fibrils in the brain by complex formation (Richard et al 2011). Furthermore, the toxicity of S. sodomaeum against PC12 cells viability was may be due to the presence of alkaloids.…”

Section: Discussionmentioning

confidence: 99%

“…All plant extracts, except S.sodomaeum, did not significantly affect cells viabilityat concentration up to 400 µM ( Figure 2a).Indeed, incubation of PC12 cells with 5 µM Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) , for 24 h decreased the cell viability compared to control to 44% (Figure 2b). In order to evaluate the protective effect of extracts, Aβ was added to PC12 cells simultaneously to the extracts (100, 200 and 400 µg/ml).…”

Section: Neuroprotective Activity Of Methanolic Extractsmentioning

confidence: 94%

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Potential Antioxidant Capacities and Neuroprotective Properties of Six Tunisian Medicinal Species

2017

International Journal of Medicinal Plants and Natural Products

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Neuroprotective Activity Of Methanolic Extractsmentioning

confidence: 94%

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Potential Antioxidant Capacities and Neuroprotective Properties of Six Tunisian Medicinal Species

2017

International Journal of Medicinal Plants and Natural Products

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“…In a study by Riviere et al, viniferin glycoside, which was extracted from stem of V. vinifera, exhibited the strongest inhibitory activity of Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) aggregation in vitro. Also, viniferin glycoside inhibited Aβ cytotoxicity and the non-covalent complex between viniferin glycoside and Aβ (Rivière et al, 2010;Richard et al, 2011).…”

Section: Vitis Viniferamentioning

confidence: 99%

Medicinal herbs in Iranian traditional medicine for learning and memory

Shojaii¹,

Ghods²,

Fard³

2016

Afr. J. Trad. Compl. Alt. Med.

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Background: There are some factors such as age, stress and emotions that may lead to impaired learning, memory loss, amnesia, and dementia or threats like Schizophrenia and Alzheimer's disease (AD). Traditional Iranian medicine (TIM) recommended some herbs and herbal preparations for treatment or prevention of CNS problems. In this study, the scientific evidences related to effectiveness of TIM herbal medicine on memory and learning will be reviewed. Materials and Methods:The scientific evidences of the plant efficacy were searched in electronic databases including Pub Med, Scopus, SID, Science Direct, and Google Scholar by keywords like memory, Alzheimer, amnesia, learning and scientific plant names from 1969 to 2014. Results: The finding of this study confirmed effectiveness of some of TIM medicinal plants on enhancing memory and learning or in treatment or prevention of amnesia and AD. Some of TIM plants like Melissa officinalis, Crocus sativus and Nigella sativa showed improving effect on memory in clinical trials. In some cases, the active principles responsible for efficacy of these plants on memory were also determined. Conclusion: Most of the studies on TIM plants were designed in animal models and a few herbs were evaluated in clinical trials on AD. Also, for some of the herbal medicine used in TIM, there are no or not enough studies to confirm their effectiveness on memory and learning. Therefore, further experimental and clinical studies are necessary to evaluate the effectiveness of these plants on memory and AD and also to determine the active components of them.

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Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer’s Amyloid β‐Peptide Aggregation

et al. 2015

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The screening of natural products in the search for new lead compounds against Alzheimers disease has unveiled several plant polyphenols that are capable of inhibiting the formation of toxic b-amyloid fibrils.G allic acid based gallotannins are among these polyphenols,but their antifibrillogenic activity has thus far been examined using "tannic acid", ac ommercial mixture of gallotannins and other galloylated glucopyranoses.T he first total syntheses of two true gallotannins,ahexagalloylglucopyranose and ad ecagalloylated compound whose structure is commonly used to depict "tannic acid", are nowd escribed. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid b-peptide (Ab)a ggregation in vitro,a nd monogalloylated a-glucogallin and an atural b-hexagalloylglucose are shown to be the strongest inhibitors.Abnormal amyloid b-peptide (Ab)accumulation and aggregation into toxic fibrils is one of the major processes occurring during the progression of Alzheimers disease (AD), which today affects approximately 36 million people worldwide. [1a, 2] Although the etiology of this severe neurodegenerative disorder,w hich causes dementia in the elderly,r emains unknown, [1b,2] ag lobal effort was initiated in the early 1990s to search for neuroprotective therapeutic agents with antifibrillogenic activity. [1c,d] In this context, natural-product screening programs were implemented with the aim of identifying molecules that are capable of preventing the aggregation and/or promoting the clearance of Ab. [1c,e] Afew recent investigations have focused on plant polyphenols, which are known for their antioxidant activity and their metal-chelation and protein-binding abilities,aset of properties that makes them potentially good candidates as multifunctional drugs for the treatment of AD and other fibrillogenic neurodegenerative disorders,s uch as Parkinsons and Huntingtons diseases. [1c,e,3] Curcuminoids,s uch as curcumin itself,stilbenoids,s uch as resveratrol, and flavonoids,s uch as myricetin and epigallocatechin gallate (EGCg), all belong to aselect group of plant polyphenols that have been identified as inhibitors of Ab aggregation, mainly in vitro. [1c, 4] Gallic acid based polyphenols,s uch as the gallotannins and ellagitannins (Scheme 1), [3a, 5, 6a,b] have surprisingly been mostly left aside in these investigations,likely because of the difficulties associated with accessing them in pure form.Concerning the gallotannins,tothe best of our knowledge, investigations have been limited to the evaluation of 1) their ultimate precursor,1 ,2,3,4,6-penta-O-galloyl-b-d-glucopyranose (b-PGG, b-3;Scheme 1), which was shown to inhibit Ab fibril formation and to destabilize pre-formed Ab fibrils in vitro and in vivo, [7a] and 2) commercial tannic acid (TA), which was reported to destabilize Ab fibrils in vitro. [7b] TA is the sole available standard that is commonly but inappropriately used to assess the (biological) properties of gallotannins. [8,9a] It is usually depicted as the meta-deps...

show abstract

Protective effect of ε-viniferin on β-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry

Cited by 73 publications

References 27 publications

Potential Antioxidant Capacities and Neuroprotective Properties of Six Tunisian Medicinal Species

Potential Antioxidant Capacities and Neuroprotective Properties of Six Tunisian Medicinal Species

Medicinal herbs in Iranian traditional medicine for learning and memory

Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer’s Amyloid β‐Peptide Aggregation

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